Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury

Neurotherapeutic Effect of Inula britannica var. Chinensis against H2O2-Induced Oxidative Stress and Mitochondrial Dysfunction in Cortical Neurons

(2021) Jin Young Hong et al.   Antioxidants

Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents

(2021) PinFen Chua et al.   Scientific Reports

Design, synthesis, and evaluation of N-benzylpyrrolidine and 1,3,4-oxadiazole as multitargeted hybrids for the treatment of Alzheimer’s disease

(2021) Priyanka Kumari Choubey et al.   BIOORGANIC CHEMISTRY

Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer’s disease

(2021) Lailiang Qu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy

(2021) Mohammed Salah Ayoup et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway

(2021) Nashwa Amin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

9-Methylfascaplysin exerts anti-ischemic stroke neuroprotective effects via the inhibition of neuroinflammation and oxidative stress in rats

(2021) Difan Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Activation of Adenosine A1 Receptor in Ischemic Stroke: Neuroprotection by Tetrahydroxy Stilbene Glycoside as an Agonist

(2021) Lingyu Ruan et al.   Antioxidants

An Edaravone-Guided Design of a Rhodamine-Based Turn-on Fluorescent Probe for Detecting Hydroxyl Radicals in Living Systems

(2021) Liqin Chen et al.   ANALYTICAL CHEMISTRY

Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents

(2020) Linghao Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats

(2020) Jing Yu et al.   Oxidative Medicine and Cellular Longevity

Management of acute ischemic stroke

(2020) Michael S Phipps et al.   BMJ-British Medical Journal

Targeting Oxidative Stress and Inflammation to Prevent Ischemia-Reperfusion Injury

(2020) Liquan Wu et al.   Frontiers in Molecular Neuroscience

Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone

(2020) Christian Bailly et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration

(2020) Arooj Mohsin Alvi et al.   Biomolecules

Comparative assessment of neurotoxicity impacts induced by alkyl tri‐n‐butyl phosphate and aromatic tricresyl phosphate in PC12 cells

(2020) Yeqian Chang et al.   ENVIRONMENTAL TOXICOLOGY

Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK/Nrf2 pathway

(2020) Hui Xu et al.   Journal of Advanced Research

MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system

(2020) Tian Wang et al.   BIOMATERIALS

Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors

(2020) Hai-Shan Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron

(2020) Nina Seiwert et al.   Cell Death & Disease

5-(3,4-Difluorophenyl)−3-(6-methylpyridin-3-yl)−1,2,4-oxadiazole (DDO-7263), a Novel Nrf2 Activator Targeting Brain Tissue, Protects Against MPTP-induced Subacute Parkinson's Disease in Mice by Inhibiting the NLRP3 Inflammasome and Protects PC12 Cells Against Oxidative Stress

(2019) Li-Li Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

(2019) Jiabing Wang et al.   Acta Pharmaceutica Sinica B

Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

(2019) Kai Zhang et al.   NANO LETTERS

The global burden of stroke: persistent and disabling

(2019) Philip B Gorelick   LANCET NEUROLOGY

Effect of Edaravone on Neurological Symptoms in Real-World Patients With Acute Ischemic Stroke

(2019) Susumu Kobayashi et al.   STROKE

A Comparative Assessment Study of Known Small-Molecule Keap1−Nrf2 Protein–Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

(2019) Kim T. Tran et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

(2019) Tuo Yang et al.   EXPERIMENTAL NEUROLOGY

Design, synthesis, and evaluation of NDGA analogues as potential anti-ischemic stroke agents

(2018) Lili Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Structure-activity and structure-property relationships of novel Nrf2 activators with a 1,2,4-oxadiazole core and their therapeutic effects on acetaminophen (APAP)-induced acute liver injury

(2018) Li-Li Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear Factor (Erythroid-derived 2)-like 2 (NRF2) Inhibitors

(2018) Benjamin G. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pomalidomide Ameliorates H2O2-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects

(2018) Yan-Rou Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

(2017) Luisa Quinti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular similarity guided optimization of novel Nrf2 activators with 1,2,4-oxadiazole core

(2016) Li-Li Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury

(2015) Ying-Ying Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators

(2015) Atul D. Jain et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Evaluation of Triazole Derivatives That Induce Nrf2 Dependent Gene Products and Inhibit the Keap1–Nrf2 Protein–Protein Interaction

(2015) Hélène C. Bertrand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure–Activity Relationship Study

(2015) Li-Li Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY