The 4-Hydroxynonenal–Protein Adducts and Their Biological Relevance: Are Some Proteins Preferred Targets?

Relationship between 4-Hydroxynonenal (4-HNE) as Systemic Biomarker of Lipid Peroxidation and Metabolomic Profiling of Patients with Prostate Cancer

(2023) Matea Nikolac Perkovic et al.   Biomolecules

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

(2022) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19

(2022) Neven Zarkovic et al.   Cells

Chemistry and Biochemistry Aspects of the 4-Hydroxy-2,3-trans-nonenal

(2022) Anna Bilska-Wilkosz et al.   Biomolecules

Erythrocytes Induce Vascular Dysfunction in COVID-19

(2022) Ali Mahdi et al.   JACC-Basic to Translational Science

Oxidative stress and regeneration

(2022) Morana Jaganjac et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress and Cancer Heterogeneity Orchestrate NRF2 Roles Relevant for Therapy Response

(2022) Koraljka Gall Trošelj et al.   MOLECULES

Heat Shock Proteins and HSF1 in Cancer

(2022) Anna M. Cyran et al.   Frontiers in Oncology

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

(2022) Xin Chen et al.   Nature Communications

Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction

(2022) Sudha Sharma et al.   Biomolecules

Sensitivity of Osteosarcoma Cells to Concentration-Dependent Bioactivities of Lipid Peroxidation Product 4-Hydroxynonenal Depend on Their Level of Differentiation

(2021) Suzana Borovic Sunjic et al.   Cells

Protective Effects of Cannabidiol on the Membrane Proteome of UVB-Irradiated Keratinocytes

(2021) Sinemyiz Atalay et al.   Antioxidants

Targeting prominin2 transcription to overcome ferroptosis resistance in cancer

(2021) Caitlin W Brown et al.   EMBO Molecular Medicine

Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols

(2021) Max Sauerland et al.   FREE RADICAL BIOLOGY AND MEDICINE

Preliminary Findings on the Association of the Lipid Peroxidation Product 4-Hydroxynonenal with the Lethal Outcome of Aggressive COVID-19

(2021) Neven Žarković et al.   Antioxidants

Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry

(2021) Afnan Saleh Al-Menhali et al.   Frontiers in Molecular Biosciences

Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications

(2021) Camilla Andersen et al.   BIOCHEMISTRY

Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress

(2021) Charlie Jr Lavilla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation in brain tumors

(2021) Morana Jaganjac et al.   NEUROCHEMISTRY INTERNATIONAL

Oxidative Stress in Autoimmune Diseases: An under dealt malice

(2020) Sheetal Ramani et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma

(2020) Yongfei Yang et al.   Nature Communications

4-Hydroxynonenal induces Cx46 hemichannel inhibition through its carbonylation

(2020) Mauricio A. Retamal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies

(2020) Morana Jaganjac et al.   Antioxidants

Histone Carbonylation Is a Redox-Regulated Epigenomic Mark That Accumulates with Obesity and Aging

(2020) Amy K. Hauck et al.   Antioxidants

Identification of 4-hydroxynonenal-modified proteins in human osteoarthritic chondrocytes

(2020) Timon Geib et al.   Journal of Proteomics

The proteomic profile of keratinocytes and lymphocytes in psoriatic patients

(2019) Agnieszka Gęgotek et al.   Proteomics Clinical Applications

Epitope mapping and characterization of 4-hydroxy-2-nonenal modified-human serum albumin using two different polyclonal antibodies

(2019) Isabel Campos-Pinto et al.   FREE RADICAL BIOLOGY AND MEDICINE

SLC27A5 deficiency activates NRF2/TXNRD1 pathway by increased lipid peroxidation in HCC

(2019) Qingzhu Gao et al.   CELL DEATH AND DIFFERENTIATION

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

(2019) Lidija Milkovic et al.   Cells

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

(2019) Morana Jaganjac et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

(2019) Himangshu Sonowal et al.   Oxidative Medicine and Cellular Longevity

Lipid peroxidation is involved in calcium dependent upregulation of mitochondrial metabolism in skeletal muscle

(2019) Afnan Saleh Al-Menhali et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Obesity-Induced Protein Carbonylation In Murine Adipose Tissue Regulates The DNA Binding Domain Of Nuclear Zinc-Finger Proteins

(2018) Amy K Hauck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic plasma profile of psoriatic patients

(2018) Agnieszka Gęgotek et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Quantitative Profiling of Protein Carbonylations in Ferroptosis by an Aniline-Derived Probe

(2018) Ying Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Oxidative damage in naturally aged mouse oocytes is exacerbated by dysregulation of proteasomal activity

(2018) Bettina P. Mihalas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

4-hydroxynonenal causes impairment of human subcutaneous adipogenesis and induction of adipocyte insulin resistance

(2017) Mohamed A. Elrayess et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxynonenal (HNE) modified proteins in metabolic diseases

(2017) José Pedro Castro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial control of apoptosis through modulation of cardiolipin oxidation in hepatocellular carcinoma: A novel link between oxidative stress and cancer

(2017) Huiqin Zhong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Contribution of the HNE-immunohistochemistry to modern pathological concepts of major human diseases

(2017) Kamelija Zarkovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress: Harms and Benefits for Human Health

(2017) Gabriele Pizzino et al.   Oxidative Medicine and Cellular Longevity

Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients

(2017) Morana Jaganjac et al.   Redox Biology

Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe

(2017) Ying Chen et al.   Redox Biology

Oxidative stress and antioxidants: Distress or eustress ?

(2016) Etsuo Niki   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression

(2016) Jeannie M. Camarillo et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins

(2016) Roshanak Aslebagh et al.   ELECTROPHORESIS

A method to produce fully characterized ubiquitin covalently modified by 4-hydroxy-nonenal, glyoxal, methylglyoxal, and malondialdehyde

(2016) Mara Colzani et al.   FREE RADICAL RESEARCH

Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer

(2016) Y Yang et al.   ONCOGENE

Identification of 4-hydroxynonenal protein targets in rat, mouse and human liver microsomes by two-dimensional liquid chromatography/tandem mass spectrometry

(2016) Makan Golizeh et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Label-Free Proteomics Assisted by Affinity Enrichment for Elucidating the Chemical Reactivity of the Liver Mitochondrial Proteome toward Adduction by the Lipid Electrophile 4-hydroxy-2-nonenal (HNE)

(2016) Shin-Cheng Tzeng et al.   Frontiers in Chemistry

Quantitative Chemoproteomics for Site-Specific Analysis of Protein Alkylation by 4-Hydroxy-2-Nonenal in Cells

(2015) Jing Yang et al.   ANALYTICAL CHEMISTRY

Revealing mechanisms of selective, concentration-dependent potentials of 4-hydroxy-2-nonenal to induce apoptosis in cancer cells through inactivation of membrane-associated catalase

(2015) Georg Bauer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of an unstable 4-hydroxynoneal modification on the 20S proteasome subunit α7 by recombinant antibody technology.

(2015) Jesper Just et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

(2015) L. Milkovic et al.   FREE RADICAL RESEARCH

Protein “amyloid-like” networks at the phospholipid membrane formed by 4-hydroxy-2-nonenal-modified mitochondrial creatine kinase

(2015) Ofelia Maniti et al.   MOLECULAR MEMBRANE BIOLOGY

Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

(2015) Eun Ji Jang et al.   PLoS One

Elastin aging and lipid oxidation products in human aorta

(2015) Kamelija Zarkovic et al.   Redox Biology

Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment

(2014) Y. Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function

(2014) James J. Galligan et al.   FREE RADICAL BIOLOGY AND MEDICINE

4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts

(2014) Pauline Larroque-Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response

(2014) Saba Parvez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alkylation Damage by Lipid Electrophiles Targets Functional Protein Systems

(2014) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

Demonstration of HNE-related Aldehyde Formation via Lipoxygenase-catalyzed Synthesis of a bis-Allylic Dihydroperoxide Intermediate

(2013) Jing Jin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

(2013) Mohammad Shoeb et al.   CURRENT MEDICINAL CHEMISTRY

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

(2013) C.T. Shearn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiological relevance of aldehydic protein modifications

(2013) Neven Zarkovic et al.   Journal of Proteomics

Temporally Controlled Targeting of 4-Hydroxynonenal to Specific Proteins in Living Cells

(2013) Xinqiang Fang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

Measurement of HNE-protein adducts in human plasma and serum by ELISA—Comparison of two primary antibodies

(2013) Daniela Weber et al.   Redox Biology

Lipid peroxidation triggers neurodegeneration: A redox proteomics view into the Alzheimer disease brain

(2012) Rukhsana Sultana et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

(2012) Rebecca L. Smathers et al.   PLoS One

Identification of 4-hydroxy-2-nonenal–histidine adducts that serve as ligands for human lectin-like oxidized LDL receptor-1

(2011) Miyuki Kumano-Kuramochi et al.   BIOCHEMICAL JOURNAL

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

Structural and Functional Changes in Human Insulin Induced by the Lipid Peroxidation Byproducts 4-Hydroxy-2-nonenal and 4-Hydroxy-2-hexenal

(2011) Nicolas J. Pillon et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Protein-Selective Capture to Analyze Electrophile Adduction of Hsp90 by 4-Hydroxynonenal

(2011) Rebecca E. Connor et al.   CHEMICAL RESEARCH IN TOXICOLOGY

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

(2011) Kristofer S. Fritz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A method for detection of 4-hydroxy-2-nonenal adducts in proteins

(2011) Chika Wakita et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling and cytotoxic functions of 4-hydroxyalkenals

(2010) Yael Riahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glutathione transferase A4-4 resists adduction by 4-hydroxynonenal

(2010) Laura M. Shireman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Site-Specific Protein Adducts of 4-Hydroxy-2(E)-Nonenal in Human THP-1 Monocytic Cells: Protein Carbonylation Is Diminished by Ascorbic Acid

(2010) Juan Chavez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Posttranslational modification and regulation of glutamate–cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

(2010) Donald S. Backos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

(2010) Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples

(2010) Nicolle Breusing et al.   FREE RADICAL RESEARCH

Advances in methods for the determination of biologically relevant lipid peroxidation products

(2010) Corinne M. Spickett et al.   FREE RADICAL RESEARCH

A fish oil-rich diet reduces vascular oxidative stress in apoE–/–mice

(2010) Kelly Casós et al.   FREE RADICAL RESEARCH

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal

(2009) Nobuto Arashiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential distribution of 4-hydroxynonenal adducts to sulfur and nitrogen residues in blood proteins as revealed using Raney nickel and gas chromatography–mass spectrometry

(2009) Jean-François Lesgards et al.   FREE RADICAL BIOLOGY AND MEDICINE

Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein

(2009) Chika Wakita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Azido-Biotin Reagent for Use in the Isolation of Protein Adducts of Lipid-derived Electrophiles by Streptavidin Catch and Photorelease

(2009) Hye-Young H. Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Low-Density Lipoprotein Has an Enormous Capacity To Bind (E)-4-Hydroxynon-2-enal (HNE): Detection and Characterization of Lysyl and Histidyl Adducts Containing Multiple Molecules of HNE

(2008) Suresh P. Annangudi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro and in Silico Characterization of Peroxiredoxin 6 Modified by 4-Hydroxynonenal and 4-Oxononenal

(2008) James R. Roede et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives

(2008) Andrew Vila et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal

(2008) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal

(2008) Richard M. LoPachin et al.   TOXICOLOGICAL SCIENCES