Article
Respiratory System
Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevao, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger
Summary: Mycoplasma pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Yibin Yang, Xia Zhu, Haixin Zhang, Yuhua Chen, Yi Song, Xiaohui Ai
Summary: The study on the host-pathogen interaction between channel catfish and Yersinia ruckeri revealed the dynamic regulation of the transcriptome during infection, with significant upregulation of immune-related pathways. Specifically, the infection was found to be closely related to metabolic pathways, and the pathogenesis promoted by Y. ruckeri in channel catfish was mainly through the flagellum gene fliC. This research contributes to understanding how catfish respond to infection and develop enteric red mouth disease (ERM) through a transcriptional perspective.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjie Yang, Yang Li, Diana Boraschi
Summary: Plastic pollution is a global problem that poses risks to the environment and human health. Discarded plastic degrades into microplastics (MPs) in the environment, which can interact with microorganisms and biomolecules. These interactions can modify the characteristics of microbes and biomolecules, potentially affecting the immune response and leading to risks to human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Eleanor K. P. Marshall, Marc S. Dionne
Summary: Fruit fly Drosophila melanogaster has emerged as an important model for studying host-pathogen interactions, particularly in the context of mycobacterial infections. Studies using Drosophila have identified key factors involved in controlling or resisting mycobacterial infections, laying the groundwork for further research into the interaction between host and pathogen factors. The development of genetic tools for manipulating mycobacterial genomes holds promise for more detailed investigations using the fruit fly model, although its full potential has yet to be fully realized.
MOLECULAR MICROBIOLOGY
(2022)
Review
Microbiology
Jingjing Luo, Lidong Wang, Lei Song, Zhao-Qing Luo
Summary: Ubiquitination is a commonly used post-translational modification in eukaryotic cells that plays a crucial role in immune responses. Pathogens like Legionella pneumophila utilize ubiquitin signaling to modulate host cell processes, support replication, and manipulate ubiquitin signaling through effector proteins.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yao Zhao, Bo Yang, Huawei Xu, Jinbin Wu, Zhiyang Xu, Yuanchao Wang
Summary: The oomycete pathogen Phytophthora sojae secretes RXLR effectors to suppress host immune responses, promoting infection. The virulence effector Avh94 stabilizes the repressor JAZ1/2 of the jasmonic acid (JA) signaling pathway to inhibit JA signaling, thereby enhancing infection.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biology
M. A. Hanson, S. Kondo, B. Lemaitre
Summary: Antimicrobial peptides (AMPs) play a crucial role in defending against infection in plants and animals. A study on Drosophila has revealed that the Drosocin gene encodes two prominent host defense peptides with different specificities against distinct pathogens.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Rajashri Shende, Sarah Sze Wah Wong, Heikrujam Thoihen Meitei, Girdhari Lal, Taruna Madan, Vishukumar Aimanianda, Jayanta Kumar Pal, Arvind Sahu
Summary: Invasive aspergillosis is a life-threatening fungal infection for immunocompromised hosts. The study found that complement deficiency increases susceptibility to systemic infection by Aspergillus fumigatus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Virology
Samantha Lisy, Katherine Rothamel, Manuel Ascano
Summary: RBPs, as intracellular host factors that interact with RNA virus genomes, have a profound impact on infection outcomes. Recent discoveries from new methodologies have led to a reevaluation of RBPs and post-transcriptional gene regulation, highlighting how RBPs can impact the fates of cellular and viral RNA in conflicting ways. Noncanonical RBPs, initially characterized through interactions with viral RNA, may have roles beyond viral pathogenesis, challenging the discrimination between cellular and viral RNA for exerting either pro- or antiviral effects.
Article
Agriculture, Multidisciplinary
Jie Zhang, Junaid Zafar, Jinrong Kong, Fei Wang, Xuehua Shao, Ruonan Zhang, Rui Pang, Hanhong Xu, Xiaoxia Xu, Fengliang Jin
Summary: This study investigates the immune response of Spodoptera frugiperda to Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection, identifying Toll, IMD, and apoptosis pathways as primary immune responses. The study also discovers that AcMNPV induces differential expression of microRNAs (miRNAs) in the host, which negatively regulate the host's antiviral immune genes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Microbiology
Anna Bereznicka, Krzysztof Mikolajczyk, Marcin Czerwinski, Radoslaw Kaczmarek
Summary: Glycosphingolipids (GSLs) are important components of cell membranes and play crucial roles in signal transduction, regulation, and cell proliferation. Many pathogens target GSLs as receptors to attach to host cell surfaces, but the role of GSLs as pathogen receptors is often overlooked.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vladimir Lazetic, Emily R. Troemel
Summary: One of the strongest drivers in evolution is the struggle to survive a host-pathogen battle, which selects for diversity among the factors involved in the battle. This diversification results in immune factors with non-conserved sequences across species. In addition to diversification, host-pathogen battles can lead to an amplification in gene number and the formation of large gene families with sequence specific to particular strains or species.
Article
Immunology
Anne Marie Krachler, Natalie Sirisaengtaksin, Pauline Monteith, C. E. Timothy Paine, Christopher J. Coates, Jenson Lim
Summary: Adhesins play a crucial role in bacterial colonization and invasion of host tissues, but their impact on immune-mediated damage and pathogenesis remains unclear. This study investigated the role of Y. pseudotuberculosis MAM in pathogenesis during infection of the Galleria mellonella insect model, showing that MAM is essential for efficient bacterial binding and uptake by host phagocytes, with loss of MAM increasing pathogenicity and bacterial clearance. Additionally, failure to engage phagocytes led to hyperactivation of humoral immune responses and increased host mortality.
Article
Biochemistry & Molecular Biology
Da Di, Jeanne Simon Thomas, Mathias Currat, Jose Manuel Nunes, Alicia Sanchez-Mazas
Summary: In this study, DNA was extracted from medieval plague victims and compared to modern populations to investigate changes in human leukocyte antigen (HLA) genotypes. The authors found significant differences in HLA frequencies between ancient and modern populations, suggesting a long-term effect of Yersinia pestis on human immunity genes. However, further analyses and simulations did not support these conclusions, indicating that ancient DNA may not provide sufficient evidence for HLA protection or susceptibility to plague.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)