A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma

STAT3 is required for Smo‐dependent signaling and mediates Smo‐targeted treatment resistance and tumorigenesis in Shh medulloblastoma

(2021) Liangping Yuan et al.   Molecular Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

(2021) David N Louis et al.   NEURO-ONCOLOGY

Radiation with STAT3 blockade triggers dendritic cell-T cell interactions in the glioma microenvironment and therapeutic efficacy

(2020) Martina Ott et al.   CLINICAL CANCER RESEARCH

MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide. A Pooled Analysis of Four Clinical Trials.

(2018) Monika E Hegi et al.   CLINICAL CANCER RESEARCH

WP1066 exhibits antitumor efficacy in nasal-type natural killer/T-cell lymphoma cells through downregulation of the STAT3 signaling pathway

(2016) Lingyun Geng et al.   ONCOLOGY REPORTS

Immunotherapy response assessment in neuro-oncology: a report of the RANO working group

(2015) Hideho Okada et al.   LANCET ONCOLOGY

Overcoming Chemoresistance of Pediatric Ependymoma by Inhibition of STAT3 Signaling

(2015) Ji Hoon Phi et al.   Translational Oncology

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

(2015) Hsueh-Te Lee et al.   Oncotarget

Treatment of Elderly Patients With Glioblastoma

(2015) Oren J. Zarnett et al.   JAMA Neurology

Modulating Antiangiogenic Resistance by Inhibiting the Signal Transducer and Activator of Transcription 3 Pathway in Glioblastoma

(2015) John de Groot et al.   Oncotarget

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

(2014) XUAN ZHOU et al.   ONCOLOGY REPORTS

Inhibition of the JAK2/STAT3 Pathway Reduces Gastric Cancer Growth In Vitro and In Vivo

(2014) Louise M. Judd et al.   PLoS One

STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression

(2012) Shinji Kohsaka et al.   MOLECULAR CANCER THERAPEUTICS

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells

(2011) Huan-Chih Chiu et al.   BIOCHEMICAL PHARMACOLOGY

The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models

(2011) Mustafa Aziz Hatiboglu et al.   INTERNATIONAL JOURNAL OF CANCER

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

(2010) A Horiguchi et al.   BRITISH JOURNAL OF CANCER

Inhibition of p-STAT3 Enhances IFN-  Efficacy against Metastatic Melanoma in a Murine Model

(2010) L. Y. Kong et al.   CLINICAL CANCER RESEARCH

Intratumoral Mediated Immunosuppression is Prognostic in Genetically Engineered Murine Models of Glioma and Correlates to Immunotherapeutic Responses

(2010) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Glioma cancer stem cells induce immunosuppressive macrophages/microglia

(2010) Adam Wu et al.   NEURO-ONCOLOGY

yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients

(2009) William Humphries et al.   Journal of Translational Medicine

STAT3 Is Required for Proliferation and Maintenance of Multipotency in Glioblastoma Stem Cells

(2009) Maureen M. Sherry et al.   STEM CELLS

A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells

(2008) Ling-Yuan Kong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

(2008) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas

(2008) M. Abou-Ghazal et al.   CLINICAL CANCER RESEARCH