Crosstalk between Macrophages, T Cells, and Iron Metabolism in Tumor Microenvironment

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

(2020) Naoya Yamada et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

(2020) Jackson G. Egen et al.   IMMUNITY

Hepatic Transferrin Plays a Role in Systemic Iron Homeostasis and Liver Ferroptosis

(2020) Yingying Yu et al.   BLOOD

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

(2020) Xuexian Fang et al.   CIRCULATION RESEARCH

HFE inhibits type I IFNs signaling by targeting the SQSTM1-mediated MAVS autophagic degradation

(2020) Juan Liu et al.   Autophagy

Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox

(2020) Shogo Amano et al.   BMC CANCER

Systematic review of the clinical outcomes of iron reduction in Hereditary Hemochromatosis

(2020) Anil Prabhu et al.   HEPATOLOGY

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

(2020) Laura Mahoney-Sánchez et al.   PROGRESS IN NEUROBIOLOGY

Ferroptosis in Acute Central Nervous System Injuries: The Future Direction?

(2020) Lesang Shen et al.   Frontiers in Cell and Developmental Biology

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

(2019) Seyed Mohammadali Dadfar et al.   ADVANCED DRUG DELIVERY REVIEWS

Iron as a Central Player and Promising Target in Cancer Progression

(2019) Michaela Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simultaneous T Cell Activation and Macrophage Polarization to Promote Potent Tumor Suppression by Iron Oxide-Embedded Large-Pore Mesoporous Organosilica Core-Shell Nanospheres

(2019) Lin Chen et al.   Advanced Healthcare Materials

Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

(2019) Chu-Xin Li et al.   ADVANCED MATERIALS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway

(2019) Zhengying Gu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Macrophages and Metabolism in the Tumor Microenvironment

(2019) Ilio Vitale et al.   Cell Metabolism

TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages

(2019) Kritika Sudan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation

(2019) Shabnam Shalapour et al.   IMMUNITY

Inflammation and Cancer: Triggers, Mechanisms, and Consequences

(2019) Florian R. Greten et al.   IMMUNITY

Natural killer cells: a review of biology, therapeutic potential and challenges in treatment of solid tumors

(2019) Khalil Choucair et al.   Future Oncology

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

(2019) Shuang Qin et al.   Molecular Cancer

H-Ferritin Affects Cisplatin-Induced Cytotoxicity in Ovarian Cancer Cells through the Modulation of ROS

(2019) Alessandro Salatino et al.   Oxidative Medicine and Cellular Longevity

Erastin/sorafenib induces cisplatin‑resistant non‑small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway

(2019) Yu Li et al.   Oncology Letters

Randomized Phase II Trial of Triapine-Cisplatin-Radiotherapy for Locally Advanced Stage Uterine Cervix or Vaginal Cancers

(2019) Charles A. Kunos et al.   Frontiers in Oncology

Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

(2019) Shehua Qian et al.   EPMA Journal

Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma

(2019) Lijia Luo et al.   BIOMATERIALS

Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer

(2019) Hai-Hong Zhou et al.   Frontiers in Oncology

Iron chelation inhibits cancer cell growth and modulates global histone methylation status in colorectal cancer

(2018) Lin-Lin Cao et al.   BIOMETALS

Significance of serum ferritin as a prognostic factor in advanced hepatobiliary cancer patients treated with Korean medicine: a retrospective cohort study

(2018) Anna Song et al.   BMC Complementary and Alternative Medicine

CD163 is required for protumoral activation of macrophages in human and murine sarcoma

(2018) Daisuke Shiraishi et al.   CANCER RESEARCH

Immune suppression and reversal of the suppressive tumor microenvironment

(2018) Kanako Shimizu et al.   INTERNATIONAL IMMUNOLOGY

The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers

(2018) Sandrine Tury et al.   JOURNAL OF PATHOLOGY

Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

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Thalassaemia

(2018) Ali T Taher et al.   LANCET

The significance, trafficking and determination of labile iron in cytosol, mitochondria and lysosomes

(2018) Huanhuan Lv et al.   Metallomics

Knockdown of zinc transporter ZIP8 expression inhibits neuroblastoma progression and metastasis in�vitro

(2018) Zhengrong Mei et al.   Molecular Medicine Reports

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells

(2018) Zhongguo Shan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells

(2018) Stephanie E. A. Burnell et al.   Scientific Reports

Ferroptosis: A Novel Anti-tumor Action for Cisplatin

(2018) Jipeng Guo et al.   Cancer Research and Treatment

Six-Transmembrane Epithelial Antigen of Prostate 3 Predicts Poor Prognosis and Promotes Glioblastoma Growth and Invasion

(2018) Mingzhi Han et al.   NEOPLASIA

Iron and Cancer

(2018) Suzy V. Torti et al.   Annual Review of Nutrition

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

VSIG-3 as a ligand of VISTA inhibits human T cell function

(2018) Jinghua Wang et al.   IMMUNOLOGY

Dual role of macrophage in tumor immunity

(2018) Ryota Tamura et al.   Immunotherapy

STEAP1 Regulates Tumorigenesis and Chemoresistance During Peritoneal Metastasis of Gastric Cancer

(2018) Yuan-Yu Wu et al.   Frontiers in Physiology

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

(2018) Ryan S. Lane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer immunoediting and resistance to T cell-based immunotherapy

(2018) Jake S. O’Donnell et al.   Nature Reviews Clinical Oncology

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Ferritin: A potential serum marker for lymph node metastasis in head and neck squamous cell carcinoma

(2018) Zhangwei Hu et al.   Oncology Letters

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

Tim-3 and its role in regulating anti-tumor immunity

(2017) Madhumita Das et al.   IMMUNOLOGICAL REVIEWS

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14

(2017) Ningning Zhao et al.   Nutrients

Serum ferritin in combination with prostate-specific antigen improves predictive accuracy for prostate cancer

(2017) Xijuan Wang et al.   Oncotarget

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages

(2017) Milene Costa da Silva et al.   Frontiers in Immunology

Iron Handling in Tumor-Associated Macrophages—Is There a New Role for Lipocalin-2?

(2017) Michaela Jung et al.   Frontiers in Immunology

Hemojuvelin regulates the innate immune response to peritoneal bacterial infection in mice

(2017) Qian Wu et al.   Cell Discovery

Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation

(2016) Seung Min Jeong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Local iron homeostasis in the breast ductal carcinoma microenvironment

(2016) Oriana Marques et al.   BMC CANCER

EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1

(2016) Biao Wang et al.   CANCER LETTERS

Iron Uptake via DMT1 Integrates Cell Cycle with JAK-STAT3 Signaling to Promote Colorectal Tumorigenesis

(2016) Xiang Xue et al.   Cell Metabolism

Transcriptional Landscape of Human Tissue Lymphocytes Unveils Uniqueness of Tumor-Infiltrating T Regulatory Cells

(2016) Marco De Simone et al.   IMMUNITY

The impact of hypoxia on tumor-associated macrophages

(2016) Anne-Theres Henze et al.   JOURNAL OF CLINICAL INVESTIGATION

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

(2016) Takuro Saito et al.   NATURE MEDICINE

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

(2016) Saeid Zanganeh et al.   Nature Nanotechnology

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression

(2016) Christina Mertens et al.   PLoS One

Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

(2016) Michaela Jung et al.   Science Signaling

Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer

(2016) Sarah Knocke et al.   Cell Reports

Serum Ferritin as a Prognostic Biomarker for Survival in Relapsed or Refractory Metastatic Colorectal Cancer

(2016) Sookyung Lee et al.   Journal of Cancer

Lipocalin 2 from macrophages stimulated by tumor cell–derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis

(2016) Michaela Jung et al.   Science Signaling

Hepcidin: regulation of the master iron regulator

(2015) Gautam Rishi et al.   BIOSCIENCE REPORTS

Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer

(2015) Lia Tesfay et al.   CANCER RESEARCH

Hepcidin and ferroportin expression in breast cancer tissue and serum and their relationship with anemia

(2015) X. Pan et al.   Current Oncology

Macrophage iron homeostasis and polarization in the context of cancer

(2015) Michaela Jung et al.   IMMUNOBIOLOGY

Immunity, inflammation, and cancer: an eternal fight between good and evil

(2015) Shabnam Shalapour et al.   JOURNAL OF CLINICAL INVESTIGATION

From mice to humans: developments in cancer immunoediting

(2015) Michele W.L. Teng et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunosuppressive cells in tumor immune escape and metastasis

(2015) Yang Liu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

(2015) Haifa H Jabara et al.   NATURE GENETICS

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-γ-lyase function

(2015) LIANGYU CHEN et al.   ONCOLOGY REPORTS

Evolution of the immune system in humans from infancy to old age

(2015) A. Katharina Simon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Iron metabolism and iron supplementation in cancer patients

(2015) Heinz Ludwig et al.   WIENER KLINISCHE WOCHENSCHRIFT

Decreased expression of ferroportin in prostate cancer

(2015) DONG XUE et al.   Oncology Letters

Targeting cancer by binding iron: Dissecting cellular signaling pathways

(2015) Goldie Y.L. Lui et al.   Oncotarget

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response

(2015) Eliano Bonaccorsi-Riani et al.   PLoS One

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Disordered hepcidin–ferroportin signaling promotes breast cancer growth

(2014) Shuping Zhang et al.   CELLULAR SIGNALLING

New insights into cancer immunoediting and its three component phases—elimination, equilibrium and escape

(2014) Deepak Mittal et al.   CURRENT OPINION IN IMMUNOLOGY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Conditional Deletion of Ferritin H in Mice Reduces B and T Lymphocyte Populations

(2014) Liviu Vanoaica et al.   PLoS One

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages

(2013) Ahmed A. Alkhateeb et al.   BREAST CANCER RESEARCH AND TREATMENT

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Increased hepcidin expression in non-small cell lung cancer tissue and serum is associated with clinical stage

(2013) Qian Chen et al.   Thoracic Cancer

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

ZIP8 Is an Iron and Zinc Transporter Whose Cell-surface Expression Is Up-regulated by Cellular Iron Loading

(2012) Chia-Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

The transferrin receptor and the targeted delivery of therapeutic agents against cancer

(2011) Tracy R. Daniels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study

(2011) Joseph Chao et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

(2011) S.-R. Woo et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

H Ferritin Gene Silencing in a Human Metastatic Melanoma Cell Line: A Proteomic Analysis

(2011) Maddalena Di Sanzo et al.   JOURNAL OF PROTEOME RESEARCH

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype

(2011) Gaetano Cairo et al.   TRENDS IN IMMUNOLOGY

Role of ferritin alterations in human breast cancer cells

(2010) Svitlana I. Shpyleva et al.   BREAST CANCER RESEARCH AND TREATMENT

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Low numbers of CD8+T lymphocytes in hereditary haemochromatosis are explained by a decrease of the most mature CD8+effector memory T cells

(2010) M. F. Macedo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

(2010) S. Marro et al.   HAEMATOLOGICA

Hemochromatosis gene (HFE) mutations and cancer risk: Expanding the clinical manifestations of hereditary iron overload

(2010) Silvia Fargion et al.   HEPATOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

(2010) Z. K. Pinnix et al.   Science Translational Medicine

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

(2009) M. Nairz et al.   BLOOD

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

(2009) Junko H. Ohyashiki et al.   CANCER SCIENCE

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network

(2008) Martina U. Muckenthaler et al.   Annual Review of Nutrition

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE