Article
Oncology
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun
Summary: This study revealed that CXCR6 is exclusively expressed on intratumoral CD8(+) T cells, which are more immunocompetent and possess stronger antitumor activity. Additionally, CXCR6 may serve as a biomarker for tumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Haoxian Gou, Shenglu Liu, Linxin Liu, Ming Luo, Shu Qin, Kai He, Xiaoli Yang
Summary: Hepatocellular carcinoma (HCC) is a common and deadly liver malignancy. This study confirms that liver sinusoidal endothelial cells (LSEC) secrete CXCL16, which promotes the accumulation of CXCR6(+) NKT cells in the liver and has potent antitumor effects. High expression of CXCL16 is associated with activated NKT cells and increased interferon-gamma (IFN-gamma) production. The combination of a farnesoid X receptor agonist and a takeda G protein coupled receptor 5 antagonist exhibits significant tumor suppressive effects in an orthotopic liver tumor model, possibly through the CXCL16/CXCR6 axis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Maurizio Zanetti, Su Xian, Magalie Dosset, Hannah Carter
Summary: The tumor-immune interface is crucial for understanding immune surveillance and cancer immunotherapy. Recent research has shown the unfolded protein response (UPR) plays a role in modulating tumor cell fitness, drug resistance, and immune cell function. Additionally, aneuploidy has been linked to local immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jiajing Lu, Xiaoyuan Zhong, Chunyuan Guo, Li Tang, Ning Yu, Chen Peng, Yangfeng Ding, Xunxia Bao, Jing Zhou, Yuling Shi
Summary: Pustular psoriasis (PP) is a chronic inflammatory disease with various complications. This study found that TLR7 induces inflammatory response in PP, and CXCL16 and CXCR6 are overexpressed in PP lesions. It is unclear whether TLR7 and CXCL16 can be targeted in PP therapy.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Soumaya Karaki, Charlotte Blanc, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Estelle Dransart, Marie Anson, Corinne Tanchot, Lea Paolini, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Nadine Benhamouda, Cecile Badoual, Diane Damotte, Emmanuel Donnadieu, Sebastian Kobold, Fathia Mami-Chouaib, Rachel Golub, Ludger Johannes, Eric Tartour
Summary: This study demonstrates the in vivo role of the CXCR6-CXCL16 axis in the migration of CD8(+) resident memory T cells in lung mucosa after intranasal vaccination, leading to tumor growth control. Intranasal vaccination induces higher and more sustained concentrations of CXCL16, compared with other chemokines, showing superior efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Kushal Kandhari, Rama Kant, Neha Mishra, Chapla Agarwal, Rajesh Agarwal
Summary: Phenylarsine oxide (PAO), a highly toxic chemical warfare agent, can cause significant corneal injury through oxidative stress and cell death. This study used human corneal epithelial cells and an ex vivo rabbit corneal culture model to investigate the effects of PAO. It was found that PAO induced oxidative stress and cell death in corneal cells, leading to corneal injury. However, the toxicity of PAO was reversed by the antioxidant NAC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rosanna Culurciello, Andrea Bosso, Romualdo Troisi, Valentina Barrella, Ilaria Di Nardo, Margherita Borriello, Rosa Gaglione, Valeria Pistorio, Serena Aceto, Valeria Cafaro, Eugenio Notomista, Filomena Sica, Angela Arciello, Elio Pizzo
Summary: The study found that human angiogenin (ANG) can change its subcellular localization under different cellular stresses and regulate cellular homeostasis in HaCaT cells. This research provides new insights into the potential functions of ANG in the stress response of human skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Andrea M. Amitrano, Brandon J. Berry, Kihong Lim, Kyun-Do Kim, Richard E. Waugh, Andrew P. Wojtovich, Minsoo Kim
Summary: Cancer immunotherapy is more effective against hematological malignancies than solid tumors due to metabolic challenges in the tumor microenvironment. Mitochondria play a key role in CD8(+) T cell activation and effector function. Enhanced mitochondrial function is associated with improved T cell migration and effector function, highlighting the importance of mitochondrial metabolism in T cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Olga A. Smirnova, Olga N. Ivanova, Furkat Mukhtarov, Vladimir T. Valuev-Elliston, Artemy P. Fedulov, Petr M. Rubtsov, Natalia F. Zakirova, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov
Summary: Hepatitis delta virus (HDV) enhances oxidative and ER stress induced by hepatitis B virus (HBV), aggravating HBV-associated pathologies.
Review
Biochemistry & Molecular Biology
Magdalena Gebert, Jakub Slawski, Leszek Kalinowski, James F. Collawn, Rafal Bartoszewski
Summary: Efficient brain function requires a significant amount of oxygen intake, which can lead to oxidative stress and neurodegenerative diseases. The regulation of oxygen homeostasis and redox balance in the brain is mediated by stress response pathways, including the unfolded protein response (UPR). Understanding the opposing roles of UPR signaling pathways could provide insights for preventing cognitive decline and treating neurodegenerative diseases.
Article
Chemistry, Multidisciplinary
Philipp Schineis, Zuzanna K. Kotkowska, Sarah Vogel-Kindgen, Mona C. Friess, Martine Theisen, David Schwyter, Lucy Hausammann, Saurav Subedi, Eleni M. Varypataki, Ying Waeckerle-Men, Isabel Kolm, Thomas M. Kuendig, Anders Hogset, Bruno Gander, Cornelia Halin, Pal Johansen
Summary: Antigen cross-presentation to cytotoxic CD8+ T cells is crucial for anti-tumor and anti-viral immune responses. Co-encapsulation of photosensitizers and antigens into microspheres with subsequent photochemical internalization has emerged as a promising strategy. In vivo, dendritic cells take up the microspheres in peripheral tissues and migrate to tissue-draining lymph nodes for CD8+ T cell priming.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Environmental Sciences
Haihua Huo, Shuzhou Wang, Yuman Bai, Jianzhao Liao, Xinrun Li, Hui Zhang, Qingyue Han, Lianmei Hu, Jiaqiang Pan, Ying Li, Zhaoxin Tang, Jianying Guo
Summary: This study aimed to investigate the toxicity of copper in pig fundic glands. Results showed that excessive copper intake caused vacuolar degeneration, oxidative stress, and unfolded protein response. The study suggested that excessive copper absorption in fundic glands may be related to stimulating UPRmt, oxidative stress, and NRF2-mediated antioxidant defense.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Multidisciplinary Sciences
Ying Tang, Lei Liu, Ruyan Jie, Yizhong Tang, Xiaotong Zhao, Murong Xu, Mingwei Chen
Summary: This study investigated the effect of negative pressure wound therapy (NPWT) on the expression level of peroxiredoxin-2 (PRDX2) in patients with diabetic foot ulcer (DFU), and explored the association between PRDX2 expression and the treatment outcome. The results showed that NPWT could increase the expression of PRDX2 and promote wound healing.
SCIENTIFIC REPORTS
(2023)
Article
Environmental Sciences
Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan
Summary: This study demonstrates that Puerarin can alleviate the pathological damage caused by cadmium in rat cerebral cortex and reduce neurocyte viability. Puerarin reduces oxidative stress induced by cadmium by enhancing antioxidant defense, reducing ROS accumulation, and inhibiting the activation of the Nrf2 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Oncology
Ravikumar Muthuswamy, A. J. Robert McGray, Sebastiano Battaglia, Wenjun He, Anthony Miliotto, Cheryl Eppolito, Junko Matsuzaki, Tsuji Takemasa, Richard Koya, Thinle Chodon, Brian D. Lichty, Protul Shrikant, Kunle Odunsi
Summary: Resident memory CD8 T cells, characterized by their ability to reside in peripheral tissues, play a crucial role in adaptive sentinel activity and amplifying immune responses. The study focused on the chemotactic mechanisms governing the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment. Results indicated that CXCR6 is a key marker for resident memory tumor-specific CD8 T cells, with its deficiency resulting in reduced retention in tumor tissues and poor control of ovarian cancer. Further research is needed to explore the potential of utilizing CXCR6 to enhance resident memory responses in cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Letter
Infectious Diseases
Xiao Zhang, Guannan Zhu, Jinyuan Ma, Gang Wang
SURGICAL INFECTIONS
(2020)
Article
Dermatology
L. Yang, T. Zhang, C. Zhang, C. Xiao, X. Bai, G. Wang
Summary: This study reveals the essential role of Trim21 in mediating keratinocyte inflammation in psoriasis by ubiquitinating p65 and activating the NF-kappa B pathway. Targeting Trim21 may present a promising approach for psoriasis treatment.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Lin Gao, Li Wang, Kai Li, Qiang Tan, Erle Dang, Meiheng Lu, Yan Li, Wenbin Tan, Gang Wang
Summary: This study demonstrated that triple therapy is effective for the treatment of acne and should be further evaluated and investigated.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
Man Jiang, Hui Fang, Erle Dang, Jieyu Zhang, Pei Qiao, Chen Yu, Angang Yang, Gang Wang
Summary: Psoriatic keratinocytes transfer miR-381-3p to CD4(+)T cells through small extracellular vesicles (sEVs), inducing Th1 and Th17 polarization and promoting psoriasis development.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Cell Biology
Luting Yang, Gang Wang, Haibin Xia
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Dermatology
Jiaoling Chen, Zhenlai Zhu, Qingyang Li, Yiting Lin, Erle Dang, Hua Meng, Nanxi Sha, Hua Bai, Gang Wang, Shujie An, Shuai Shao
Summary: Neutrophil infiltration and papillary vessel dilation are characteristic features of the initiation phase of psoriatic lesions. Our study found that neutrophils activate cutaneous vascular endothelial cells, leading to vascular remodeling, vasodilation, and enhanced vascular permeability both in vivo and in vitro. Furthermore, MMP-9 secreted by psoriatic neutrophils activates vascular endothelial cells and enhances CD4(+) T-cell transmigration, facilitating the development of psoriatic lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Migara Kavishka Jayasinghe, Melissa Tan, Boya Peng, Yuqi Yang, Gautam Sethi, Marco Pirisinu, Minh T. N. Le
Summary: EVs, as bio-derived drug delivery vectors, provide a breakthrough in cancer therapy due to their natural origin and role in intercellular communication. Engineered EVs, with surface functionalization and drug encapsulation, can enhance drug loading, stealth properties, and tumor targeting capabilities.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Cell Biology
Tin Chanh Pham, Migara Kavishka Jayasinghe, Thach Tuan Pham, Yuqi Yang, Likun Wei, Waqas Muhammad Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung T. H. Nguyen, Dennis Kappei, Xuan-Hung Nguyen, William C. Cho, Jiahai Shi, Minh T. N. Le
Summary: The study presents a novel method for covalently conjugating EVs with targeting moieties using protein ligases, enabling specific delivery of therapeutic payloads to target cells without the need for genetic and chemical modifications. This approach shows promise for enhancing drug efficacy in cancer therapy by targeting specific receptors on cancer cells.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Dermatology
Bowei Li, Xiuli Yi, Tongtian Zhuang, Shaolong Zhang, Shuli Li, Yuqi Yang, Tingting Cui, Jiaxi Chen, Yuqian Chang, Tianwen Gao, Chunying Li, Ling Liu
Summary: This study found evidence of necroptosis in melanocytes from vitiligo perilesional skin, and oxidative stress was shown to trigger melanocyte death. The RIP1 signaling pathway plays a crucial role in this process.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Tingting Cui, Yinghan Wang, Pu Song, Xiuli Yi, Jiaxi Chen, Yuqi Yang, Huina Wang, Pan Kang, Sen Guo, Ling Liu, Kai Li, Zhe Jian, Shuli Li, Chunying Li
Summary: This study found that autophagy plays a protective role in oxidative stress-induced melanocyte death, and dysregulated autophagy increases the sensitivity of melanocytes to oxidative damage. HSF1 was identified as the key transcription factor for autophagosome formation, and deficiency of HSF1 led to melanocyte apoptosis under oxidative stress. Overexpression of HSF1 could ameliorate oxidative stress-induced melanocyte death through upregulation of ATG5 and ATG12. These findings suggest that targeting the HSF1-ATG5/12 axis could be a potential therapeutic strategy for vitiligo treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Weinan Guo, Zhenjie Wu, Jianru Chen, Sen Guo, Weiming You, Sijia Wang, Jinyuan Ma, Huina Wang, Xiangxu Wang, Hao Wang, Jingjing Ma, Yuqi Yang, Yangzi Tian, Qiong Shi, Tianwen Gao, Xiuli Yi, Chunying Li
Summary: The upregulation of miR-21-3p contributes to IFN-gamma-driven ferroptosis and synergizes with anti-PD-1 antibody. Nanoparticle delivery of miR-21-3p is a promising therapeutic approach to increase immunotherapy efficacy without obvious systemic side effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Lin Gao, Wei Wen, Yuanli Wang, Zhaoyang Li, Erle Dang, Lei Yu, Chenxi Zhou, Meiheng Lu, Gang Wang
Summary: Fractional CO2 vaginal laser treatment can improve vaginal health and sexual function, and restore vaginal biomechanical properties by increasing vaginal tissue tightening and improving vaginal tissue integrity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jianru Chen, Weinan Guo, Pengran Du, Tingting Cui, Yuqi Yang, Yinghan Wang, Pan Kang, Zhe Zhang, Qi Wang, Zhubiao Ye, Ling Liu, Zhe Jian, Tianwen Gao, Huijie Bian, Shuli Li, Chunying Li
Summary: This study found that MIF is overabundant in vitiligo patients and a mouse model for human vitiligo. Inhibiting MIF can ameliorate vitiligo progression by suppressing the infiltration of CD8(+) T cells and protecting epidermal melanocytes. This suggests that MIF may be a potential target for vitiligo treatment.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiuli Yi, Huina Wang, Yuqi Yang, Hao Wang, Hengxiang Zhang, Sen Guo, Jianru Chen, Juan Du, Yangzi Tian, Jingjing Ma, Baolu Zhang, Lili Wu, Qiong Shi, Tianwen Gao, Weinan Guo, Chunying Li
Summary: Melanoma is a deadly type of skin cancer originating from the transformation of melanocyte. The SIRT7 protein plays a crucial role in regulating tumor cell biology and tumor immunology in melanoma, promoting tumor cell survival and immune evasion. Targeting SIRT7 could restrain tumor growth and enhance the effect of melanoma immunotherapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Migara Kavishka Jayasinghe, Marco Pirisinu, Yuqi Yang, Boya Peng, Thach Tuan Pham, Chang Yu Lee, Melissa Tan, Luyen Tien Vu, Xuan T. T. Dang, Tin Chanh Pham, Huan Chen, Anskar Y. H. Leung, William C. Cho, Jiahai Shi, Minh T. N. Le
Summary: The use of extracellular vesicles (EVs) as drug delivery vectors has gained attention due to their ability to efficiently deliver therapeutic payloads to diseased cells. Surface functionalization methods have been developed to enhance the stability and biocompatibility of EVs, allowing for targeted delivery to cancer cells and improved metastasis suppression. Extensive testing has shown that engineered EVs are biocompatible and safe for repeated dose treatment.