Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Medicinal
Jianru Chen, Shuli Li, Chunying Li
Summary: Vitiligo is an autoimmune depigment disease caused by the destruction of melanocytes due to various factors, including genetic susceptibility, oxidative stress, and immune dysfunction. Research suggests that most melanocyte deaths are a result of abnormal immune responses, including heightened innate immunity, skewed T helper cells, and cytotoxic T lymphocytes.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Asako Yamamoto, Lingli Yang, Yasutaka Kuroda, Jiao Guo, Lanting Teng, Daisuke Tsuruta, Ichiro Katayama
Summary: The skin, as the outermost barrier of the body, is a major target of oxidative stress. Local synthesis of estrogen in the skin to protect from oxidative stress has been explored, with abnormal local estrogen synthesis potentially involved in skin disorders. The findings suggest potential new intervention targets for combination therapy for conditions such as vitiligo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Prashiela Manga, Noshin Choudhury
Summary: Epidermal melanocytes are constantly exposed to environmental stressors such as ultraviolet light and chemotoxins, deploying survival mechanisms like the unfolded protein response (UPR) and integrated stress response (ISR). While UPR/ISR promote restoration of homeostasis, they can also support disease development like melanoma and vitiligo.
PIGMENT CELL & MELANOMA RESEARCH
(2021)
Review
Cell Biology
Wei-Ling Chang, Chi-Hsiang Ko
Summary: Vitiligo is an autoimmune skin disorder caused by dysfunctional pigment-producing melanocytes which are attacked by immune cells. Oxidative stress is considered to play a crucial role in activating consequent autoimmune responses related to vitiligo. This report provides new perspectives and advances our understanding of interrelationships between oxidative stress and autoimmunity in the pathogenesis of vitiligo. Progress with targeted antioxidant therapy is described, with the aim of providing potential therapeutic approaches.
Review
Plant Sciences
Yeeun Kang, Kwanuk Lee, Ken Hoshikawa, Myeongyong Kang, Seonghoe Jang
Summary: The effects of climate change, such as increased global temperatures and abnormal weather events, are causing concerns for plant vegetation and crop productivity. This review focuses on the molecular processes of plants in response to heat stress, with emphasis on the classification and functions of heat shock proteins. Developing vegetable crops with enhanced thermotolerance using genetic tools is crucial to alleviate the adverse effects of heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Darae Kang, Kwanseob Shim
Summary: The study showed that early heat conditioning can reduce the negative impacts of acute heat stress on broilers by regulating heat shock proteins and corticosterone levels.
Article
Oncology
Xiuyi Wu, Shanglin Jin, Yiwen Yang, Xiaoli Lu, Xiaoxi Dai, Zhongyi Xu, Chengfeng Zhang, Leihong Flora Xiang
Summary: The expression of ferroptosis markers is altered in the epidermis of vitiligo patients and iron deficiency is revealed in their blood. Erastin induces ferroptosis in human epidermal MCs in vitro, while NAC protects MCs from ferroptosis.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Article
Horticulture
Chao Gong, Qiangqiang Pang, Zhiliang Li, Zhenxing Li, Riyuan Chen, Guangwen Sun, Baojuan Sun
Summary: Under high temperature stress, Hsf and Hsp gene families are activated in eggplant cells, enhancing thermotolerance by removing denatured proteins. Specifically, upon exposure to heat stress, the majority of Hsf and Hsp genes in eggplant show increased expression levels.
Article
Environmental Sciences
Chao Xing, Jinyu Li, Hongli Yuan, Jinshui Yang
Summary: This study investigated the response mechanism of microalgae under heat and cold stress. The results showed that heat stress led to a significant increase in reactive oxygen species, while cold stress initially increased and then decreased reactive oxygen species. Key elements such as superoxide dismutase and nitric oxide increased under heat stress, while proline and heat shock transcriptional factor increased under cold stress. This study provides a basis for understanding the response mechanism of microalgae to temperature stress and improving their tolerance to temperature stress.
ENVIRONMENTAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Sharif Hasan Siddiqui, Mousumee Khan, Hosung Choe, Darae Kang, Kwanseob Shim
Summary: This study investigated the structure and functional expression of heat shock proteins (HSPs) in different chicken organs using meta-analysis. The results showed that the expression of HSPs varied among different organs and under different stress levels. Heat stress significantly changed the expression of HSP70 in the chicken liver. The findings highlight the diverse expression patterns of HSPs in chicken organs.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Hyung-Eun Kim, Jong-Eun Han, Hosakatte Niranjana Murthy, Hyuk-Joon Kwon, Gun-Myung Lee, So-Young Park
Summary: This study evaluated the heat tolerance of ten clones of Cnidium officinale from Korea and identified two heat-tolerant clones that can be used for further evaluation and cultivation.
Review
Plant Sciences
Yunzhuan Zhou, Fuxiang Xu, Yanan Shao, Junna He
Summary: As global warming intensifies, the earth's average temperature continues to rise. Plants have developed two main mechanisms, the heat stress response and the thermomorphogenesis response, to cope with elevated temperatures. This review summarizes recent progress in understanding these heat-responsive molecular regulatory pathways in plants and discusses future perspectives in this field.
Article
Plant Sciences
Woo Joo Jung, Chan Seop Ko, Yong Weon Seo
Summary: Through RNA-seq analysis of oat spikelets under high temperatures, we found changes in gene expression, with upregulation of glutathione and flavonoid pathways and downregulation of DNA replication and fatty acid elongation. Additionally, we identified 823 heat shock protein gene families in the oat genome and observed their expression at different temperatures, which can help in understanding heat response in oat.
PLANT GROWTH REGULATION
(2023)
Review
Medicine, General & Internal
Prathmesh Nimkar, Anil Wanjari
Summary: Significant progress has been made in understanding the etiology of vitiligo, which is now recognized as an autoimmune disease caused by a combination of genetic mutations and various other factors. Vitiligo is not just a cosmetic issue, but can also have psychological implications and interfere with daily activities.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Oncology
Jonathan M. Eby, Levi Barse, Steven W. Henning, Martijn J. W. E. Rabelink, Jared Klarquist, Emily R. Gilbert, Adam M. Hammer, Manuel F. Fernandez, Nathan Yung, Safia Khan, Hannah G. Miller, Edward R. Kessler, Elizabeth Garrett-Mayer, Daniel F. Dilling, Rob C. Hoeben, I. Caroline Le Poole
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)
Article
Cell Biology
Jonathan M. Eby, Hazem Abdelkarim, Lauren J. Albee, Abhishek Tripathi, Xianlong Gao, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Article
Computer Science, Information Systems
Charu Khatwani, Xiaoyu Jin, Nan Niu, Amy Koshoffer, Linda Newman, Juha Savolainen
REQUIREMENTS ENGINEERING
(2017)
Article
Oncology
Jonathan M. Eby, Angela R. Smith, Timothy P. Riley, Cormac Cosgrove, Christian M. Ankney, Steven W. Henning, Chrystal M. Paulos, Elizabeth Garrett-Mayer, Rosalie M. Luiten, Michael I. Nishimura, Brian M. Baker, I. Caroline Le Poole
PIGMENT CELL & MELANOMA RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Lauren J. Albee, Heather M. LaPorte, Xianlong Gao, Jonathan M. Eby, You-Hong Cheng, Amanda M. Nevins, Brian F. Volkman, Vadim Gaponenko, Matthias Majetschak
Article
Biochemistry & Molecular Biology
Ben Hitchinson, Jonathan M. Eby, Xianlong Gao, Francois Guite-Vinet, Joshua J. Ziarek, Hazem Abdelkarim, Youngshim Lee, Yukari Okamoto, Sojin Shikano, Matthias Majetschak, Nikolaus Heveker, Brian F. Volkman, Nadya I. Tarasova, Vadim Gaponenko
Article
Multidisciplinary Sciences
Jonathan M. Eby, Matthias Majetschak
Article
Substance Abuse
Farah Sharieh, Jonathan M. Eby, Philip M. Roper, John J. Callaci
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Information Science & Library Science
Joshua Sadvari, Amy Koshoffer, R. Benjamin Gorham, Katie Phillips
Summary: GIS Day is an annual celebration that allows organizations to showcase the real-world applications and positive societal impacts of geography and GIS, engage with campus and local communities, and demonstrate the educational and collaborative aspects of geospatial information services in libraries. Many academic libraries participate in GIS Day programs, using this opportunity to highlight their services and celebrate accomplishments.
JOURNAL OF MAP & GEOGRAPHY LIBRARIES
(2020)
Article
Substance Abuse
Jonathan M. Eby, Farah Sharieh, Jessica Azevedo, John J. Callaci
Summary: Alcohol exposure may affect fracture healing by inhibiting MSC chondrogenic differentiation. Animal experiments showed that alcohol administration reduced the fracture callus area and affected both early chondrogenic differentiation and later chondrocyte maturation.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Critical Care Medicine
Adam L. Gottula, Christopher R. Shaw, Kari L. Gorder, Bennett H. Lane, Jennifer Latessa, Man Qi, Amy Koshoffer, Rabab Al-Araji, Wesley Young, Jordan Bonomo, James R. Langabeer, Demetris Yannopoulos, Timothy D. Henry, Cindy H. Hsu, Justin L. Benoit
Summary: This study used a Geographic Information System (GIS) model to estimate the number of extracorporeal cardiopulmonary resuscitation (ECPR) candidates in the U.S., and found that less than 2% of out-of-hospital cardiac arrest (OHCA) patients are eligible for ECPR. The results indicate that clinical criteria, transportation time, and hospital capabilities have an impact on ECPR eligibility, and can inform future implementation strategies.
Article
Biochemistry & Molecular Biology
Esha M. Kapania, Taylor J. Reif, Aaron Tsumura, Jonathan M. Eby, John J. Callaci
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2020)
Article
Public Administration
Edward Wallace
JOURNAL OF PUBLIC AFFAIRS
(2019)
Correction
Oncology
Tamson Moore, Courtney Regan Wagner, Gina M. Scurti, Kelli A. Hutchens, Constantine Godellas, Ann Lau Clark, Elizabeth Motunrayo Kolawole, Lance M. Hellman, Nishant K. Singh, Fernando A. Huyke, Siao-Yi Wang, Kelly M. Calabrese, Heather D. Embree, Rimas Orentas, Keisuke Shirai, Emilia Dellacecca, Elizabeth Garrett-Mayer, Mingli Li, Jonathan M. Eby, Patrick J. Stiff, Brian D. Evavold, Brian M. Baker, I. Caroline Le Poole, Boro Dropulic, Joseph I. Clark, Michael I. Nishimura
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)
Article
Oncology
Tamson Moore, Courtney Regan Wagner, Gina M. Scurti, Kelli A. Hutchens, Constantine Godellas, Ann Lau Clark, Elizabeth Motunrayo Kolawole, Lance M. Hellman, Nishant K. Singh, Fernando A. Huyke, Siao-Yi Wang, Kelly M. Calabrese, Heather D. Embree, Rimas Orentas, Keisuke Shirai, Emilia Dellacecca, Elizabeth Garrett-Mayer, Mingli Li, Jonathan M. Eby, Patrick J. Stiff, Brian D. Evavold, Brian M. Baker, I. Caroline Le Poole, Boro Dropulic, Joseph I. Clark, Michael I. Nishimura
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2018)