Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

Noncanonical DNA structures are drivers of genome evolution

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Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

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G-quadruplex DNA structures in human stem cells and differentiation

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Alternative splicing modulation by G-quadruplexes

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Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer

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DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting

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High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios

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Targeting metabolic vulnerability in mitochondria conquers MEK inhibitor resistance in KRAS-mutant lung cancer

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DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody

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Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome

(2021) Wilfried M. Guiblet et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: a promising target for cancer therapy

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G-quadruplex structural variations in human genome associated with single-nucleotide variations and their impact on gene activity

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The different biological effects of TMPyP4 and cisplatin in the inflammatory microenvironment of osteosarcoma are attributed to G‐quadruplex

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Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome

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Ligand-induced native G-quadruplex stabilization impairs transcription initiation

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Genome-wide mapping of G-quadruplex structures with CUT&Tag

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Characterization of G-quadruplex formation in the ARID1A promoter

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PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs

(2020) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations

(2020) David S. M. Lee et al.   Nature Communications

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

The regulation and functions of DNA and RNA G-quadruplexes

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Expanded encyclopaedias of DNA elements in the human and mouse genomes

(2020) Jill E. Moore et al.   NATURE

Landscape of G-quadruplex DNA structural regions in breast cancer

(2020) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Detection of genomic G-quadruplexes in living cells using a small artificial protein

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The UCSC Genome Browser database: 2021 update

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The histone variant H2A.Z in gene regulation

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A Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters

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The International Genome Sample Resource (IGSR) collection of open human genomic variation resources

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Eukaryotic core promoters and the functional basis of transcription initiation

(2018) Vanja Haberle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

(2018) Niek van Wietmarschen et al.   Nature Communications

Noncanonical secondary structures arising from non-B DNA motifs are determinants of mutagenesis

(2018) Ilias Georgakopoulos-Soares et al.   GENOME RESEARCH

DNA G-quadruplex structures mold the DNA methylome

(2018) Shi-Qing Mao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Predicting causal variants affecting expression by using whole-genome sequencing and RNA-seq from multiple human tissues

(2017) Andrew Anand Brown et al.   NATURE GENETICS

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

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Non-Canonical G-quadruplexes cause the hCEB1 minisatellite instability in Saccharomyces cerevisiae

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Machine learning model for sequence-driven DNA G-quadruplex formation

(2017) Aleksandr B. Sahakyan et al.   Scientific Reports

Analysis of protein-coding genetic variation in 60,706 humans

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An expanded sequence context model broadly explains variability in polymorphism levels across the human genome

(2016) Varun Aggarwala et al.   NATURE GENETICS

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

TT-seq maps the human transient transcriptome

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Sambamba: fast processing of NGS alignment formats

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High-throughput sequencing of DNA G-quadruplex structures in the human genome

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PopGenome: An Efficient Swiss Army Knife for Population Genomic Analyses in R

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Potential non-B DNA regions in the human genome are associated with higher rates of nucleotide mutation and expression variation

(2014) Xiangjun Du et al.   NUCLEIC ACIDS RESEARCH

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(2013) A. Heger et al.   BIOINFORMATICS

Pif1 family helicases suppress genome instability at G-quadruplex motifs

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Quantitative visualization of DNA G-quadruplex structures in human cells

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Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles

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Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

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BEDTools: a flexible suite of utilities for comparing genomic features

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A novel G-quadruplex motif modulates promoter activity of human thymidine kinase 1

(2010) Richa Basundra et al.   FEBS Journal

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Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

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Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex

(2009) Ja Yil Lee et al.   NUCLEIC ACIDS RESEARCH

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The functional consequences of alternative promoter use in mammalian genomes

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