CRISPR whole-genome screening identifies new necroptosis regulators and RIPK1 alternative splicing

The in vivo evidence for regulated necrosis

(2017) Wulf Tonnus et al.   IMMUNOLOGICAL REVIEWS

Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

(2016) Xiaochang Zhang et al.   CELL

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Biomarkers for the detection of necroptosis

(2016) Sudan He et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

(2016) Sebastian A Wagner et al.   EMBO JOURNAL

SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

(2016) Lisa Schlicher et al.   EMBO REPORTS

Controlled detonation: evolution of necroptosis in pathogen defense

(2016) Michelle Brault et al.   IMMUNOLOGY AND CELL BIOLOGY

N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

(2016) Ruifan Wu et al.   MOLECULAR BIOTECHNOLOGY

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

(2016) Paul R. Elliott et al.   MOLECULAR CELL

Validation of Synthetic CRISPR Reagents as a Tool for Arrayed Functional Genomic Screening

(2016) Jenille Tan et al.   PLoS One

PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing

(2016) John K. Vuong et al.   Cell Reports

PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons

(2016) Jonathan P. Ling et al.   Cell Reports

SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

(2016) Sebastian Kupka et al.   Cell Reports

Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

(2016) Somsakul Pop Wongpalee et al.   eLife

Multifaceted role of the ubiquitin ligase Itch in immune regulation

(2015) K Venuprasad et al.   IMMUNOLOGY AND CELL BIOLOGY

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

RIPK1 and RIPK3: critical regulators of inflammation and cell death

(2015) Kim Newton   TRENDS IN CELL BIOLOGY

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

(2014) James A. Rickard et al.   CELL

RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3

(2014) Christopher P. Dillon et al.   CELL

In vivo analysis of formation and endocytosis of the Wnt/ -Catenin signaling complex in zebrafish embryos

(2014) A. I. H. Hagemann et al.   JOURNAL OF CELL SCIENCE

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition

(2014) W. J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From endosomes to the trans-Golgi network

(2014) Lei Lu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

Novel Insights into V-ATPase Functioning: Distinct Roles for its Accessory Subunits ATP6AP1/Ac45 and ATP6AP2/(pro) Renin Receptor

(2012) Eric J.R. Jansen et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Ric1-Rgp1 Complex Is a Guanine Nucleotide Exchange Factor for the Late Golgi Rab6A GTPase and an Effector of the Medial Golgi Rab33B GTPase

(2012) Ganesh V. Pusapati et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport

(2011) Orly Laufman et al.   JOURNAL OF CELL BIOLOGY

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

It takes two to tango: a new couple in the family of ubiquitin-editing complexes

(2011) Ingrid E Wertz   NATURE IMMUNOLOGY

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

(2011) Neesar Ahmed et al.   NATURE IMMUNOLOGY

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

(2010) Y-T Wu et al.   CELL DEATH AND DIFFERENTIATION

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

Poly(C)-binding proteins as transcriptional regulators of gene expression

(2009) Hack Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

(2009) J Silke et al.   CELL DEATH AND DIFFERENTIATION

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Splign: algorithms for computing spliced alignments with identification of paralogs

(2008) Yuri Kapustin et al.   Biology Direct

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

(2008) Noula Shembade et al.   NATURE IMMUNOLOGY