Acute cadmium exposure induces GSDME-mediated pyroptosis in triple-negative breast cancer cells through ROS generation and NLRP3 inflammasome pathway activation

Mechanism and regulation of pyroptosis-mediated in cancer cell death

(2020) Jianwei Ruan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

(2020) Zhongyuan Liu et al.   Journal of Neuroinflammation

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver

(2020) Heng Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of vdac2 inhibits spermatogenesis via JNK and P53 signalling in mice exposed to cadmium

(2020) Yu Fang et al.   TOXICOLOGY LETTERS

Cadmium exposure and risk of breast cancer: A dose-response meta-analysis of cohort studies

(2020) Tommaso Filippini et al.   ENVIRONMENT INTERNATIONAL

Cadmium chloride-induced transgenerational neurotoxicity in zebrafish development

(2020) Jingjing Tian et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells

(2020) Caiying Zhang et al.   ENVIRONMENTAL POLLUTION

Mechanisms of Cd and Cu induced toxicity in human gastric epithelial cells: Oxidative stress, cell cycle arrest and apoptosis

(2020) Kun Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells

(2019) Xin Chou et al.   ARCHIVES OF TOXICOLOGY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Inhibition of Caspase-1-dependent pyroptosis attenuates copper-induced apoptosis in chicken hepatocytes

(2019) Jianzhao Liao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells

(2019) Yang Long et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells

(2019) Lucero Paniagua et al.   REPRODUCTIVE TOXICOLOGY

Roles of three Es-Caspases during spermatogenesis and Cadmium-induced apoptosis in Eriocheir sinensis

(2018) Ya-Ru Xu et al.   Aging-US

Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells

(2018) Zhongguo Shan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes

(2018) Dusadee Ospondpant et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

MAPK/JNK1 activation protects cells against cadmium-induced autophagic cell death via differential regulation of catalase and heme oxygenase-1 in oral cancer cells

(2017) Keum-Young So et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cadmium stimulates metastasis-associated phenotype in triple-negative breast cancer cells through integrin and β-catenin signaling

(2017) Zhengxi Wei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells

(2016) Kuan-Chun Huang et al.   EUROPEAN JOURNAL OF CANCER

Extracellular histones reduce survival and angiogenic responses of late outgrowth progenitor and mature endothelial cells

(2016) H. A. Mena et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?

(2016) Tarique Hussain et al.   Oxidative Medicine and Cellular Longevity

Urinary Cadmium Concentration and Risk of Breast Cancer: A Systematic Review and Dose-Response Meta-Analysis

(2015) Susanna C. Larsson et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Modulation of cytokines and chemokines expression by NAC in cadmium chloride treated human lung cells

(2015) Caroline O. Odewumi et al.   ENVIRONMENTAL TOXICOLOGY

Reactive oxygen species at the crossroads of inflammasome and inflammation

(2014) Anantha Harijith et al.   Frontiers in Physiology

Cadmium Modifies the Cell Cycle and Apoptotic Profiles of Human Breast Cancer Cells Treated with 5-Fluorouracil

(2013) Yolande Asara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Multiple roles of cadmium in cell death and survival

(2010) Douglas M. Templeton et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Involvement of E2F1 transcriptional activity in cadmium-induced cell-cycle arrest at G1 in human lung fibroblasts

(2010) You-Jin Choi et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Cadmium-induced induction of cell death in human lens epithelial cells: Implications to smoking associated cataractogenesis

(2010) Nilesh M. Kalariya et al.   TOXICOLOGY LETTERS