A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator
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Title
A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator
Authors
Keywords
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Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume -, Issue -, Pages 114630
Publisher
Elsevier BV
Online
2022-08-11
DOI
10.1016/j.ejmech.2022.114630
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Note: Only part of the references are listed.- Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease
- (2022) Renren Bai et al. AGEING RESEARCH REVIEWS
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- (2021) Zhuang Zhang et al. ACS Chemical Neuroscience
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- (2021) Sung-Hwa Yoon et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- (2021) Zhipeng Zhang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2021) Shoaib Manzoor et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Alzheimer’s disease and its treatment by different approaches: A review
- (2021) Sukriti Srivastava et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and evaluation of multi-target-directed ligands with BACE-1 inhibitory and Nrf2 agonist activities as potential agents against Alzheimer’s disease
- (2021) Lailiang Qu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Benincasa hispida alleviates amyloid pathology by inhibition of Keap1/Nrf2-axis: Emphasis on oxidative and inflammatory stress involved in Alzheimer's disease model
- (2021) Deepthi Rapaka et al. NEUROPEPTIDES
- Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer’s disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies
- (2021) Tao Song et al. AGEING RESEARCH REVIEWS
- Discovery of 1,2,4-triazine dithiocarbamate derivatives as NEDDylation agonists to inhibit gastric cancers
- (2021) Jian Song et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- (2021) Dan Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Nrf2/Keap1/ARE signaling: Towards specific regulation
- (2021) Alexey V. Ulasov et al. LIFE SCIENCES
- Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges
- (2020) Pauline Zipfel et al. JOURNAL OF MEDICINAL CHEMISTRY
- Xanthohumol Analogues as Potent Nrf2 Activators against Oxidative Stress Mediated Damages of PC12 Cells
- (2019) Feifei Bai et al. ACS Chemical Neuroscience
- Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer’s disease
- (2019) Neng Jiang et al. BIOORGANIC CHEMISTRY
- Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation
- (2019) Aikaterini Pagoni et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent advances in α,β-unsaturated carbonyl compounds as mitochondrial toxins
- (2019) Mohammad Hossain et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
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- Novel multi-target compounds in the quest for new chemotherapies against Alzheimer’s disease: An experimental and theoretical study
- (2018) Alberto Martínez et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
- (2018) Masha G. Savelieff et al. CHEMICAL REVIEWS
- Tranilast treatment attenuates cerebral ischemia‐reperfusion injury in rats through the inhibition of inflammatory responses mediated by NF ‐ κB and PPAR s
- (2018) Yue Zhuo et al. CTS-Clinical and Translational Science
- Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer’s compounds: In vitro and in vivo biological evaluation and docking study
- (2018) Zahra Najafi et al. BIOORGANIC CHEMISTRY
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- (2017) Lhassane Ismaili et al. PROGRESS IN NEUROBIOLOGY
- The Antioxidant Additive Approach for Alzheimer’s Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators
- (2016) Mohamed Benchekroun et al. JOURNAL OF MEDICINAL CHEMISTRY
- World Alzheimer report 2014: Dementia and risk reduction
- (2015) Marc Wortmann Alzheimers & Dementia
- Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer’s disease
- (2015) Qiang Liu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells
- (2015) Juan Yao et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents
- (2015) Shoujiao Peng et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2015) Sara Darakhshan et al. PHARMACOLOGICAL RESEARCH
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- (2015) Gohar Mushtaq et al. SAUDI JOURNAL OF BIOLOGICAL SCIENCES
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- (2014) Kristina Clemons et al. SCIENCE & JUSTICE
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- (2013) Sun Young Park et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Revisiting the cholinergic hypothesis in the development of Alzheimer's disease
- (2011) Laura A. Craig et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
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