DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting

Oxidative Damage Induces a Vacancy G-Quadruplex That Binds Guanine Metabolites: Solution Structure of a cGMP Fill-in Vacancy G-Quadruplex in the Oxidized BLM Gene Promoter

(2022) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The solution structures of higher-order human telomere G-quadruplex multimers

(2021) Robert C Monsen et al.   NUCLEIC ACIDS RESEARCH

Structural recognition of the MYC promoter G-quadruplex by a quinoline derivative: insights into molecular targeting of parallel G-quadruplexes

(2021) Jonathan Dickerhoff et al.   NUCLEIC ACIDS RESEARCH

Evaluating Molecular Docking Software for Small Molecule Binding to G-Quadruplex DNA

(2021) Jonathan Dickerhoff et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Berberine Molecular Recognition of the Parallel MYC G-Quadruplex in Solution

(2021) Jonathan Dickerhoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solution Structure of Ternary Complex of Berberine Bound to a dGMP–Fill-In Vacancy G-Quadruplex Formed in the PDGFR-β Promoter

(2021) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

PDGFR-β Promoter Forms a Vacancy G-Quadruplex that Can be Filled-in by dGMP: Solution Structure and Molecular Recognition of Guanine Metabolites and Drugs

(2020) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes

(2020) Sreejana Ray et al.   ACS Chemical Biology

G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies

(2020) Josué Carvalho et al.   TRENDS IN MOLECULAR MEDICINE

Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

(2020) Guanhui Wu et al.   MOLECULES

Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G-Quadruplex and Downregulate MYC

(2019) Kai-Bo Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DDX5 helicase resolves G-quadruplex and is involved in MYC gene transcriptional activation

(2019) Guanhui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of 1:1 and 2:1 complexes of BMVC and MYC promoter G-quadruplex reveal a mechanism of ligand conformation adjustment for G4-recognition

(2019) Wenting Liu et al.   NUCLEIC ACIDS RESEARCH

Interplay of Guanine Oxidation and G-Quadruplex Folding in Gene Promoters

(2019) Aaron M. Fleming et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures

(2018) Clement Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The 3′-end region of the human PDGFR-β core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes

(2018) Buket Onel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A Dual-App Nucleoside Probe Provides Structural Insights into the Human Telomeric Overhang in Live Cells

(2018) Sudeshna Manna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding

(2018) Wenting Liu et al.   Nature Communications

Resolving the Ligand-Binding Specificity in c-MYC G-Quadruplex DNA: Absolute Binding Free Energy Calculations and SPR Experiment

(2017) Nanjie Deng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Consequences of Overlapping G-Quadruplexes and i-Motifs in the Platelet-Derived Growth Factor Receptor β Core Promoter Nuclease Hypersensitive Element Can Explain the Unexpected Effects of Mutations and Provide Opportunities for Selective Targeting of Both Structures by Small Molecules To Downregulate Gene Expression

(2017) Robert V. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

(2017) Christine E. Kaiser et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The effects of DNA supercoiling on G-quadruplex formation

(2017) Doreen A.T. Sekibo et al.   NUCLEIC ACIDS RESEARCH

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription

(2016) Buket Onel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

Selective Lighting Up of Epiberberine Alkaloid Fluorescence by Fluorophore-Switching Aptamer and Stoichiometric Targeting of Human Telomeric DNA G-Quadruplex Multimer

(2014) Lihua Zhang et al.   ANALYTICAL CHEMISTRY

The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

(2014) Samantha Kendrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA G-quadruplex and its potential as anticancer drug target

(2014) Buket Onel et al.   Science China-Chemistry

Solution structure of the major G-quadruplex formed in the human VEGF promoter in K+: insights into loop interactions of the parallel G-quadruplexes

(2013) Prashansa Agrawal et al.   NUCLEIC ACIDS RESEARCH

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K+ Solution

(2012) Yuwei Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer and Telomeres--An ALTernative to Telomerase

(2012) J. W. Shay et al.   SCIENCE

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

(2011) Robert V. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions

(2011) Robert Hänsel et al.   NUCLEIC ACIDS RESEARCH

c-MYC promoter G-quadruplex formed at the 5′-end of NHE III 1 element: insights into biological relevance and parallel-stranded G-quadruplex stability

(2011) Raveendra I. Mathad et al.   NUCLEIC ACIDS RESEARCH

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

(2010) Yong Qin et al.   BIOCHEMISTRY

Thermodynamic Stability and Folding Kinetics of the Major G-Quadruplex and Its Loop Isomers Formed in the Nuclease Hypersensitive Element in the Human c-Myc Promoter: Effect of Loops and Flanking Segments on the Stability of Parallel-Stranded Intramolecular G-Quadruplexes

(2010) Emmanuel Hatzakis et al.   BIOCHEMISTRY

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

I-Motif Structures Formed in the Human c-MYC Promoter Are Highly Dynamic–Insights into Sequence Redundancy and I-Motif Stability

(2010) Jixun Dai et al.   PLoS One

Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder

(2009) Hyun-Jin Kang et al.   BIOCHEMISTRY

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

(2009) SunMi L. Palumbo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures

(2009) Zhenjiang Zhang et al.   NUCLEIC ACIDS RESEARCH

Polymorphism of human telomeric quadruplex structures

(2008) Jixun Dai et al.   BIOCHIMIE

Intramolecularly folded G-quadruplex and i-motif structures in the proximal promoter of the vascular endothelial growth factor gene

(2008) K. Guo et al.   NUCLEIC ACIDS RESEARCH