An update on Vitiligo pathogenesis

ATP-P2X7–Induced Inflammasome Activation Contributes to Melanocyte Death and CD8+ T-Cell Trafficking to the Skin in Vitiligo

(2020) Yuri Ahn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ruxolitinib cream for treatment of vitiligo: a randomised, controlled, phase 2 trial

(2020) David Rosmarin et al.   LANCET

First step in a new era for treatment of patients with vitiligo

(2020) Thierry Passeron   LANCET

Type-1 cytokines regulate matrix metalloprotease-9 production and E-cadherin disruption to promote melanocyte loss in vitiligo

(2020) Nesrine Boukhedouni et al.   JCI Insight

Vitiligo, From Physiopathology to Emerging Treatments: A Review

(2020) Laure Migayron et al.   Dermatology and Therapy

Perspectives of New Advances in the Pathogenesis of Vitiligo: From Oxidative Stress to Autoimmunity

(2019) Yinghan Wang et al.   MEDICAL SCIENCE MONITOR

Oxidative stress-induced IL-15 transtrans-presentation in keratinocytes contributes to CD8+ T cells activation via JAK-STAT pathway in vitiligo

(2019) Xuguang Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo

(2019) Tingting Cui et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

IL‐17A is not a treatment target in progressive vitiligo

(2019) Reinhart Speeckaert et al.   Pigment Cell & Melanoma Research

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo

(2019) Meri K. Tulic et al.   Nature Communications

miR-9 regulates melanocytes adhesion and migration during vitiligo repigmentation induced by UVB treatment

(2019) Mengyun Su et al.   EXPERIMENTAL CELL RESEARCH

Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo

(2019) Shuli Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders

(2019) Barbara Bellei et al.   AGEING RESEARCH REVIEWS

NKG2D Defines a Subset of Skin Effector Memory CD8 T Cells with Proinflammatory Functions in Vitiligo

(2019) Clément Jacquemin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Metazoan MicroRNAs

(2018) David P. Bartel   CELL

Vitiligo Skin: Exploring the Dermal Compartment

(2018) Daniela Kovacs et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3

(2018) Katia Boniface et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

(2018) Jillian M. Richmond et al.   Science Translational Medicine

Covalent Strategies for Targeting Messenger and Non-Coding RNAs: An Updated Review on siRNA, miRNA and antimiR Conjugates

(2018) Santiago Grijalvo et al.   Genes

TRPM2 mediates mitochondria-dependent apoptosis of melanocytes under oxidative stress

(2018) Pan Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular and cellular basis of depigmentation in vitiligo patients

(2018) Véronique Delmas et al.   EXPERIMENTAL DERMATOLOGY

Involvement of non melanocytic skin cells in vitiligo

(2018) Emanuela Bastonini et al.   EXPERIMENTAL DERMATOLOGY

CD49a Expression Defines Tissue-Resident CD8 + T Cells Poised for Cytotoxic Function in Human Skin

(2017) Stanley Cheuk et al.   IMMUNITY

Precise role of dermal fibroblasts on melanocyte pigmentation

(2017) Yinjuan Wang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo

(2017) Anupama Sahoo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease

(2017) Jillian M. Richmond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CXCR3 Depleting Antibodies Prevent and Reverse Vitiligo in Mice

(2017) Jillian M. Richmond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism

(2017) Youdong Pan et al.   NATURE

CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study

(2017) Marwa Abdallah et al.   Pigment Cell & Melanoma Research

Wnt/β-catenin signaling pathway activates melanocyte stem cells in vitro and in vivo

(2016) Haiying Guo et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects

(2016) Parul Ganju et al.   Scientific Reports

Oxidative stress-induced overexpression of miR-25: the mechanism underlying the degeneration of melanocytes in vitiligo

(2015) Q Shi et al.   CELL DEATH AND DIFFERENTIATION

T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate

(2015) Laura K. Mackay et al.   IMMUNITY

Cellular stress and innate inflammation in organ-specific autoimmunity: lessons learned from vitiligo

(2015) John E. Harris   IMMUNOLOGICAL REVIEWS

Transcriptional Analysis of Vitiligo Skin Reveals the Alteration of WNT Pathway: A Promising Target for Repigmenting Vitiligo Patients

(2015) Claire Regazzetti et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Resident memory T cells in human health and disease

(2015) R. A. Clark   Science Translational Medicine

MicroRNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo

(2014) M.S. Mansuri et al.   BRITISH JOURNAL OF DERMATOLOGY

Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo

(2013) Lechun Lu et al.   GENE

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress

(2013) Jeffrey A. Mosenson et al.   Pigment Cell & Melanoma Research

Vitiligo: A Possible Model of Degenerative Diseases

(2013) Barbara Bellei et al.   PLoS One

Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo

(2013) J. A. Mosenson et al.   Science Translational Medicine

The Role of Endoplasmic Reticulum Stress in Autoimmune-Mediated Beta-Cell Destruction in Type 1 Diabetes

(2012) Jixin Zhong et al.   Experimental Diabetes Research

A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-γ for Autoreactive CD8+ T-Cell Accumulation in the Skin

(2012) John E. Harris et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MicroRNA: Biogenesis, Function and Role in Cancer

(2010) Leigh-Ann MacFarlane et al.   CURRENT GENOMICS

Membrane lipid defects are responsible for the generation of reactive oxygen species in peripheral blood mononuclear cells from vitiligo patients

(2010) Maria Lucia Dell'Anna et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage

(2009) Mohamed M. A. E. L. Salem et al.   FASEB JOURNAL

Ultrastructural and functional alterations of mitochondria in perilesional vitiligo skin

(2009) Francesca Prignano et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Dendritic Cell-Induced Memory T Cell Activation in Nonlymphoid Tissues

(2008) L. M. Wakim et al.   SCIENCE