scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function

Vitiligo: Mechanisms of Pathogenesis and Treatment

(2020) Michael L. Frisoli et al.   Annual Review of Immunology

Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune‐suppressive genes in regulatory T cells of generalized vitiligo patients

(2020) Prashant S. Giri et al.   Pigment Cell & Melanoma Research

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell-type-specific immune regulation in atopic dermatitis

(2020) Thomas B. Rojahn et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Type 1 Treg cells promote the generation of CD8+ tissue-resident memory T cells

(2020) Cristina Ferreira et al.   NATURE IMMUNOLOGY

Decreased suppression of CD8 + and CD4 + T cells by peripheral regulatory T cells in generalized vitiligo due to reduced NFATC1 and FOXP3 proteins

(2020) Prashant S. Giri et al.   EXPERIMENTAL DERMATOLOGY

Integrated transcriptomic and proteomic analysis of human eccrine sweat glands identifies missing and novel proteins

(2019) Chan Hyun Na et al.   MOLECULAR & CELLULAR PROTEOMICS

Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

(2018) Christina Philippeos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

(2018) Jihwan Park et al.   SCIENCE

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

(2018) Jillian M. Richmond et al.   Science Translational Medicine

Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution

(2018) Jeffrey B. Cheng et al.   Cell Reports

Vitiligo: Mechanistic insights lead to novel treatments

(2017) Michael L. Frisoli et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Keratinocyte-Derived Chemokines Orchestrate T-Cell Positioning in the Epidermis during Vitiligo and May Serve as Biomarkers of Disease

(2017) Jillian M. Richmond et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Current and emerging treatments for vitiligo

(2017) Michelle Rodrigues et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity

(2017) James P. Strassner et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

CCR8+FOXp3+Tregcells as master drivers of immune regulation

(2017) Yiftah Barsheshet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo

(2016) X. X. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Single-cell barcoding and sequencing using droplet microfluidics

(2016) Rapolas Zilionis et al.   Nature Protocols

Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

(2016) Nicholas Collins et al.   Nature Communications

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

(2016) Simon Joost et al.   Cell Systems

Alteration in regulatory T cells and programmed cell death 1-expressing regulatory T cells in active generalized vitiligo and their clinical correlation

(2015) M.K. Tembhre et al.   BRITISH JOURNAL OF DERMATOLOGY

Cellular stress and innate inflammation in organ-specific autoimmunity: lessons learned from vitiligo

(2015) John E. Harris   IMMUNOLOGICAL REVIEWS

Confetti-like depigmentation: A potential sign of rapidly progressing vitiligo

(2015) Juan Jesús Sosa et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

Assessment of tissue FoxP3+, CD4+and CD8+T-cells in active and stable nonsegmental vitiligo

(2014) Marwa Abdallah et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Detection of self-reactive CD8+T cells with an anergic phenotype in healthy individuals

(2014) Yuka Maeda et al.   SCIENCE

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

(2014) M. Rashighi et al.   Science Translational Medicine

Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses

(2013) Sarah Terras et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo

(2013) Shilpak Chatterjee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Decreased regulatory T-cells and CD4+/CD8+ratio correlate with disease onset and progression in patients with generalized vitiligo

(2013) Mitesh Dwivedi et al.   Pigment Cell & Melanoma Research

Mutant HSP70 Reverses Autoimmune Depigmentation in Vitiligo

(2013) J. A. Mosenson et al.   Science Translational Medicine

An integrative computational systems biology approach identifies differentially regulated dynamic transcriptome signatures which drive the initiation of human T helper cell differentiation

(2012) Tarmo Äijö et al.   BMC GENOMICS

Tumor-Derived Chemokine CCL5 Enhances TGF- -Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells

(2012) L.-Y. Chang et al.   CANCER RESEARCH

IFN-  Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease

(2012) C. Koenecke et al.   JOURNAL OF IMMUNOLOGY

A Mouse Model of Vitiligo with Focused Epidermal Depigmentation Requires IFN-γ for Autoreactive CD8+ T-Cell Accumulation in the Skin

(2012) John E. Harris et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Global Activation of CD8+ Cytotoxic T Lymphocytes Correlates with an Impairment in Regulatory T Cells in Patients with Generalized Vitiligo

(2012) Yang Lili et al.   PLoS One

Differentiation and function of Foxp3+ effector regulatory T cells

(2012) Erika Cretney et al.   TRENDS IN IMMUNOLOGY

Interleukin-12 Converts Foxp3+ Regulatory T Cells to Interferon–γ-Producing Foxp3+ T Cells That Inhibit Colitis

(2011) Ting Feng et al.   GASTROENTEROLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo

(2011) M. Ben Ahmed et al.   Pigment Cell & Melanoma Research

CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

(2010) Marcin Dobaczewski et al.   AMERICAN JOURNAL OF PATHOLOGY

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance

(2010) Emi K. Nishimura et al.   Cell Stem Cell

Interleukin-26: An IL-10-related cytokine produced by Th17 cells

(2010) Raymond P. Donnelly et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CD8 T Cells Activated in Distinct Lymphoid Organs Differentially Express Adhesion Proteins and Coexpress Multiple Chemokine Receptors

(2010) A. R. Ferguson et al.   JOURNAL OF IMMUNOLOGY

Mechanisms of Spatial and Temporal Development of Autoimmune Vitiligo in Tyrosinase-Specific TCR Transgenic Mice

(2010) Randal K. Gregg et al.   JOURNAL OF IMMUNOLOGY

Reduced skin homing by functional Treg in vitiligo

(2010) Jared Klarquist et al.   Pigment Cell & Melanoma Research

A scaling normalization method for differential expression analysis of RNA-seq data

(2010) Mark D Robinson et al.   GENOME BIOLOGY

Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

(2009) Jasper G. van den Boorn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

(2009) Markus Feuerer et al.   NATURE IMMUNOLOGY

Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells

(2008) C. Figueiredo et al.   BLOOD