Activators of Nrf2 to Counteract Neurodegenerative Diseases

Nrf2 Expression Is Decreased in LRRK2 Transgenic Mouse Brain and LRRK2 Overexpressing SH-SY5Y Cells

(2023) Fumitaka Kawakami et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury

(2022) Yaoqiang Lao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease

(2022) Amritha Chakkittukandiyil et al.   NEUROCHEMISTRY INTERNATIONAL

A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator

(2022) Jie Guo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction

(2022) Wing-Yu Fu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Normal and Pathological NRF2 Signalling in the Central Nervous System

(2022) Tony Heurtaux et al.   Antioxidants

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

(2022) Enrique Crisman et al.   MEDICINAL RESEARCH REVIEWS

Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease

(2022) Yuanyuan Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Contribution of astrocytes to neuropathology of neurodegenerative diseases

(2021) Cigdem Acioglu et al.   BRAIN RESEARCH

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

(2021) Yuta Horie et al.   Communications Biology

Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer’s disease

(2021) Lailiang Qu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy

(2021) Mohammed Salah Ayoup et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation

(2021) Pan Jiang et al.   NEUROCHEMICAL RESEARCH

Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms

(2021) Pavan Thapak et al.   NEUROMOLECULAR MEDICINE

Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes

(2021) Sentiljana Gumeni et al.   Cell Death & Disease

Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man

(2021) Sergey A. Sinenko et al.   Frontiers in Cell and Developmental Biology

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction

(2021) David Norton et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease

(2021) Manuj Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The KEAP1-NRF2 System in Healthy Aging and Longevity

(2021) Daisuke Matsumaru et al.   Antioxidants

The NRF2-Dependent Transcriptional Regulation of Antioxidant Defense Pathways: Relevance for Cell Type-Specific Vulnerability to Neurodegeneration and Therapeutic Intervention

(2021) Stephanie M. Boas et al.   Antioxidants

The β-secretase BACE1 in Alzheimer’s disease

(2020) Harald Hampel et al.   BIOLOGICAL PSYCHIATRY

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties

(2020) Clara Herrera-Arozamena et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease

(2020) Ruiling Xu et al.   International Journal of Nanomedicine

Microglia and Parkinson's disease: footprints to pathology

(2020) Ekaterina Lazdon et al.   JOURNAL OF NEURAL TRANSMISSION

Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

(2020) Sumi Lee et al.   MEDICINAL CHEMISTRY RESEARCH

Biological and therapeutic activities of thymoquinone: Focus on the Nrf2 signaling pathway

(2020) Marjan Talebi et al.   PHYTOTHERAPY RESEARCH

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

(2020) Laura Casares et al.   Redox Biology

Generation of potent Nrf2 activators via tuning the electrophilicity and steric hindrance of vinyl sulfones for neuroprotection

(2020) Zi-Long Song et al.   BIOORGANIC CHEMISTRY

Development and optimization of halogenated vinyl sulfones as Nrf2 activators for the treatment of Parkinson’s disease

(2020) Ji Won Choi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis

(2019) Surabhi Mehra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Microglia and the Aging Brain: Are Senescent Microglia the Key to Neurodegeneration?

(2019) Dafina M. Angelova et al.   JOURNAL OF NEUROCHEMISTRY

Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro

(2019) Mustafa T. Ardah et al.   NEUROCHEMISTRY INTERNATIONAL

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells

(2019) Hongzhi Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model

(2019) Hyeon Jeong Kim et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Alzheimer’s Disease Pharmacotherapy in Relation to Cholinergic System Involvement

(2019) Gabriela Dumitrita Stanciu et al.   Biomolecules

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy

(2018) Ana I. Rojo et al.   Redox Biology

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus

(2018) Claudia Jara et al.   Redox Biology

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Optimization of Vinyl Sulfone Derivatives as Potent Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators for Parkinson’s Disease Therapy

(2018) Ji Won Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bach1: Function, Regulation, and Involvement in Disease

(2018) Xinyue Zhang et al.   Oxidative Medicine and Cellular Longevity

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Stress-sensing mechanisms and the physiological roles of the Keap1–Nrf2 system during cellular stress

(2017) Takafumi Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidases in Parkinson’s disease: a systematic review

(2017) Karim Belarbi et al.   Molecular Neurodegeneration

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2: a modulator of Parkinson’s disease?

(2016) Michael Todorovic et al.   JOURNAL OF NEURAL TRANSMISSION

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders

(2016) Cristina Maccallini et al.   Neural Regeneration Research

The BACE1 inhibitor verubecestat (MK-8931) reduces CNS  -amyloid in animal models and in Alzheimers disease patients

(2016) M. E. Kennedy et al.   Science Translational Medicine

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

(2015) Li-Li Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thymoquinone and its therapeutic potentials

(2015) Sara Darakhshan et al.   PHARMACOLOGICAL RESEARCH

α-Synuclein as a ferrireductase

(2015) David R. Brown   BIOCHEMICAL SOCIETY TRANSACTIONS

Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

(2014) Cliona Stack et al.   HUMAN MOLECULAR GENETICS

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

(2014) Seo Yeon Woo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Keap Calm, and Carry on Covalently

(2013) Anthony J. Wilson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Parkinson's disease-related genes act in mitochondrial homeostasis

(2012) Yan Sai et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

(2011) Vineet Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

Different Susceptibility to the Parkinson's Toxin MPTP in Mice Lacking the Redox Master Regulator Nrf2 or Its Target Gene Heme Oxygenase-1

(2010) Nadia G. Innamorato et al.   PLoS One

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

(2008) J. Ramesh Babu et al.   JOURNAL OF NEUROCHEMISTRY

Thymoquinone protects dopaminergic neurons against MPP+and rotenone

(2008) Khaled Radad et al.   PHYTOTHERAPY RESEARCH