Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

(2022) Rajendra Karki et al.   Science Immunology

Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions

(2022) Jessica A. Hensel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of immune genes is associated with the Black Death

(2022) Jennifer Klunk et al.   NATURE

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

(2022) R.K. Subbarao Malireddi et al.   Frontiers in Immunology

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

(2021) Zengzhang Zheng et al.   SCIENCE

The ‘cytokine storm’: molecular mechanisms and therapeutic prospects

(2021) Rajendra Karki et al.   TRENDS IN IMMUNOLOGY

RIPK1-Associated Inborn Errors of Innate Immunity

(2021) Jiahui Zhang et al.   Frontiers in Immunology

The evolution of regulated cell death pathways in animals and their evasion by pathogens

(2021) Bart Tummers et al.   PHYSIOLOGICAL REVIEWS

The J2-Immortalized Murine Macrophage Cell Line Displays Phenotypical and Metabolic Features of Primary BMDMs in Their M1 and M2 Polarization State

(2021) Iolanda Spera et al.   Cancers

RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events

(2020) Tom Delanghe et al.   TRENDS IN CELL BIOLOGY

A comprehensive guide to studying inflammasome activation and cell death

(2020) Rebecca E. Tweedell et al.   Nature Protocols

PANoptosis in microbial infection

(2020) David E Place et al.   CURRENT OPINION IN MICROBIOLOGY

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Activity of caspase-8 determines plasticity between cell death pathways

(2019) Kim Newton et al.   NATURE

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease

(2019) Najoua Lalaoui et al.   NATURE

A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1

(2019) Panfeng Tao et al.   NATURE

Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

(2019) Mary Speir et al.   NATURE IMMUNOLOGY

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing

(2018) Marinella G. Callow et al.   Cell Death & Disease

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

(2018) Daichao Xu et al.   CELL

TAK1 mediates convergence of cellular signals for death and survival

(2018) Sabreena Aashaq et al.   APOPTOSIS

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

(2017) Julia Joung et al.   Nature Protocols

Molecular history of plague

(2016) M. Drancourt et al.   CLINICAL MICROBIOLOGY AND INFECTION

Yersinia versus host immunity: how a pathogen evades or triggers a protective response

(2016) Lawton K Chung et al.   CURRENT OPINION IN MICROBIOLOGY

YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase Activity

(2016) Ka-Wai Ma et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2

(2016) Niroshika M. Keppetipola et al.   RNA

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation

(2015) Jonathan L. Schmid-Burgk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Yersinia pestis: one pandemic, two pandemics, three pandemics, more?

(2014) M Thomas P Gilbert   LANCET INFECTIOUS DISEASES

Yersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysis

(2014) David M Wagner et al.   LANCET INFECTIOUS DISEASES

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Serine/threonine acetylation of TGF -activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling

(2012) N. Paquette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A draft genome of Yersinia pestis from victims of the Black Death

(2011) Kirsten I. Bos et al.   NATURE

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation

(2009) James Schuman et al.   BLOOD

Comprehending the complex connection between PKCβ, TAK1, and IKK in BCR signaling

(2009) Hisaaki Shinohara et al.   IMMUNOLOGICAL REVIEWS

TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis

(2009) James E. Vince et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

(2008) Minghui Tang et al.   JOURNAL OF EXPERIMENTAL MEDICINE