The Role of Oxidative Stress in Vitiligo: An Update on Its Pathogenesis and Therapeutic Implications

The Role of Oxidative Stress in the Pathogenesis of Vitiligo: A Culprit for Melanocyte Death

(2022) Yijie Xuan et al.   Oxidative Medicine and Cellular Longevity

Update on the pathogenesis of vitiligo

(2022) Helena Zenedin Marchioro et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Reshaping endoplasmic reticulum quality control through the unfolded protein response

(2022) R. Luke Wiseman et al.   MOLECULAR CELL

The Hypopigmentation Mechanism of Tyrosinase Inhibitory Peptides Derived from Food Proteins: An Overview

(2022) Yuqiong Song et al.   MOLECULES

Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

(2022) Thobekile S. Leyane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy: Guardian of Skin Barrier

(2022) Hyun Jee Kim et al.   Biomedicines

Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzle

(2022) Daniela Kovacs et al.   Science Advances

Shining Light on Autophagy in Skin Pigmentation and Pigmentary Disorders

(2022) Daniela Kovacs et al.   Cells

Regenerative Medicine-Based Treatment for Vitiligo: An Overview

(2022) Barbara Bellei et al.   Biomedicines

A Concise Review on the Role of Endoplasmic Reticulum Stress in the Development of Autoimmunity in Vitiligo Pathogenesis

(2021) Shahnawaz D. Jadeja et al.   Frontiers in Immunology

Tumor Necrosis Factor-alpha affects melanocyte survival and melanin synthesis via multiple pathways in vitiligo

(2021) Mala Singh et al.   CYTOKINE

A protective role for autophagy in vitiligo

(2021) Emanuela Bastonini et al.   Cell Death & Disease

The Unfolded Protein Response: An Overview

(2021) Adam Read et al.   Biology-Basel

microRNAs in the Regulation of Melanogenesis

(2021) Yekatsiaryna Hushcha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenoside Rk1 protects human melanocytes from H2O2‑induced oxidative injury via regulation of the PI3K/AKT/Nrf2/HO‑1 pathway

(2021) Jian Xiong et al.   Molecular Medicine Reports

scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function

(2021) Kyle J. Gellatly et al.   Science Translational Medicine

The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress

(2021) Jun Tian et al.   Oxidative Medicine and Cellular Longevity

Prevalence of Vitiligo Among Adults in the United States

(2021) Kavita Gandhi et al.   JAMA Dermatology

Regulatory T Cells: Regulation of Identity and Function

(2021) Payal Grover et al.   Frontiers in Immunology

Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention

(2021) Wei-Ling Chang et al.   Frontiers in Cell and Developmental Biology

Clinical Significance of Serum Oxidative Stress Markers to Assess Disease Activity and Severity in Patients With Non-Segmental Vitiligo

(2021) Shuli Li et al.   Frontiers in Cell and Developmental Biology

Apigenin protects human melanocytes against oxidative damage by activation of the Nrf2 pathway

(2020) Baoxiang Zhang et al.   CELL STRESS & CHAPERONES

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo

(2020) Lifei Zhu et al.   Stem Cell Research & Therapy

Vitiligo: A Review

(2020) Christina Bergqvist et al.   DERMATOLOGY

6-Shogaol Protects Human Melanocytes against Oxidative Stress through Activation of the Nrf2-Antioxidant Response Element Signaling Pathway

(2020) Lingli Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo

(2020) Ming-Chen Sun et al.   International Journal of Nanomedicine

Molecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 Signaling

(2020) Wei Fang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Photoprotection and Skin Pigmentation: Melanin-Related Molecules and Some Other New Agents Obtained from Natural Sources

(2020) Francisco Solano   MOLECULES

The enigma and challenges of vitiligo pathophysiology and treatment

(2020) Zalfa A. Abdel-Malek et al.   Pigment Cell & Melanoma Research

Mechanisms of melanocyte death in vitiligo

(2020) Jianru Chen et al.   MEDICINAL RESEARCH REVIEWS

The unfolded protein and integrated stress response in melanoma and vitiligo

(2020) Prashiela Manga et al.   Pigment Cell & Melanoma Research

An update on Vitiligo pathogenesis

(2020) Julien Seneschal et al.   Pigment Cell & Melanoma Research

The fate of melanocyte: Mechanisms of cell death in vitiligo

(2020) Xiuyi Wu et al.   Pigment Cell & Melanoma Research

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Efficacy of Transplantation of Combination of Noncultured Dermal and Epidermal Cell Suspension vs Epidermal Cell Suspension Alone in Vitiligo

(2019) Vishal Thakur et al.   JAMA Dermatology

Attenuation of Myocardial ischemia reperfusion injury by Geniposide preconditioning in diabetic rats

(2019) Jia wang et al.   Current Research in Translational Medicine

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity

(2019) Yinghan Wang et al.   MEDICAL SCIENCE MONITOR

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

(2019) Meghri Katerji et al.   Oxidative Medicine and Cellular Longevity

Extracellular fraction of adipose tissue as an innovative regenerative approach for vitiligo treatment

(2019) B. Bellei et al.   EXPERIMENTAL DERMATOLOGY

Ginkgo biloba extract protects human melanocytes from H 2 O 2 ‐induced oxidative stress by activating Nrf2

(2019) Shaolong Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

(2019) Meri K. Tulic et al.   Nature Communications

ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells

(2019) Anastasiya V. Snezhkina et al.   Oxidative Medicine and Cellular Longevity

Fas‐FasL interaction in cytotoxic T cell‐mediated vitiligo: The role of lesional expression of tumor necrosis factor‐α and interferon‐γ in Fas‐mediated melanocyte apoptosis

(2019) Haruki Jimbo et al.   EXPERIMENTAL DERMATOLOGY

ROS and diseases: role in metabolism and energy supply

(2019) Shenshu Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

RNA-seq Reveals Dysregulation of Novel Melanocyte Genes upon Oxidative Stress: Implications in Vitiligo Pathogenesis

(2019) Konduru Seetharama Sastry et al.   Oxidative Medicine and Cellular Longevity

Effect of Dickkopf1 on the senescence of melanocytes: in vitro study

(2018) Seema Rani et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

(2018) Steven J. Forrester et al.   CIRCULATION RESEARCH

Geniposide prevents H2 O2 -induced oxidative damage in melanocytes by activating the PI3K-Akt signalling pathway

(2018) W. Lu et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Vitiligo Skin: Exploring the Dermal Compartment

(2018) Daniela Kovacs et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HSP70I Q435A -Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine

(2018) Steven W. Henning et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Role of ROS and Nutritional Antioxidants in Human Diseases

(2018) Zewen Liu et al.   Frontiers in Physiology

Vitamin D protects human melanocytes against oxidative damage by activation of Wnt/β-catenin signaling

(2018) Luyan Tang et al.   LABORATORY INVESTIGATION

Molecular and cellular basis of depigmentation in vitiligo patients

(2018) Véronique Delmas et al.   EXPERIMENTAL DERMATOLOGY

Baicalein protects human vitiligo melanocytes from oxidative stress through activation of NF-E2-related factor2 (Nrf2) signaling pathway

(2018) Jingjing Ma et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment with Modified Heat Shock Protein Repigments Vitiligo Lesions in Sinclair Swine

(2018) Michael L. Frisoli et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy

(2018) Silvia Mir-Palomo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Melanocyte-protective effect of afzelin is mediated by the Nrf2-ARE signalling pathway via GSK-3β inactivation

(2017) Eunsun Jung et al.   EXPERIMENTAL DERMATOLOGY

Oxidative stress drives CD8 + T-cell skin trafficking in patients with vitiligo through CXCL16 upregulation by activating the unfolded protein response in keratinocytes

(2017) Shuli Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes

(2017) Hiroshi Uchi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells

(2017) Magdalena Bartnik et al.   JOURNAL OF ETHNOPHARMACOLOGY

Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression

(2017) Ahmed F. Rezk et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Palladium and Platinum Nanoparticles Activate AHR and NRF2 in Human Keratinocytes—Implications in Vitiligo Therapy

(2017) Gaku Tsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Simvastatin Protects Human Melanocytes from H 2 O 2 -Induced Oxidative Stress by Activating Nrf2

(2017) Yuqian Chang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitiligo-like lesions occurring in patients receiving anti-programmed cell death–1 therapies are clinically and biologically distinct from vitiligo

(2017) Maiana Larsabal et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

An Isoxazole Chalcone Derivative Enhances Melanogenesis in B16 Melanoma Cells via the Akt/GSK3β/β-Catenin Signaling Pathways

(2017) Li Yin et al.   MOLECULES

CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study

(2017) Marwa Abdallah et al.   Pigment Cell & Melanoma Research

Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin

(2017) Maria Lucia Dell’Anna et al.   Scientific Reports

Genetic polymorphism of theNrf2promoter region is associated with vitiligo risk in Han Chinese populations

(2016) Pu Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aspirin induces Nrf2-mediated transcriptional activation of haem oxygenase-1 in protection of human melanocytes from H2O2-induced oxidative stress

(2016) Zhe Jian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?

(2016) Heng Xie et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Hyperoside protects human primary melanocytes against H2O2-induced oxidative damage

(2016) BIN YANG et al.   Molecular Medicine Reports

ROS and ROS-Mediated Cellular Signaling

(2016) Jixiang Zhang et al.   Oxidative Medicine and Cellular Longevity

Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis

(2016) Sikarin Upala et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Photoprotectionversusphotodamage: updating an old but still unsolved controversy about melanin

(2016) F Solano   POLYMER INTERNATIONAL

Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis

(2016) Bi-huan Xiao et al.   Biomed Research International

Regulatory T cells in vitiligo: Implications for pathogenesis and therapeutics

(2015) Mitesh Dwivedi et al.   AUTOIMMUNITY REVIEWS

Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo

(2015) Roselyne Y. Wagner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Maintenance Therapy of Adult Vitiligo with 0.1% Tacrolimus Ointment: A Randomized, Double Blind, Placebo–Controlled Study

(2015) Marine Cavalié et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitiligo

(2015) Khaled Ezzedine et al.   LANCET

Polymorphisms in Toll-like receptor genes are associated with vitiligo

(2015) Tanel Traks et al.   Frontiers in Genetics

Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling

(2014) Manash K. Paul et al.   Cell Stem Cell

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

(2014) Fabiola Osorio et al.   NATURE IMMUNOLOGY

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling

(2014) Jung-Min Shin et al.   PLoS One

A central role for inducible heat-shock protein 70 in autoimmune vitiligo

(2013) Jeffrey A. Mosenson et al.   EXPERIMENTAL DERMATOLOGY

Vitiligo: interplay between oxidative stress and immune system

(2013) Naresh C. Laddha et al.   EXPERIMENTAL DERMATOLOGY

Involvement of superoxide dismutase isoenzymes and their genetic variants in progression of and higher susceptibility to vitiligo

(2013) Naresh C. Laddha et al.   FREE RADICAL BIOLOGY AND MEDICINE

Involvement of Interferon-Gamma Genetic Variants and Intercellular Adhesion Molecule-1 in Onset and Progression of Generalized Vitiligo

(2013) Mitesh Dwivedi et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Oxidative Stress–Induced Calreticulin Expression and Translocation: New Insights into the Destruction of Melanocytes

(2013) Yajun Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress

(2013) Jeffrey A. Mosenson et al.   Pigment Cell & Melanoma Research

Tumor Necrosis Factor B (TNFB) Genetic Variants and Its Increased Expression Are Associated with Vitiligo Susceptibility

(2013) Naresh C. Laddha et al.   PLoS One

Role of Keratinocytes in the Development of Vitiligo

(2012) Ai-Young Lee   Annals of Dermatology

Altered levels of LXR-α: crucial implications in the pathogenesis of vitiligo

(2012) Ravinder Kumar et al.   EXPERIMENTAL DERMATOLOGY

Vitiligo-Inducing Phenols Activate the Unfolded Protein Response in Melanocytes Resulting in Upregulation of IL6 and IL8

(2012) Siavash Toosi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Innate and adaptive immune responses to cell death

(2011) Kenneth L. Rock et al.   IMMUNOLOGICAL REVIEWS

HSP70i is a critical component of the immune response leading to vitiligo

(2011) Jeffrey A. Mosenson et al.   Pigment Cell & Melanoma Research

Vitiligo, reactive oxygen species and T-cells

(2010) Steven J. Glassman   CLINICAL SCIENCE

Reduced Aquaporin3 Expression and Survival of Keratinocytes in the Depigmented Epidermis of Vitiligo

(2010) Nan-Hyung Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional Upregulation of Nrf2-Dependent Phase II Detoxification Genes in the Involved Epidermis of Vitiligo Vulgaris

(2010) Vivek T. Natarajan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin

(2009) GRaghu Rama Rao et al.   Indian Journal of Dermatology Venereology & Leprology

Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo

(2009) Ines Dammak et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

(2009) Jasper G. van den Boorn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HSP70i Accelerates Depigmentation in a Mouse Model of Autoimmune Vitiligo

(2008) Cecele J. Denman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A double-blind, randomized trial of 0.05% betamethasone vs. topical catalase/dismutase superoxide in vitiligo

(2008) G Sanclemente et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Methionine Sulfoxide Reductases A and B Are Deactivated by Hydrogen Peroxide (H2O2) in the Epidermis of Patients with Vitiligo

(2007) Karin U. Schallreuter et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY