A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis

NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy

(2022) Yoshihiro Otani et al.   CLINICAL CANCER RESEARCH

Harnessing cytokines and chemokines for cancer therapy

(2022) David J. Propper et al.   Nature Reviews Clinical Oncology

A pyroptosis nanotuner for cancer therapy

(2022) Binlong Chen et al.   Nature Nanotechnology

Fueling the Fire: Inflammatory Forms of Cell Death and Implications for Cancer Immunotherapy

(2021) Sheera R. Rosenbaum et al.   Cancer Discovery

Advancing oncolytic virus therapy by understanding the biology

(2021) Howard L. Kaufman et al.   Nature Reviews Clinical Oncology

Channelling inflammation: gasdermins in physiology and disease

(2021) Xing Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells

(2021) Haein An et al.   Cell Death & Disease

Beyond Photo: Xdynamic Therapies in Fighting Cancer

(2021) Sheng Wang et al.   ADVANCED MATERIALS

MDSC: Markers, development, states, and unaddressed complexity

(2021) Samarth Hegde et al.   IMMUNITY

Oncolytic virotherapy: Potentially a game-changing tumor treatment

(2021) Tobias Kessler et al.   CANCER CELL

Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment

(2021) Yu Yang et al.   ADVANCED DRUG DELIVERY REVIEWS

Engineering Multienzyme‐Mimicking Covalent Organic Frameworks as Pyroptosis Inducers for Boosting Antitumor Immunity

(2021) Liang Zhang et al.   ADVANCED MATERIALS

Tumor‐Microenvironment‐Activatable Polymer Nano‐Immunomodulator for Precision Cancer Photoimmunotherapy

(2021) Jing Liu et al.   ADVANCED MATERIALS

Precise Subcellular Organelle Targeting for Boosting Endogenous‐Stimuli‐Mediated Tumor Therapy

(2021) Wenyao Zhen et al.   ADVANCED MATERIALS

Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB–IVM1a melanoma: a randomized, open-label, phase 2 trial

(2021) R. Dummer et al.   NATURE MEDICINE

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

(2021) Lukas Kraehenbuehl et al.   Nature Reviews Clinical Oncology

Oncolytic virotherapy as immunotherapy

(2021) Alan Melcher et al.   SCIENCE

Myeloid-Derived Suppressor Cells: A Propitious Road to Clinic

(2021) Amit Grover et al.   Cancer Discovery

Engineering Stimuli‐Activatable Boolean Logic Prodrug Nanoparticles for Combination Cancer Immunotherapy

(2020) Bo Hou et al.   ADVANCED MATERIALS

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Tissue-resident memory T cells in breast cancer control and immunotherapy responses

(2020) Ann Byrne et al.   Nature Reviews Clinical Oncology

Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges

(2020) John D. Martin et al.   Nature Reviews Clinical Oncology

Embelin Promotes Oncolytic Vaccinia Virus-Mediated Antitumor Immunity Through Disruption of IL-6/STAT3 Signaling in Lymphoma

(2020) Peng Wang et al.   OncoTargets and Therapy

Directing Traffic: How to Effectively Drive T Cells into Tumors

(2020) Annabelle J. Anandappa et al.   Cancer Discovery

Objective Response Rate Among Patients With Locally Advanced or Metastatic Sarcoma Treated With Talimogene Laherparepvec in Combination With Pembrolizumab

(2020) Ciara M. Kelly et al.   JAMA Oncology

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

(2020) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

(2020) Ayon Ibrahim et al.   Cell Metabolism

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

(2020) Xiaona Sun et al.   Nature Communications

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma

(2019) Gang Meng et al.   Molecular Therapy-Oncolytics

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

(2019) Wei Tao et al.   ACS Nano

Optimizing oncolytic virotherapy in cancer treatment

(2019) Kevin Harrington et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups

(2019) Lawrence P. Andrews et al.   NATURE IMMUNOLOGY

Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

(2019) Gang Meng et al.   BRITISH JOURNAL OF CANCER

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

(2019) Zhiyong Wang et al.   Nature Communications

The function and dysfunction of memory CD8+ T cells in tumor immunity

(2018) James L. Reading et al.   IMMUNOLOGICAL REVIEWS

Tissue-resident memory T cells at the center of immunity to solid tumors

(2018) Derk Amsen et al.   NATURE IMMUNOLOGY

Targeting the IL-6/JAK/STAT3 signalling axis in cancer

(2018) Daniel E. Johnson et al.   Nature Reviews Clinical Oncology

Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide

(2018) Lu Lu et al.   ONCOGENE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

A Paradigm Shift in Cancer Immunotherapy: From Enhancement to Normalization

(2018) Miguel F. Sanmamed et al.   CELL

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Inhibition of LEF1-Mediated DCLK1 by Niclosamide Attenuates Colorectal Cancer Stemness

(2018) So-Yeon Park et al.   CLINICAL CANCER RESEARCH

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

Inflammation-Triggered Cancer Immunotherapy by Programmed Delivery of CpG and Anti-PD1 Antibody

(2016) Chao Wang et al.   ADVANCED MATERIALS

Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells

(2016) A Takasu et al.   CANCER GENE THERAPY

Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy

(2016) Chao Liang et al.   CHEMICAL SOCIETY REVIEWS

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Synthetic Nanoparticles for Vaccines and Immunotherapy

(2015) Darrell J. Irvine et al.   CHEMICAL REVIEWS

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

Newly Recruited CD11b+, GR-1+, Ly6ChighMyeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus

(2015) Derek R. Clements et al.   JOURNAL OF IMMUNOLOGY

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

The therapeutic effect of death: Newcastle disease virus and its antitumor potential

(2015) Sara Cuadrado-Castano et al.   VIRUS RESEARCH

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

Multi-targeted therapy of cancer by niclosamide: A new application for an old drug

(2014) Yonghe Li et al.   CANCER LETTERS

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

(2014) Roy S. Herbst et al.   NATURE

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

(2013) H Inoue et al.   CELL DEATH AND DIFFERENTIATION

The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo

(2012) Shuo Gu et al.   CELL

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Redeployment-based drug screening identifies the anti-helminthic niclosamide as anti-myeloma therapy that also reduces free light chain production

(2011) F L Khanim et al.   Blood Cancer Journal

PI3K and STAT3: A New Alliance

(2011) P. K. Vogt et al.   Cancer Discovery

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

The HSV-2 mutant ΔPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins

(2009) A G Colunga et al.   GENE THERAPY

Diversity in T Cell Memory: An Embarrassment of Riches

(2009) Stephen C. Jameson et al.   IMMUNITY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE