ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Authors
Keywords
-
Journal
Science Immunology
Volume -, Issue -, Pages -
Publisher
American Association for the Advancement of Science (AAAS)
Online
2022-05-20
DOI
10.1126/sciimmunol.abo6294
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
- (2022) Jeremy Di Domizio et al. NATURE
- Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19
- (2022) Jennifer Hammond et al. NEW ENGLAND JOURNAL OF MEDICINE
- Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19
- (2022) Avraham Unterman et al. Nature Communications
- Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system
- (2021) Qingyuan Zhu et al. ANTIVIRAL RESEARCH
- Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity
- (2021) Daisy A. Hoagland et al. IMMUNITY
- SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO
- (2021) Jing Wu et al. Cell Reports
- A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood
- (2021) Dianna L. Ng et al. Science Advances
- COVID-19 vaccine challenges: What have we learned so far and what remains to be done?
- (2021) Rebecca Forman et al. HEALTH POLICY
- SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling pathways
- (2021) Lulu Han et al. JOURNAL OF MEDICAL VIROLOGY
- Activation of STING signaling pathway effectively blocks human coronavirus infection
- (2021) Wei Liu et al. JOURNAL OF VIROLOGY
- Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
- (2021) Junji Xing et al. Nature Communications
- Direct Derivation of Human Alveolospheres for SARS-CoV-2 Infection Modeling and Drug Screening
- (2021) Toshiki Ebisudani et al. Cell Reports
- SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1
- (2021) Liyan Sui et al. Frontiers in Immunology
- ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
- (2021) GuanQun Liu et al. Nature Microbiology
- A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
- (2021) Fiachra Humphries et al. Science Immunology
- Pharmacological activation of STING blocks SARS-CoV-2 infection
- (2021) Minghua Li et al. Science Immunology
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
- (2021) SangJoon Lee et al. NATURE
- Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
- (2021) J. Loske et al. NATURE BIOTECHNOLOGY
- Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
- (2021) Shuai Wang et al. NATURE CELL BIOLOGY
- Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
- (2021) Jack Chun-Chieh Hsu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block
- (2021) James M. Burke et al. RNA
- The ‘cytokine storm’: molecular mechanisms and therapeutic prospects
- (2021) Rajendra Karki et al. TRENDS IN IMMUNOLOGY
- A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome
- (2021) Doyeon Kim et al. Nature Communications
- Comprehensive Transcriptomic Analysis Identifies Novel Antiviral Factors Against Influenza A Virus Infection
- (2021) Ao Zhou et al. Frontiers in Immunology
- CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death
- (2021) Yves Lévy et al. iScience
- An open-label randomized controlled trial of the effect of lopinavir/ritonavir, lopinavir/ritonavir plus IFN-β-1a and hydroxychloroquine in hospitalized patients with COVID-19
- (2021) Florence Ader et al. CLINICAL MICROBIOLOGY AND INFECTION
- A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
- (2021) Tianyang Mao et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients
- (2021) Angélica Jayk Bernal et al. NEW ENGLAND JOURNAL OF MEDICINE
- ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis
- (2021) Rajendra Karki et al. Cell Reports
- Efficacy of interferon beta-1a plus remdesivir compared with remdesivir alone in hospitalised adults with COVID-19: a double-bind, randomised, placebo-controlled, phase 3 trial
- (2021) Andre C Kalil et al. Lancet Respiratory Medicine
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- An interactive web-based dashboard to track COVID-19 in real time
- (2020) Ensheng Dong et al. LANCET INFECTIOUS DISEASES
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense
- (2020) Min Zheng et al. CELL
- The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
- (2020) Sannula Kesavardhana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
- (2020) Michael Devos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
- (2020) Ivan Fan-Ngai Hung et al. LANCET
- Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation
- (2020) Huipeng Jiao et al. NATURE
- Gut stem cell necroptosis by genome instability triggers bowel inflammation
- (2020) Ruicong Wang et al. NATURE
- Remdesivir for the Treatment of Covid-19 — Preliminary Report
- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Rapid COVID-19 vaccine development
- (2020) Barney S. Graham SCIENCE
- Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)
- (2020) Shelbi Christgen et al. Frontiers in Cellular and Infection Microbiology
- Interferon-α2b Treatment for COVID-19
- (2020) Qiong Zhou et al. Frontiers in Immunology
- Using social and behavioural science to support COVID-19 pandemic response
- (2020) Jay J. Van Bavel et al. Nature Human Behaviour
- Efficacy and safety of interferon β-1a in treatment of severe COVID-19: A randomized clinical trial
- (2020) Effat Davoudi-Monfared et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients
- (2020) Nan Wang et al. Cell Host & Microbe
- Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
- (2020) Marcel Doerflinger et al. IMMUNITY
- Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
- (2020) Min Zheng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Longitudinal analyses reveal immunological misfiring in severe COVID-19
- (2020) Carolina Lucas et al. NATURE
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
- (2020) Matthias Thoms et al. SCIENCE
- Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
- (2020) Jack Major et al. SCIENCE
- Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer
- (2020) Rajendra Karki et al. JCI Insight
- Apoptosis (programmed cell death) and its signals - A review
- (2020) E. Obeng BRAZILIAN JOURNAL OF BIOLOGY
- A comprehensive guide to studying inflammasome activation and cell death
- (2020) Rebecca E. Tweedell et al. Nature Protocols
- The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
- (2020) Jin-Yan Li et al. VIRUS RESEARCH
- Evasion of Type I Interferon by SARS-CoV-2
- (2020) Hongjie Xia et al. Cell Reports
- Large-Scale Multi-omic Analysis of COVID-19 Severity
- (2020) Katherine A. Overmyer et al. Cell Systems
- Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes
- (2020) Rajendra Karki et al. CELL
- ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis)
- (2020) Balaji Banoth et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison
- (2020) Ioanna-Evdokia Galani et al. NATURE IMMUNOLOGY
- Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Cytokine Storm
- (2020) David C. Fajgenbaum et al. NEW ENGLAND JOURNAL OF MEDICINE
- Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
- (2020) Andre C. Kalil et al. NEW ENGLAND JOURNAL OF MEDICINE
- SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production
- (2020) Keli Chen et al. Viruses-Basel
- IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
- (2019) Rudragouda Channappanavar et al. JOURNAL OF CLINICAL INVESTIGATION
- Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease
- (2019) R.K. Subbarao Malireddi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation
- (2018) R.K. Subbarao Malireddi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Necroptosis: a regulated inflammatory mode of cell death
- (2018) Yogesh K. Dhuriya et al. Journal of Neuroinflammation
- MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape
- (2018) Vineet D. Menachery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The coronavirus nucleocapsid protein is ADP-ribosylated
- (2018) Matthew E. Grunewald et al. VIROLOGY
- Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
- (2017) Julia Joung et al. Nature Protocols
- Complex heatmaps reveal patterns and correlations in multidimensional genomic data
- (2016) Zuguang Gu et al. BIOINFORMATICS
- DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death
- (2016) Roshan J. Thapa et al. Cell Host & Microbe
- NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis
- (2016) Prajwal Gurung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
- (2015) Wan-ting He et al. CELL RESEARCH
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Guarding the frontiers: the biology of type III interferons
- (2015) Andreas Wack et al. NATURE IMMUNOLOGY
- limma powers differential expression analyses for RNA-sequencing and microarray studies
- (2015) Matthew E. Ritchie et al. NUCLEIC ACIDS RESEARCH
- The Molecular Signatures Database Hallmark Gene Set Collection
- (2015) Arthur Liberzon et al. Cell Systems
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes
- (2014) P. Gurung et al. JOURNAL OF IMMUNOLOGY
- Dietary modulation of the microbiome affects autoinflammatory disease
- (2014) John R. Lukens et al. NATURE
- The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
- (2013) James M. Murphy et al. IMMUNITY
- The JAK-STAT Pathway at Twenty
- (2012) George R. Stark et al. IMMUNITY
- DDX60, a DEXD/H Box Helicase, Is a Novel Antiviral Factor Promoting RIG-I-Like Receptor-Mediated Signaling
- (2011) M. Miyashita et al. MOLECULAR AND CELLULAR BIOLOGY
- Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
- (2011) Andrew Oberst et al. NATURE
- Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes
- (2010) R. K. S. Malireddi et al. JOURNAL OF IMMUNOLOGY
- DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB
- (2009) Manuele Rebsamen et al. EMBO REPORTS
- Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes
- (2008) Mohamed Lamkanfi et al. MOLECULAR & CELLULAR PROTEOMICS
- TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
- (2008) Ken J. Ishii et al. NATURE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation