Oxidative stress and regeneration

The distribution of cellular turnover in the human body

(2021) Ron Sender et al.   NATURE MEDICINE

Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion

(2021) Brendan Puls et al.   Frontiers in Cell and Developmental Biology

Wnt/β-Catenin Signaling Promotes Differentiation of Ischemia-Activated Adult Neural Stem/Progenitor Cells to Neuronal Precursors

(2021) Jan Kriska et al.   Frontiers in Neuroscience

Sensitivity of Osteosarcoma Cells to Concentration-Dependent Bioactivities of Lipid Peroxidation Product 4-Hydroxynonenal Depend on Their Level of Differentiation

(2021) Suzana Borovic Sunjic et al.   Cells

The P2X7 Receptor in Microglial Cells Modulates the Endolysosomal Axis, Autophagy, and Phagocytosis

(2021) Keith E. Campagno et al.   Frontiers in Cellular Neuroscience

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

(2021) Min Woo Park et al.   Redox Biology

The nexus between redox state and intermediary metabolism

(2021) Anna Zoccarato et al.   FEBS Journal

Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing

(2021) Sujeong Yang et al.   MOLECULAR PSYCHIATRY

Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man

(2021) Sergey A. Sinenko et al.   Frontiers in Cell and Developmental Biology

Autocrine Effects of Brain Endothelial Cell-Produced Human Apolipoprotein E on Metabolism and Inflammation in vitro

(2021) Felecia M. Marottoli et al.   Frontiers in Cell and Developmental Biology

Association of Lipid Peroxidation Product 4-Hydroxynonenal with Post-Traumatic Stress Disorder

(2021) Matea Nikolac Perković et al.   Biomolecules

Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry

(2021) Afnan Saleh Al-Menhali et al.   Frontiers in Molecular Biosciences

Lipid peroxidation in brain tumors

(2021) Morana Jaganjac et al.   NEUROCHEMISTRY INTERNATIONAL

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

(2020) Yaxing Chen et al.   CELL PROLIFERATION

APOE in the normal brain

(2020) Sarah A. Flowers et al.   NEUROBIOLOGY OF DISEASE

RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury

(2020) Shalaka Mulherkar et al.   Cells

Reduced Sulfation Enhanced Oxytosis and Ferroptosis in Mouse Hippocampal HT22 Cells

(2020) Haruna Nagase et al.   Biomolecules

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive Oxygen Species Imaging in U937 Cells

(2020) Ankush Prasad et al.   Frontiers in Physiology

Induced pluripotent stem cell-derived neural progenitor cell transplantation promotes regeneration and functional recovery after post-traumatic stress disorder in rats

(2020) Qingzhen Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Canonical Wnt Pathway Maintains Blood-Brain Barrier Integrity upon Ischemic Stroke and Its Activation Ameliorates Tissue Plasminogen Activator Therapy

(2019) Noëmie Jean LeBlanc et al.   MOLECULAR NEUROBIOLOGY

MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells

(2019) Mehtab Khan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress

(2019) Tarun N. Bhatia et al.   Frontiers in Molecular Neuroscience

Redox Signaling via Lipid Peroxidation Regulates Retinal Progenitor Cell Differentiation

(2019) Shahad Albadri et al.   DEVELOPMENTAL CELL

Endothelial Targeted Strategies to Combat Oxidative Stress: Improving Outcomes in Traumatic Brain Injury

(2019) Evan M. Lutton et al.   Frontiers in Neurology

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

(2019) Lidija Milkovic et al.   Cells

MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway

(2019) Tingting Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases

(2019) Morana Jaganjac et al.   FREE RADICAL BIOLOGY AND MEDICINE

Moving beyond the glial scar for spinal cord repair

(2019) Elizabeth J. Bradbury et al.   Nature Communications

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Regulation of neuronal development and function by ROS

(2018) Matthew C. W. Oswald et al.   FEBS LETTERS

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

ALDH2 Protects Against Ischemic Stroke in Rats by Facilitating 4-HNE Clearance and AQP4 Down-Regulation

(2018) Yan Li et al.   NEUROCHEMICAL RESEARCH

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

(2018) Julian H. Birnbaum et al.   Stem Cell Research

SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury

(2018) Emma V. Jones et al.   Frontiers in Cellular Neuroscience

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress

(2018) Simon Gutbier et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Engulfing cells promote neuronal regeneration and remove neuronal debris through distinct biochemical functions of CED-1

(2018) Hui Chiu et al.   Nature Communications

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

(2018) Matthew CW Oswald et al.   eLife

4-hydroxynonenal-mediated signaling and aging

(2017) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cancer growth regulation by 4-hydroxynonenal

(2017) Ana Cipak Gasparovic et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Time courses of post-injury mitochondrial oxidative damage and respiratory dysfunction and neuronal cytoskeletal degradation in a rat model of focal traumatic brain injury

(2017) Rachel L. Hill et al.   NEUROCHEMISTRY INTERNATIONAL

RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury

(2017) Shalaka Mulherkar et al.   Scientific Reports

MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats

(2016) Sonu Singh et al.   ACS Chemical Neuroscience

Oxidative stress and antioxidants: Distress or eustress ?

(2016) Etsuo Niki   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biocompatibility of implantable materials: An oxidative stress viewpoint

(2016) Pierre-Alexis Mouthuy et al.   BIOMATERIALS

Manipulating Wnt signaling at different subcellular levels affects the fate of neonatal neural stem/progenitor cells

(2016) Jan Kriska et al.   BRAIN RESEARCH

Hydrogen peroxide (H 2 O 2 ) controls axon pathfinding during zebrafish development

(2016) Carole Gauron et al.   DEVELOPMENTAL BIOLOGY

Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes

(2016) Paul S. Baxter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pathophysiology of neutrophil-mediated extracellular redox reactions

(2016) Morana Jaganjac   Frontiers in Bioscience-Landmark

Dissecting the role of redox signaling in neuronal development

(2016) Daniel A. Bórquez et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention

(2016) Beatrice Vignoli et al.   NEURON

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

(2016) Geoffrey Burnstock   NEUROPHARMACOLOGY

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

(2016) Francisco J. Carvajal et al.   NEURAL PLASTICITY

On the role of 4-hydroxynonenal in health and disease

(2015) Miklós Csala et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

(2015) L. Milkovic et al.   FREE RADICAL RESEARCH

Foam cell-derived 4-hydroxynonenal induces endothelial cell senescence in a TXNIP-dependent manner

(2015) Yael Riahi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Characterization of traumatic brain injury in human brains reveals distinct cellular and molecular changes in contusion and pericontusion

(2015) Gangadharappa Harish et al.   JOURNAL OF NEUROCHEMISTRY

Functional differences between microglia and monocytes after ischemic stroke

(2015) Rodney M. Ritzel et al.   Journal of Neuroinflammation

Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study

(2015) Rita V. Krishnamurthi et al.   NEUROEPIDEMIOLOGY

Regulation of cytoskeletal dynamics by redox signaling and oxidative stress: implications for neuronal development and trafficking

(2015) Carlos Wilson et al.   Frontiers in Cellular Neuroscience

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Ion exchanger in the brain: Quantitative analysis of perineuronally fixed anionic binding sites suggests diffusion barriers with ion sorting properties

(2015) Markus Morawski et al.   Scientific Reports

Limb Ischemic Perconditioning Attenuates Blood-Brain Barrier Disruption by Inhibiting Activity of MMP-9 and Occludin Degradation after Focal Cerebral Ischemia

(2015) Changhong Ren et al.   Aging and Disease

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Elastin aging and lipid oxidation products in human aorta

(2015) Kamelija Zarkovic et al.   Redox Biology

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats

(2014) Fang-Ting Liu et al.   CNS Neuroscience & Therapeutics

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia–reperfusion injury

(2014) Toshinori Takagi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate

(2014) S. Miyata et al.   JOURNAL OF BIOCHEMISTRY

An overview of mechanisms of redox signaling

(2014) Henry Jay Forman et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Progesterone alters Nogo-A, GFAP and GAP-43 expression in a rat model of traumatic brain injury

(2014) FENG LIU et al.   Molecular Medicine Reports

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress

(2014) A Suttkus et al.   Cell Death & Disease

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

Axon growth inhibition by RhoA/ROCK in the central nervous system

(2014) Yuki Fujita et al.   Frontiers in Neuroscience

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia

(2013) Jiong Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance

(2013) S Dalleau et al.   CELL DEATH AND DIFFERENTIATION

ALDH2 protects against stroke by clearing 4-HNE

(2013) Jin-Min Guo et al.   CELL RESEARCH

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

(2013) Ziyuan Guo et al.   Cell Stem Cell

Nox4-Generated Superoxide Drives Angiotensin II-Induced Neural Stem Cell Proliferation

(2013) Elena Topchiy et al.   DEVELOPMENTAL NEUROSCIENCE

The role of astrocytes in mediating exogenous cell-based restorative therapy for stroke

(2013) Yi Li et al.   GLIA

Early Inhibition of MMP Activity in Ischemic Rat Brain Promotes Expression of Tight Junction Proteins and Angiogenesis During Recovery

(2013) Yi Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SPARC Regulates Microgliosis and Functional Recovery following Cortical Ischemia

(2013) S. M. Lloyd-Burton et al.   JOURNAL OF NEUROSCIENCE

Pathophysiological relevance of aldehydic protein modifications

(2013) Neven Zarkovic et al.   Journal of Proteomics

Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation

(2013) Sophia Bardehle et al.   NATURE NEUROSCIENCE

Astrocytic therapies for neuronal repair in stroke

(2013) Amy J. Gleichman et al.   NEUROSCIENCE LETTERS

Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

(2013) Yi-Bing Ouyang et al.   NEUROSCIENCE LETTERS

Moderate Hypoxia Followed by Reoxygenation Results in Blood-Brain Barrier Breakdown via Oxidative Stress-Dependent Tight-Junction Protein Disruption

(2013) Christoph M. Zehendner et al.   PLoS One

RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis

(2013) A Ferrés-Coy et al.   Translational Psychiatry

Timing of thrombolysis for acute ischemic stroke: “timing is everything” or “everyone is different”

(2012) James Grotta   Annals of the New York Academy of Sciences

d-Serine Regulates Proliferation and Neuronal Differentiation of Neural Stem Cells from Postnatal Mouse Forebrain

(2012) Xu Huang et al.   CNS Neuroscience & Therapeutics

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes

(2012) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis after Spinal Cord Injury—Beneficial and Detrimental Effects

(2012) Soheila Karimi-Abdolrezaee et al.   MOLECULAR NEUROBIOLOGY

A sulfated carbohydrate epitope inhibits axon regeneration after injury

(2012) J. M. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

(2012) Ying Huang et al.   Cell and Bioscience

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

(2011) Karsten Ruscher et al.   BRAIN

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis

(2011) Masahiro Okamoto et al.   FASEB JOURNAL

Nrf2 Expression by Neurons, Astroglia, and Microglia in the Cerebral Cortical Penumbra of Ischemic Rats

(2011) Jon Dang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

S-Nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats

(2011) Mushfiquddin Khan et al.   Journal of Neuroinflammation

Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke

(2011) Alessio Alfieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC

(2011) Hakan Kucukdereli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

(2011) P. Nix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke

(2011) Issei S. Shimada et al.   STROKE

Structural Remodeling of Fibrous Astrocytes after Axonal Injury

(2010) D. Sun et al.   JOURNAL OF NEUROSCIENCE

Nox2 redox signaling maintains essential cell populations in the brain

(2010) Bryan C Dickinson et al.   Nature Chemical Biology

Time-dependent contribution of non neuronal cells to BDNF production after ischemic stroke in rats

(2010) Yannick Béjot et al.   NEUROCHEMISTRY INTERNATIONAL

Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia ThroughAKT1and Mitochondrial Apoptotic Pathways

(2010) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Nonneuronal cells regulate synapse formation in the vestibular sensory epithelium via erbB-dependent BDNF expression

(2010) M. E. Gomez-Casati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of ferric ions on reactive oxygen species formation, cervical cancer cell lines growth and E6/E7 oncogene expression

(2010) Marija Poljak-Blazi et al.   TOXICOLOGY IN VITRO

Adult neural stem cells in the mammalian central nervous system

(2009) Dengke K Ma et al.   CELL RESEARCH

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Adaptation to oxidative stress induced by polyunsaturated fatty acids in yeast

(2008) Ana Cipak et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

(2008) H. Wang et al.   JOURNAL OF CELL SCIENCE

Thrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke

(2008) Jason Liauw et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Agrin Expression during Synaptogenesis Induced by Traumatic Brain Injury

(2008) M. Cristina Falo et al.   JOURNAL OF NEUROTRAUMA