Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2023-03-09
DOI
10.3389/fimmu.2023.1123853
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Crosstalk between β-Catenin and CCL2 Drives Migration of Monocytes towards Glioblastoma Cells
- (2022) Philippe Aretz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- STAT3 is a biologically relevant therapeutic target in H3K27M-mutant diffuse midline glioma
- (2022) Liang Zhang et al. NEURO-ONCOLOGY
- Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma
- (2022) Wenjing Xuan et al. Cancer Immunology Research
- Single-Cell Transcriptomics Revealed Subtype-Specific Tumor Immune Microenvironments in Human Glioblastomas
- (2022) Yong Xiao et al. Frontiers in Immunology
- The Pivotal Immunoregulatory Functions of Microglia and Macrophages in Glioma Pathogenesis and Therapy
- (2022) Seidu A. Richard Journal of Oncology
- Glioma-Associated Microglia Characterization in the Glioblastoma Microenvironment through A ‘Seed-and Soil’ Approach: A Systematic Review
- (2022) Grazia Menna et al. Brain Sciences
- A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma
- (2022) John de Groot et al. CNS oncology
- β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages
- (2022) Daqi Li et al. CANCER RESEARCH
- IFN-γ induces PD-L1 through p38/JNK/ERK signaling pathways and counteracts the tumor promoting effect mediated by PD-L1 in Glioblastoma
- (2022) Huafang Jia et al. Computational Intelligence and Neuroscience
- Hypoxia-Driven M2-Polarized Macrophages Facilitate Cancer Aggressiveness and Temozolomide Resistance in Glioblastoma
- (2022) Ge Zhang et al. Oxidative Medicine and Cellular Longevity
- Origin, activation, and targeted therapy of glioma-associated macrophages
- (2022) Can Xu et al. Frontiers in Immunology
- LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
- (2022) Jinyang Hu et al. Journal for ImmunoTherapy of Cancer
- RNA ‐binding protein DHX9 promotes glioma growth and tumor‐associated macrophages infiltration via TCF12
- (2022) Liang Liu et al. CNS Neuroscience & Therapeutics
- ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells
- (2022) Zijie Gao et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism
- (2022) Yunfei Liao et al. Cell Death & Disease
- Correlation between brain functional connectivity and neurocognitive function in patients with left frontal glioma
- (2022) Masaya Ueda et al. Scientific Reports
- Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR–STAT3 signalling
- (2021) Xinya Gao et al. NATURE CELL BIOLOGY
- Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment
- (2021) Lesang Shen et al. Oxidative Medicine and Cellular Longevity
- Current status of antigen-specific T-cell immunotherapy for advanced renal-cell carcinoma
- (2021) Yuexin Xu et al. Human Vaccines & Immunotherapeutics
- Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival
- (2021) Erin E. Crotty et al. JOURNAL OF NEURO-ONCOLOGY
- PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
- (2021) Jie Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma
- (2021) Joseph H. Choe et al. Science Translational Medicine
- Electrospun meshes intrinsically promote M2 polarization of microglia under hypoxia and offer protection from hypoxia-driven cell death
- (2021) Dhivya Venugopal et al. Biomedical Materials
- The multifactorial roles of microglia and macrophages in the maintenance and progression of glioblastoma
- (2021) Rishabh Chaudhary et al. JOURNAL OF NEUROIMMUNOLOGY
- Crosstalk Between Tumor-Associated Microglia/Macrophages and CD8-Positive T Cells Plays a Key Role in Glioblastoma
- (2021) Sheng Tu et al. Frontiers in Immunology
- The Interplay between Glioblastoma and Its Microenvironment
- (2021) Mark Dapash et al. Cells
- Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial
- (2021) E Antonio Chiocca et al. NEURO-ONCOLOGY
- Glioblastoma genetic drivers dictate the function of tumor-associated macrophages/microglia and responses to CSF1R inhibition
- (2021) Rohit Rao et al. NEURO-ONCOLOGY
- An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
- (2021) Bo Xu et al. Nature Communications
- Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
- (2020) Peiwen Chen et al. Cancer Discovery
- Extracellular Vesicles in Glioblastoma Tumor Microenvironment
- (2020) Anuroop Yekula et al. Frontiers in Immunology
- Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis
- (2020) Miriam Mecha et al. Journal of Neuroinflammation
- CCR2 is localized in microglia and neurons, as well as infiltrating monocytes, in the lumbar spinal cord of ALS mice
- (2020) Hiroyasu Komiya et al. Molecular Brain
- Anti–PD-1 Induces M1 Polarization in the Glioma Microenvironment and Exerts Therapeutic Efficacy in the Absence of CD8 Cytotoxic T Cells
- (2020) Ganesh Rao et al. CLINICAL CANCER RESEARCH
- Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment
- (2020) Anaelle A Dumas et al. EMBO JOURNAL
- Repeat radiation with bevacizumab and minocycline in bevacizumab-refractory high grade gliomas: a prospective phase 1 trial
- (2020) Adam L. Cohen et al. JOURNAL OF NEURO-ONCOLOGY
- IL-4 Switches Microglia/macrophage M1/M2 Polarization and Alleviates Neurological Damage by Modulating the JAK1/STAT6 Pathway Following ICH
- (2020) Yang He et al. NEUROSCIENCE
- A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways
- (2020) Siobhan S. Pattwell et al. Nature Communications
- CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology
- (2020) Matthäus Felsenstein et al. Cancers
- Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies
- (2020) Kevin R. Parker et al. CELL
- IL-6: An endogenous activator of MMP-9 in preterm birth
- (2020) Monika Pandey et al. JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
- (2020) Astrid De Boeck et al. Nature Communications
- Affective Immunology: The Crosstalk Between Microglia and Astrocytes Plays Key Role?
- (2020) Linglin Yang et al. Frontiers in Immunology
- Identification of Immune Cell Infiltration and Immune-Related Genes in the Tumor Microenvironment of Glioblastomas
- (2020) Sicong Huang et al. Frontiers in Immunology
- Molecular Profiling of the Tumor Microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival
- (2019) Marko Gjorgjevski et al. BIOSCIENCE REPORTS
- Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma
- (2019) Sameer A Greenall et al. NEURO-ONCOLOGY
- Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma
- (2019) Peiwen Chen et al. CANCER CELL
- Harnessing Microglia and Macrophages for the Treatment of Glioblastoma
- (2019) Ioanna Prionisti et al. Frontiers in Pharmacology
- Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma
- (2019) Reena P Thomas et al. CLINICAL CANCER RESEARCH
- Increased expression of MMP-2 and MMP-9 indicates poor prognosis in glioma recurrence
- (2019) Wei Zhou et al. BIOMEDICINE & PHARMACOTHERAPY
- CCL5 of glioma-associated microglia/macrophages regulates glioma migration and invasion via calcium-dependent matrix metalloproteinase 2
- (2019) Caren Yu-Ju Wu et al. NEURO-ONCOLOGY
- Immune biology of glioma associated macrophages and microglia: Functional and therapeutic implications
- (2019) Jun Wei et al. NEURO-ONCOLOGY
- Brain malignancies: Glioblastoma and brain metastases
- (2019) Tamara T. Lah et al. SEMINARS IN CANCER BIOLOGY
- The Clinical and Immunologic Features of Patients With Combined Anti-GBM Disease and Castleman Disease
- (2018) Qiu-hua Gu et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- Phase I and biomarker study of plerixafor and bevacizumab in recurrent high-grade glioma
- (2018) Eudocia Q Lee et al. CLINICAL CANCER RESEARCH
- Microglia and Aging: The Role of the TREM2–DAP12 and CX3CL1-CX3CR1 Axes
- (2018) Carmen Mecca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
- (2018) Saskia Roesch et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma
- (2018) Linda M. Liau et al. Journal of Translational Medicine
- Development of third generation anti-EGFRvIII chimeric T cells and EGFRvIII-expressing artificial antigen presenting cells for adoptive cell therapy for glioma
- (2018) Ayguen Sahin et al. PLoS One
- Phytosomal curcumin causes natural killer cell-dependent repolarization of glioblastoma (GBM) tumor-associated microglia/macrophages and elimination of GBM and GBM stem cells
- (2018) Sumit Mukherjee et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas
- (2018) Pia S. Zeiner et al. BRAIN PATHOLOGY
- Intracerebral injection of CpG oligonucleotide for patients with de novo glioblastoma—A phase II multicentric, randomised study
- (2017) Renata Ursu et al. EUROPEAN JOURNAL OF CANCER
- The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies
- (2017) Changbin Zhu et al. NEURO-ONCOLOGY
- Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system
- (2017) Nils Lannes et al. Oncotarget
- Cellular and Molecular Characterization of Microglia: A Unique Immune Cell Population
- (2017) Carole Sousa et al. Frontiers in Immunology
- Time lapsein vivomicroscopy reveals distinct dynamics of microglia-tumor environment interactions-a new role for the tumor perivascular space as highway for trafficking microglia
- (2016) Simon Heinrich Bayerl et al. GLIA
- Targeting CXCR4 by a selective peptide antagonist modulates tumor microenvironment and microglia reactivity in a human glioblastoma model
- (2016) Laura Mercurio et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Macrophage Susceptibility to Emactuzumab (RG7155) Treatment
- (2016) Leon P. Pradel et al. MOLECULAR CANCER THERAPEUTICS
- Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
- (2016) H-J Kim et al. MOLECULAR PSYCHIATRY
- Sall1 is a transcriptional regulator defining microglia identity and function
- (2016) Anne Buttgereit et al. NATURE IMMUNOLOGY
- New tools for studying microglia in the mouse and human CNS
- (2016) Mariko L. Bennett et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia promotes glioma-associated macrophage infiltration via periostin and subsequent M2 polarization by upregulating TGF-beta and M-CSFR
- (2016) Xiaofan Guo et al. Oncotarget
- The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches
- (2016) Marco Mineo et al. Cell Reports
- Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
- (2016) Robert L. Bowman et al. Cell Reports
- Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors
- (2015) Susan Brandenburg et al. ACTA NEUROPATHOLOGICA
- Endocannabinoids drive the acquisition of an alternative phenotype in microglia
- (2015) M. Mecha et al. BRAIN BEHAVIOR AND IMMUNITY
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- (2015) Yu Tang et al. MOLECULAR NEUROBIOLOGY
- Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
- (2015) Wenchao Zhou et al. NATURE CELL BIOLOGY
- Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study
- (2015) Nicholas Butowski et al. NEURO-ONCOLOGY
- Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1
- (2015) Frank Szulzewsky et al. PLoS One
- Proinflammatory-Activated Glioma Cells Induce a Switch in Microglial Polarization and Activation Status, From a Predominant M2b Phenotype to a Mixture of M1 and M2a/B Polarized Cells
- (2014) Lucia Lisi et al. ASN Neuro
- Epidemiologic and Molecular Prognostic Review of Glioblastoma
- (2014) J. P. Thakkar et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline
- (2014) Feng Hu et al. INTERNATIONAL JOURNAL OF CANCER
- Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells
- (2014) Annett Müller et al. INTERNATIONAL JOURNAL OF CANCER
- Preferential In Situ CD4+CD56+ T Cell Activation and Expansion within Human Glioblastoma
- (2014) A. Waziri et al. JOURNAL OF IMMUNOLOGY
- Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling
- (2014) Feng Hu et al. NEURO-ONCOLOGY
- Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain
- (2014) Monica R.P. Elmore et al. NEURON
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- (2014) M. L. Davila et al. Science Translational Medicine
- GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis
- (2013) Min-Chi Ku et al. ACTA NEUROPATHOLOGICA
- Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
- (2013) Vibol Chhor et al. BRAIN BEHAVIOR AND IMMUNITY
- Unique transcriptome signature of mouse microglia
- (2013) Clara Beutner et al. GLIA
- Glioblastoma and Other Malignant Gliomas
- (2013) Antonio Omuro JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
- Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
- (2013) Susobhan Sarkar et al. NATURE NEUROSCIENCE
- Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion
- (2013) K. Vinnakota et al. NEURO-ONCOLOGY
- Microglia during development and aging
- (2013) G. Jean Harry PHARMACOLOGY & THERAPEUTICS
- Preconditioning of Microglia by α-Synuclein Strongly Affects the Response Induced by Toll-like Receptor (TLR) Stimulation
- (2013) Cintia Roodveldt et al. PLoS One
- T11TS inhibits glioma angiogenesis by modulation of MMPs, TIMPs, with related integrin αv and TGF-β1 expressions
- (2013) Manoj Kumar Singh et al. TUMOR BIOLOGY
- Tumor-Associated Microglia/Macrophages Enhance the Invasion of Glioma Stem-like Cells via TGF- 1 Signaling Pathway
- (2012) X.-z. Ye et al. JOURNAL OF IMMUNOLOGY
- Unknown
- (2012) Salvatore Coniglio et al. MOLECULAR MEDICINE
- A restricted cell population propagates glioblastoma growth after chemotherapy
- (2012) Jian Chen et al. NATURE
- Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype
- (2012) Y. Piao et al. NEURO-ONCOLOGY
- A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis
- (2011) J. Zhang et al. CARCINOGENESIS
- Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model
- (2011) Shu-Chi Wang et al. LABORATORY INVESTIGATION
- Enhanced anti-glioblastoma activity of microglia by AAV2-mediated IL-12 through TRAIL and phagocytosis in vitro
- (2011) Chiu ONCOLOGY REPORTS
- Direct In Vivo Evidence for Tumor Propagation by Glioblastoma Cancer Stem Cells
- (2011) Justin D. Lathia et al. PLoS One
- S100B attenuates microglia activation in gliomas: Possible role of STAT3 pathway
- (2010) Leying Zhang et al. GLIA
- Glioma-initiating cells: A predominant role in microglia/macrophages tropism to glioma
- (2010) Liang Yi et al. JOURNAL OF NEUROIMMUNOLOGY
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- Increase in tumor size following intratumoral injection of immunostimulatory CpG-containing oligonucleotides in a rat glioma model
- (2009) Christian Ginzkey et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
- (2009) Leying Zhang et al. GLIA
- Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1
- (2009) Saio INTERNATIONAL JOURNAL OF ONCOLOGY
- Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion
- (2009) D. S. Markovic et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth
- (2009) Hui Wang et al. STEM CELLS
- Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators
- (2008) H.-W. Lo et al. CLINICAL CANCER RESEARCH
- Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures
- (2008) Ryan J. Horvath et al. JOURNAL OF NEUROCHEMISTRY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started