Kinetic assessment of Michael addition reactions of alpha, beta-unsaturated carbonyl compounds to amino acid and protein thiols

Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals

(2020) Jesse R. Poganik et al.   Frontiers in Aging Neuroscience

Structural insights into the multiple binding modes of Dimethyl Fumarate (DMF) and its analogs to the Kelch domain of Keap1

(2020) Sruthi Unni et al.   FEBS Journal

Application of the hard and soft, acids and bases (HSAB) theory as a method to predict cumulative neurotoxicity

(2020) Fjodor Melnikov et al.   NEUROTOXICOLOGY

Comparative analysis of dimethyl fumarate and fingolimod in relapsing–remitting multiple sclerosis

(2020) Johannes Lorscheider et al.   JOURNAL OF NEUROLOGY

Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?

(2020) Stephanie Kourakis et al.   Pharmaceuticals

The Role of Acrolein and NADPH Oxidase in the Granulocyte-Mediated Growth-Inhibition of Tumor Cells

(2019) Morana Jaganjac et al.   Cells

Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex

(2019) Balyn W. Zaro et al.   JOURNAL OF IMMUNOLOGY

Reaction of quinones with proteins: Kinetics of adduct formation, effects on enzymatic activity and protein structure, and potential reversibility of modifications

(2019) Nan Shu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Detection, identification, and quantification of oxidative protein modifications

(2019) Clare L. Hawkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dimethyl fumarate: targeting glycolysis to treat MS

(2018) Stefano Angiari et al.   CELL RESEARCH

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Functional consequences of piceatannol binding to glyceraldehyde-3-phosphate dehydrogenase

(2018) Joanna Gerszon et al.   PLoS One

The Immunometabolomic Interface Receptor Hydroxycarboxylic Acid Receptor 2 Mediates the Therapeutic Effects of Dimethyl Fumarate in Autoantibody-Induced Skin Inflammation

(2018) Melanie Wannick et al.   Frontiers in Immunology

Biomarkers of Chronic Acrolein Inhalation Exposure in Mice: Implications for Tobacco Product-Induced Toxicity

(2017) Daniel J. Conklin et al.   TOXICOLOGICAL SCIENCES

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders

(2016) Philip C. Burcham   CHEMICAL RESEARCH IN TOXICOLOGY

Quinone-induced protein modifications: Kinetic preference for reaction of 1,2-benzoquinones with thiol groups in proteins

(2016) Yuting Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

(2016) Paul A. Jackson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

Chemical proteomic map of dimethyl fumarate–sensitive cysteines in primary human T cells

(2016) Megan M. Blewett et al.   Science Signaling

The basics of thiols and cysteines in redox biology and chemistry

(2015) Leslie B. Poole   FREE RADICAL BIOLOGY AND MEDICINE

Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system

(2015) Yizhi Liu et al.   JOURNAL OF NEUROSURGERY

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Dimethyl Fumarate and Monoethyl Fumarate Exhibit Differential Effects on KEAP1, NRF2 Activation, and Glutathione Depletion In Vitro

(2015) Melanie S. Brennan et al.   PLoS One

Reevaluation of the rate constants for the reaction of hypochlorous acid (HOCl) with cysteine, methionine, and peptide derivatives using a new competition kinetic approach

(2014) Corin Storkey et al.   FREE RADICAL BIOLOGY AND MEDICINE

Rapid high-yieldN-acylation of aminothiols:N-acetylglutathione andN-acetylhomocysteine and their thiol pKavalues

(2013) Biao Shen et al.   JOURNAL OF PEPTIDE SCIENCE

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

(2013) L. Baird et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acrolein-induced activation of mitogen-activated protein kinase signaling is mediated by alkylation of thioredoxin reductase and thioredoxin 1

(2013) Matthew J. Randall et al.   Redox Biology

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions

(2011) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

(2010) M. McMahon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation

(2009) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantification of protein modification by oxidants

(2009) Clare L. Hawkins et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

(2008) Jan F. Stevens et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Synaptosomal Toxicity and Nucleophilic Targets of 4-Hydroxy-2-Nonenal

(2008) Richard M. LoPachin et al.   TOXICOLOGICAL SCIENCES