Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies

Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections

(2021) Pablo Juanes-Velasco et al.   Frontiers in Cellular and Infection Microbiology

Beyond the concept of cold and hot tumors for the development of novel predictive biomarkers and the rational design of immunotherapy combination

(2020) Eleonore De Guillebon et al.   INTERNATIONAL JOURNAL OF CANCER

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

(2020) Isaure Vanmeerbeek et al.   OncoImmunology

Antitumour Anthracyclines: Progress and Perspectives

(2020) Maristela B. Martins‐Teixeira et al.   ChemMedChem

Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4/IKK2/SNARE-dependent exocytosis

(2020) Tat San Lau et al.   Cancer Immunology Research

HMGB1 in Radiotherapy: A Two Headed Signal Regulating Tumor Radiosensitivity and Immunity

(2020) Yin Liao et al.   OncoTargets and Therapy

Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression

(2020) Changlin Li et al.   CELLULAR ONCOLOGY

Nanomedicine and Onco-Immunotherapy: From the Bench to Bedside to Biomarkers

(2020) Vanessa Acebes-Fernández et al.   Nanomaterials

Mechanisms of immune escape in the cancer immune cycle

(2020) Sha Tang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy

(2020) Hanzhang Zhu et al.   CELLULAR ONCOLOGY

Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials

(2020) Lourdes Hontecillas-Prieto et al.   Frontiers in Genetics

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

(2020) Tania Løve Aaes et al.   CELL DEATH AND DIFFERENTIATION

Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy

(2019) Bernardo Rapoport et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Natural compound inducers of immunogenic cell death

(2019) Marc Diederich   ARCHIVES OF PHARMACAL RESEARCH

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Phase I/Ib Study of Pembrolizumab Plus Vorinostat in Advanced/Metastatic Non–Small Cell Lung Cancer

(2019) Jhanelle E. Gray et al.   CLINICAL CANCER RESEARCH

Cisplatin and oxaliplatin induce similar immunogenic changes in preclinical models of head and neck cancer

(2019) So-Jin Park et al.   ORAL ONCOLOGY

Extracorporeal photochemotherapy induces bona fide immunogenic cell death

(2019) Kazuki Tatsuno et al.   Cell Death & Disease

Calreticulin is a Critical Cell Survival Factor in Malignant Neoplasms

(2019) Arum Han et al.   PLOS BIOLOGY

Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination

(2019) Bastien Doix et al.   Frontiers in Oncology

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients

(2019) Iva Truxova et al.   HAEMATOLOGICA

The Human Immunopeptidome Project: a roadmap to predict and treat immune diseases

(2019) Juan Antonio Vizcaíno et al.   MOLECULAR & CELLULAR PROTEOMICS

Calreticulin exposure correlates with robust adaptive antitumor immunity and favorable prognosis in ovarian carcinoma patients

(2019) Lenka Kasikova et al.   Journal for ImmunoTherapy of Cancer

Comparison of the effects of photon, proton and carbon-ion radiation on the ecto-calreticulin exposure in various tumor cell lines

(2019) Yangle Huang et al.   Annals of Translational Medicine

Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

(2019) Claire Donohoe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

eIF2α phosphorylation is pathognomonic for immunogenic cell death

(2018) Lucillia Bezu et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Intraperitoneal oxaliplatin administration inhibits the tumor immunosuppressive microenvironment in an abdominal implantation model of colon cancer

(2018) Hong‑Feng Gou et al.   Molecular Medicine Reports

Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab

(2018) Xuzhi He et al.   Oncotarget

DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells

(2018) Johannes Laengle et al.   Theranostics

PKR and GCN2 stress kinases promote an ER stress-independent eIF2α phosphorylation responsible for calreticulin exposure in melanoma cells

(2018) Paola Giglio et al.   OncoImmunology

Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus

(2018) Nicola E. Annels et al.   Molecular Therapy-Oncolytics

Oxaliplatin disrupts pathological features of glioma cells and associated macrophages independent of apoptosis induction

(2018) Nathan B. Roberts et al.   JOURNAL OF NEURO-ONCOLOGY

Systemic autophagy in the therapeutic response to anthracycline-based chemotherapy

(2018) Francesca Castoldi et al.   OncoImmunology

High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair

(2017) Marco E. Bianchi et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases

(2017) Benjamin Frey et al.   IMMUNOLOGICAL REVIEWS

Decoding the anticancer activity of VO-clioquinol compound: the mechanism of action and cell death pathways in human osteosarcoma cells

(2017) Ignacio E. León et al.   Metallomics

Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes

(2017) Bernd Heinrich et al.   OncoTargets and Therapy

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Redox-Dependent HMGB1 Isoforms as Pivotal Co-Ordinators of Drug-Induced Liver Injury: Mechanistic Biomarkers and Therapeutic Targets

(2016) Jonathan D. Lea et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunogenic cell death by oncolytic herpes simplex virus type 1 in squamous cell carcinoma cells

(2016) A Takasu et al.   CANCER GENE THERAPY

Calreticulin Expression in Human Non–Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis

(2016) Jitka Fucikova et al.   CANCER RESEARCH

Deciphering the effect of an oxovanadium(iv) complex with the flavonoid chrysin (VOChrys) on intracellular cell signalling pathways in an osteosarcoma cell line

(2016) Ignacio E. León et al.   Metallomics

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

(2016) Chiara Pozzi et al.   NATURE MEDICINE

AAgAtlas 1.0: a human autoantigen database

(2016) Dan Wang et al.   NUCLEIC ACIDS RESEARCH

Damage-associated molecular patterns in cancer: a double-edged sword

(2016) C Hernandez et al.   ONCOGENE

Extracellular purines, purinergic receptors and tumor growth

(2016) F Di Virgilio et al.   ONCOGENE

Effects of active bufadienolide compounds on human cancer cells and CD4+CD25+Foxp3+ regulatory T cells in mitogen-activated human peripheral blood mononuclear cells

(2016) Bo Yuan et al.   ONCOLOGY REPORTS

Bortezomib augments lymphocyte stimulatory cytokine signaling in the tumor microenvironment to sustain CD8+T cell antitumor function

(2016) Samuel T. Pellom et al.   Oncotarget

Prognostic value of HMGB1 in early breast cancer patients under neoadjuvant chemotherapy

(2016) Ruth Exner et al.   Cancer Medicine

Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts

(2015) Joshua C Doloff et al.   BMC CANCER

Shikonin-enhanced cell immunogenicity of tumor vaccine is mediated by the differential effects of DAMP components

(2015) Tien-Jen Lin et al.   Molecular Cancer

Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance

(2015) E. Martinez-Balibrea et al.   MOLECULAR CANCER THERAPEUTICS

Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

(2015) E. Vacchelli et al.   SCIENCE

Immunohistochemical detection of high-mobility group box 1 correlates with resistance of preoperative chemoradiotherapy for lower rectal cancer: a retrospective study

(2015) Kumiko Hongo et al.   World Journal of Surgical Oncology

Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy

(2015) Yuhao Cheng et al.   Nature Communications

Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy

(2015) Kelly Kersten et al.   Frontiers in Immunology

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

Immunogenic cell death-related biomarkers: Impact on the survival of breast cancer patients after adjuvant chemotherapy

(2015) Sylvain Ladoire et al.   OncoImmunology

Trial Watch: Immunogenic cell death inducers for anticancer chemotherapy

(2015) Jonathan Pol et al.   OncoImmunology

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

(2015) Sofia R. Gameiro et al.   Oncotarget

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Doxorubicin treatment induces tumor cell death followed by immunomodulation in a murine neuroblastoma model

(2014) SEIICHIRO INOUE et al.   Experimental and Therapeutic Medicine

Screening of novel immunogenic cell death inducers within the NCI Mechanistic Diversity Set

(2014) Abdul Qader Sukkurwala et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Autophagy-dependent ATP release from dying cells via lysosomal exocytosis

(2013) Yidan Wang et al.   Autophagy

An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors

(2013) A. C. West et al.   CANCER RESEARCH

Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8

(2013) A Q Sukkurwala et al.   CELL DEATH AND DIFFERENTIATION

Inducers of immunogenic cancer cell death

(2013) Aleksandra M. Dudek et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preclinical modeling of EGFR-specific antibody resistance: oncogenic and immune-associated escape mechanisms

(2013) G Garrido et al.   ONCOGENE

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trial watch

(2013) Laurie Menger et al.   OncoImmunology

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

The Tumor Microenvironment: Characterization, Redox Considerations, and Novel Approaches for Reactive Oxygen Species-Targeted Gene Therapy

(2012) Lucia Laura Policastro et al.   ANTIOXIDANTS & REDOX SIGNALING

Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine

(2012) Hui-Ming Chen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The future of antibodies as cancer drugs

(2012) Janice M. Reichert et al.   DRUG DISCOVERY TODAY

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

Immunogenic cell death biomarkers HMGB1, RAGE, and DNAse indicate response to radioembolization therapy and prognosis in colorectal cancer patients

(2012) Yvonne Nadine Fahmueller et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer immunoediting by the innate immune system in the absence of adaptive immunity

(2012) Timothy O’Sullivan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Mechanism of the Antitumor Effects Generated by Bortezomib

(2012) C.-L. Chang et al.   JOURNAL OF IMMUNOLOGY

Unknown

(2012) Hulda Hreggvidsdottir et al.   MOLECULAR MEDICINE

A basic study on Hypericin-PDT in vitro

(2012) Nobue Nakajima et al.   Photodiagnosis and Photodynamic Therapy

An Immunosurveillance Mechanism Controls Cancer Cell Ploidy

(2012) L. Senovilla et al.   SCIENCE

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy

(2012) Oliver J. Stoetzer et al.   TUMOR BIOLOGY

Human Tumor Cells Killed by Anthracyclines Induce a Tumor-Specific Immune Response

(2011) J. Fucikova et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation

(2011) José Augusto Nogueira-Machado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Contribution of IL-17–producing γδ T cells to the efficacy of anticancer chemotherapy

(2011) Yuting Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody

(2011) Greta Garrido et al.   JOURNAL OF IMMUNOLOGY

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2

(2011) J Chen et al.   ONCOGENE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Histone deacetylases as regulators of inflammation and immunity

(2011) Melanie R. Shakespear et al.   TRENDS IN IMMUNOLOGY

Shikonin Induces Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase Pathway in Osteosarcoma Cells

(2010) I-Chang Chang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro

(2010) Jürgen Sonnemann et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

(2010) G. Schiavoni et al.   CANCER RESEARCH

Chemotherapy induces ATP release from tumor cells

(2010) Isabelle Martins et al.   CELL CYCLE

Paclitaxel enhances early dendritic cell maturation and function through TLR4 signaling in mice

(2010) Lukas W. Pfannenstiel et al.   CELLULAR IMMUNOLOGY

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1

(2010) B Huang et al.   GENE THERAPY

A Mechanism of Release of Calreticulin from Cells During Apoptosis

(2010) Joanna M. Tarr et al.   JOURNAL OF MOLECULAR BIOLOGY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Metronomic chemotherapy: new rationale for new directions

(2010) Eddy Pasquier et al.   Nature Reviews Clinical Oncology

Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer

(2010) C K Ingemarsdotter et al.   ONCOGENE

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

(2010) Satoko Matsumura et al.   RADIATION RESEARCH

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

(2009) Abhishek D. Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Calreticulin: non-endoplasmic reticulum functions in physiology and disease

(2009) Leslie I. Gold et al.   FASEB JOURNAL

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Immunogenic death of colon cancer cells treated with oxaliplatin

(2009) A Tesniere et al.   ONCOGENE

Oncolytic viruses: a novel form of immunotherapy

(2008) Robin J Prestwich et al.   Expert Review of Anticancer Therapy

Heat shock proteins: essential proteins for apoptosis regulation

(2008) D. Lanneau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY