A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin

(2013) John Wong et al.   CANCER BIOLOGY & THERAPY

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

(2012) Jerry E. Chipuk et al.   CELL

An overview of the chemistry and biology of reactive aldehydes

(2012) Kristofer S. Fritz et al.   FREE RADICAL BIOLOGY AND MEDICINE

A comparative ‘bottom up’ proteomics strategy for the site-specific identification and quantification of protein modifications by electrophilic lipids

(2012) Bingnan Han et al.   Journal of Proteomics

Exploring Post-translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones

(2012) Tina Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

15-Deoxy-Δ12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling

(2011) Young-Joon Surh et al.   BIOCHEMICAL PHARMACOLOGY

Modification of Akt2 by 4-Hydroxynonenal Inhibits Insulin-Dependent Akt Signaling in HepG2 Cells

(2011) C. T. Shearn et al.   BIOCHEMISTRY

Exploring the Biology of Lipid Peroxidation-Derived Protein Carbonylation

(2011) Kristofer S. Fritz et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

(2011) Alexander Adibekian et al.   Nature Chemical Biology

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

(2011) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Analysis of Protein Modification and Cellular Responses Induced by Electrophile Stress

(2010) Aaron T. Jacobs et al.   ACCOUNTS OF CHEMICAL RESEARCH

Role of 4-hydroxy-trans-2-nonenal in cell functions

(2010) E. E. Dubinina et al.   BIOCHEMISTRY-MOSCOW

ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner

(2010) Jaw-Ji Yang et al.   CANCER SCIENCE

Chemical ‘omics’ approaches for understanding protein cysteine oxidation in biology

(2010) Stephen E Leonard et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemistry and biochemistry of lipid peroxidation products

(2010) F. Guéraud et al.   FREE RADICAL RESEARCH

Tyrosine Bioconjugation through Aqueous Ene-Type Reactions: A Click-Like Reaction for Tyrosine

(2010) Hitoshi Ban et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Molecular Mechanisms of 4-Hydroxy-2-nonenal and Acrolein Toxicity: Nucleophilic Targets and Adduct Formation

(2009) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Methods for imaging and detecting modification of proteins by reactive lipid species

(2009) Ashlee N. Higdon et al.   FREE RADICAL BIOLOGY AND MEDICINE

An Azido-Biotin Reagent for Use in the Isolation of Protein Adducts of Lipid-derived Electrophiles by Streptavidin Catch and Photorelease

(2009) Hye-Young H. Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Transduction of Redox Signaling by Electrophile-Protein Reactions

(2009) T. K. Rudolph et al.   Science Signaling

Identification of Protein Targets of 4-Hydroxynonenal Using Click Chemistry for ex Vivo Biotinylation of Azido and Alkynyl Derivatives

(2008) Andrew Vila et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Global Analysis of Protein Damage by the Lipid Electrophile 4-Hydroxy-2-nonenal

(2008) Simona G. Codreanu et al.   MOLECULAR & CELLULAR PROTEOMICS

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology