Article
Biochemistry & Molecular Biology
Diqi Yang, Ruiling Yin, Qianghui Lei, Jiandi Zhu, Sha Nan, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: Baicalin alleviates endometrial inflammatory injury by regulating autophagy and influencing the redistribution of TJ proteins, providing a new therapeutic approach for preventing embryo loss and endometritis.
Review
Chemistry, Applied
Biswajita Pradhan, Laxmidhar Rout, Jang-Seu Ki
Summary: Porphyran, a polysaccharide found in red seaweeds, has immunomodulatory, anti-inflammatory, and anti-cancer effects by boosting immunity and targeting apoptotic molecules, making it a potential chemotherapeutic or chemopreventive drug.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Medicinal
Alisha Ansari, Anuradha Seth, Mukul Dutta, Tooba Qamar, Sarita Katiyar, Arvind K. Jaiswal, Ankita Rani, Swetapadma Majhi, Mukesh Kumar, Rabi S. Bhatta, Rajdeep Guha, Kalyan Mitra, Koneni Sashidhara, Susanta Kar
Summary: In this study, a series of quinazolinone-based acetamide derivatives were synthesized and evaluated for their anti-leishmanial activity. Compounds F12, F27, and F30 exhibited remarkable activity against L. donovani in vitro. Oral administration of F12 and F27 significantly reduced parasite burden in infected mice and hamsters. Mechanistic studies revealed the inhibition of the PI3K/Akt/CREB axis by F27, resulting in a shift from IL-10 to IL-12 release in macrophages. In silico studies suggested that F27 inhibits Leishmania prolyl-tRNA synthetase, leading to programmed cell death of the parasite.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Physiology
Bo-Zong Shao, Yi Yao, Jun-Shan Zhai, Jian-Hua Zhu, Jin-Ping Li, Kai Wu
Summary: IBD, including UC and CD, is an idiopathic intestinal inflammatory disease, where autophagy plays a vital role. Understanding the regulation of autophagy in IBD is crucial for developing novel therapeutic strategies.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Hematology
Lindsay Canham, Sam Sendac, Mannekomba R. Diagbouga, Elena Wolodimeroff, Daniela Pirri, Blanca Tardajos Ayllon, Shuang Feng, Celine Souilhol, Timothy J. A. Chico, Paul C. Evans, Jovana Serbanovic-Canic
Summary: Hemodynamic wall shear stress (WSS) exerted on the endothelium by flowing blood determines the spatial distribution of atherosclerotic lesions. Disturbed flow (DF) with low WSS promotes atherosclerosis, while unidirectional flow with high WSS is protective. This study investigates the role of EVA1A in WSS-regulated endothelial cell dysfunction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Microbiology
Ehsan Ahmadpour, Farhad Babaie, Tohid Kazemi, Sirous Mehrani Moghaddam, Ata Moghimi, Ramin Hosseinzadeh, Veeranoot Nissapatorn, Abdol Sattar Pagheh
Summary: Toxoplasma gondii is an obligate intracellular parasite that creates a parasitophorous vacuole during invasion to modulate host cell functions. It has effective strategies to escape immune responses and remain inactive in tissue cysts. The secretory organelles of T. gondii, containing proteins that mediate recognition and entry into host cells, play a crucial role in these processes.
Review
Food Science & Technology
Huanquan Chen, Junyan Zhang, Ying He, Zhuoyi Lv, Zhengtong Liang, Jianze Chen, Peishan Li, Jiawei Liu, Hongchen Yang, Ailin Tao, Xueting Liu
Summary: Staphylococcus aureus, a common bacterium, plays a crucial role in various diseases. This article discusses its virulence factors, inflammatory responses, host cell death, and associated diseases, highlighting the importance of understanding its pathogenic mechanisms for targeted treatment.
Article
Immunology
Qiuxiang Cai, Yajuan Li, Yung-Fu Chang, Zhaoxin Tang, Hui Zhang, Qingmei Xie
Summary: This study investigated the host response to Pasteurella multocida (PM) infection using a duck model. The results indicated that PM infection induces inflammation in liver tissue, which leads to complex interactions between inflammation, apoptosis, and autophagy signaling pathways.
MICROBIAL PATHOGENESIS
(2023)
Review
Virology
Di Zhang, Zhuang Ding, Xiaohong Xu
Summary: "Newcastle disease (ND) poses a consistent risk to the poultry industry and is a potential candidate for antitumor treatment. This review summarizes the advances in understanding the pathogenic mechanism of Newcastle disease virus (NDV) in the last two decades. It covers the correlation between the protein structure of the virus and its pathogenic ability, lymph tissue damage, cytokine involvement in virulence, and host's defense mechanisms against the virus."
Article
Immunology
Neha Sharma, Mohd Shariq, Neha Quadir, Jasdeep Singh, Javaid A. Sheikh, Seyed E. Hasnain, Nasreen Z. Ehtesham
Summary: The PE6 protein of Mycobacterium tuberculosis interacts with TLR4 on macrophages to activate the NF kappa B signaling pathway, leading to secretion of proinflammatory cytokines. Additionally, PE6 induces apoptosis through activation of Caspases and endoplasmic reticulum-associated unfolded protein response pathways. Interestingly, PE6 also suppresses autophagy and binds DNA, potentially aiding in virulence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Laura Fernandez-Prades, Mariano Brasal-Prieto, Gonzalo Alba, Victoria Martin, Sergio Montserrat-de la Paz, Marta Cejudo-Guillen, Consuelo Santa-Maria, Hala Dakhaoui, Beatriz Granados, Francisco Sobrino, Francisca Palomares, Soledad Lopez-Enriquez
Summary: This study found that sulforaphane (SFN) has immunomodulatory effects on monocyte-derived dendritic cells (moDCs), reducing autophagy and enhancing apoptosis. SFN also decreased the expression of markers and cytokine levels, leading to a regulatory profile shift in moDCs/T cells. These findings suggest that SFN may have potential as a treatment for inflammatory pathologies.
Review
Biology
Eun-Ji Lee, Hyun-Jeong Kim, Min Sik Choi, Ji-Eun Chang
Summary: Inflammation is closely related to cancer development, with inflammatory cells and the cytokines they produce playing a key role. Autophagy, a cell self-degradation process, may also be regulated by cancer-associated inflammatory signaling pathways. Understanding the specific functions of autophagy in cancer inflammatory responses is important for enhancing anti-cancer effects.
Article
Biology
Marine Jacquet, Eric Hervouet, Timothee Baudu, Michael Herfs, Chloe Parratte, Jean-Paul Feugeas, Valerie Perez, Celia Reynders, Marie Ancion, Marc Vigneron, Aurelie Baguet, Michael Guittaut, Annick Fraichard, Gilles Despouy
Summary: The study shows that the autophagy-related gene GABARAPL1 is associated with EMT regulation in non-small cell lung cancer, while the ATG8 proteins in the selective autophagy pathway may be involved in EMT regulation as well. Results suggest that GABARAPL1 in lung adenocarcinoma cells plays a role in EMT regulation by mediating the degradation of SMAD proteins.
Article
Biochemistry & Molecular Biology
Jinliang Li, Suping Chen, Feilong Wang, Jingyu Zhang, Mohammad Ali Zeyghami, Faramarz Koohsar, Ali Asghar Ayatollahi, Abolfazl Amini
Summary: Growing evidence has shown that seizures can trigger inflammation by increasing the expression of inflammatory cytokines. This study investigated the inhibitory effect of rosiglitazone on PTZ-induced kindling by affecting the inflammatory pathway. The results suggest that rosiglitazone may have a crucial role in protecting against neuronal damage caused by PTZ-induced seizure.
NEUROCHEMICAL RESEARCH
(2023)
Article
Environmental Sciences
Junbo Li, Kai Yin, Lulu Hou, Yue Zhang, Hongmin Lu, Chengxue Ma, Mingwei Xing
Summary: Researchers found that microplastics have little attention on immune organs. In an experiment on chickens, poly-styrene microplastics were found to affect the thymus index by causing cellular infiltration and oxidative stress. The study also revealed the activation of several signaling pathways related to thymus inflammation, apoptosis, and autophagy.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Review
Cell Biology
Asiya Batool, Sabreena Aashaq, Khurshid Iqbal Andrabi
EUROPEAN JOURNAL OF CELL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Ghazia Shah, Nadiem Nazir, Khurshid Iqbal Andrabi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemistry & Molecular Biology
Asiya Batool, Sabreena Aashaq, Khurshid I. Andrabi
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Nadiem Nazir Bhat, Khurshid Iqbal Andrabi
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Asiya Batool, Sheikh Tahir Majeed, Sabreena Aashaq, Rabiya Majeed, Khurshid Iqbal Andrabi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Review
Cell Biology
Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi, Zaffar Amin Shah
Summary: TGF-beta serves as a dual role in tumor progression, acting both as a tumor suppressor in the early stages and a metastatic promoter in the later stages. The signaling pathways of TGF-beta are complex, involving both SMAD-dependent and SMAD-independent pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Asma Rafiq, Sabreena Aashaq, Iqra Jan, Mushtaq A. Beigh
Summary: Sine Oculis Homeobox 1 (SIX1) is a vital member of the homeobox transcription factor family, playing crucial roles in organismal development and differentiation. Its aberrant expression has been linked to hearing impairment, renal anomalies, and tumorigenesis, highlighting its importance in various pathological conditions. As a transcription factor, SIX1 primarily regulates cellular functions by controlling the expression of different proteins.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
