Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment
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Title
Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment
Authors
Keywords
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Journal
EMBO JOURNAL
Volume 39, Issue 15, Pages -
Publisher
EMBO
Online
2020-06-23
DOI
10.15252/embj.2019103790
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Note: Only part of the references are listed.- In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells
- (2019) Jian Yang et al. Nature Protocols
- Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma
- (2019) Verena Haage et al. Acta Neuropathologica Communications
- Challenges to curing primary brain tumours
- (2019) Kenneth Aldape et al. Nature Reviews Clinical Oncology
- The landscape of the mesenchymal signature in brain tumours
- (2019) Jinan Behnan et al. BRAIN
- ERK1/2 signaling regulates the immune microenvironment and macrophage recruitment in glioblastoma
- (2019) Claire Lailler et al. BIOSCIENCE REPORTS
- Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E
- (2019) Ying Zhang et al. CANCER RESEARCH
- Phospho-mTOR expression in human glioblastoma microglia-macrophage cells
- (2019) Lucia Lisi et al. NEUROCHEMISTRY INTERNATIONAL
- Computational characterization of suppressive immune microenvironments in glioblastoma
- (2018) Suvi Luoto et al. CANCER RESEARCH
- Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer
- (2018) Xianmin Mu et al. CELL CYCLE
- T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
- (2018) Karolina Woroniecka et al. CLINICAL CANCER RESEARCH
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma
- (2018) Saskia Roesch et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- DNA methylation-based classification of central nervous system tumours
- (2018) David Capper et al. NATURE
- Immune Microenvironment in Glioblastoma Subtypes
- (2018) Zhihong Chen et al. Frontiers in Immunology
- Targeting mTOR in Glioblastoma: Rationale and Preclinical/Clinical Evidence
- (2018) Carmen Mecca et al. DISEASE MARKERS
- Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
- (2018) Jun Wei et al. JOURNAL OF CLINICAL INVESTIGATION
- LAG-3: a very singular immune checkpoint
- (2018) Yuan Lui et al. NATURE IMMUNOLOGY
- MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells
- (2017) Russell G. Jones et al. IMMUNITY
- Targeting tumor associated macrophages (TAMs) via nanocarriers
- (2017) Yuvraj Singh et al. JOURNAL OF CONTROLLED RELEASE
- The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment
- (2017) Nakho Chang et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development
- (2017) Hua-fu Zhao et al. Molecular Cancer
- Establishment of mouse expanded potential stem cells
- (2017) Jian Yang et al. NATURE
- Salmon provides fast and bias-aware quantification of transcript expression
- (2017) Rob Patro et al. NATURE METHODS
- Differentiation of human and murine induced pluripotent stem cells to microglia-like cells
- (2017) Hetal Pandya et al. NATURE NEUROSCIENCE
- CCL2/CCR2 signaling pathway in glioblastoma multiforme
- (2017) Alireza Vakilian et al. NEUROCHEMISTRY INTERNATIONAL
- iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases
- (2017) Edsel M. Abud et al. NEURON
- Tumour-associated microglia/macrophages predict poor prognosis in high-grade gliomas and correlate with an aggressive tumour subtype
- (2017) M. D. Sørensen et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas
- (2017) D Yan et al. ONCOGENE
- T Cell Exhaustion in Glioblastoma: Intricacies of Immune Checkpoints
- (2017) Reza Mirzaei et al. TRENDS IN IMMUNOLOGY
- Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma
- (2017) Sara Badodi et al. Cell Reports
- Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma
- (2017) Spyros Darmanis et al. Cell Reports
- The Effect of Osteopontin on Microglia
- (2017) Huan Yu et al. Biomed Research International
- Directed Differentiation of Human Pluripotent Stem Cells to Microglia
- (2017) Panagiotis Douvaras et al. Stem Cell Reports
- Structural insights of mTOR complex 1
- (2016) Hai-Xin Yuan et al. CELL RESEARCH
- Role of mTOR in glioblastoma
- (2016) Zekeriya Duzgun et al. GENE
- Human glioblastoma-associated microglia/monocytes express a distinct RNA profile compared to human control and murine samples
- (2016) Frank Szulzewsky et al. GLIA
- Inhibition of the PI3K/AKT/mTOR Pathway in Solid Tumors
- (2016) Patricia Mucci LoRusso JOURNAL OF CLINICAL ONCOLOGY
- Efficient derivation of microglia-like cells from human pluripotent stem cells
- (2016) Julien Muffat et al. NATURE MEDICINE
- The role of microglia and macrophages in glioma maintenance and progression
- (2016) Dolores Hambardzumyan et al. NATURE NEUROSCIENCE
- GlioVis data portal for visualization and analysis of brain tumor expression datasets
- (2016) Robert L. Bowman et al. NEURO-ONCOLOGY
- Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression
- (2016) A Ellert-Miklaszewska et al. ONCOGENE
- The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
- (2016) D. F. Quail et al. SCIENCE
- Proteome and Secretome Characterization of Glioblastoma-Derived Neural Stem Cells
- (2016) Satoshi Okawa et al. STEM CELLS
- The Taming of the TAMs
- (2016) Joan Seoane TRENDS IN CELL BIOLOGY
- PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma
- (2016) Xiaoman Li et al. Oncotarget
- Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
- (2016) Robert L. Bowman et al. Cell Reports
- Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance
- (2016) Susana Romero-Garcia et al. Frontiers in Immunology
- Macrophages and Therapeutic Resistance in Cancer
- (2015) Brian Ruffell et al. CANCER CELL
- Hypoxia, cancer metabolism and the therapeutic benefit of targeting lactate/H+ symporters
- (2015) Ibtissam Marchiq et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1
- (2015) Frank Szulzewsky et al. PLoS One
- Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells
- (2014) Annett Müller et al. INTERNATIONAL JOURNAL OF CANCER
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Making new contacts: the mTOR network in metabolism and signalling crosstalk
- (2014) Mitsugu Shimobayashi et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Using high-density DNA methylation arrays to profile copy number alterations
- (2014) Andrew Feber et al. GENOME BIOLOGY
- Causal analysis approaches in Ingenuity Pathway Analysis
- (2013) Andreas Krämer et al. BIOINFORMATICS
- The Controversial Role of Microglia in Malignant Gliomas
- (2013) Jun Wei et al. Clinical & Developmental Immunology
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- CSF-1R inhibition alters macrophage polarization and blocks glioma progression
- (2013) Stephanie M Pyonteck et al. NATURE MEDICINE
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma
- (2012) Dominik Sturm et al. CANCER CELL
- Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
- (2012) Simon Yona et al. IMMUNITY
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips
- (2012) Jovana Maksimovic et al. GENOME BIOLOGY
- Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development
- (2011) Jia Zou et al. DEVELOPMENTAL CELL
- Targeted delivery of oligonucleotides into tumor-associated macrophages for cancer immunotherapy
- (2011) Zhen Huang et al. JOURNAL OF CONTROLLED RELEASE
- Secretome Signature of Invasive Glioblastoma Multiforme
- (2011) Catherine A. Formolo et al. JOURNAL OF PROTEOME RESEARCH
- Glioblastoma cell secretome: Analysis of three glioblastoma cell lines reveal 148 non-redundant proteins
- (2011) Ravindra V. Polisetty et al. Journal of Proteomics
- Osteopontin is up-regulated and associated with neutrophil and macrophage infiltration in glioblastoma
- (2010) Nadia A. Atai et al. IMMUNOLOGY
- CD8+ T-cell infiltrate in newly diagnosed glioblastoma is associated with long-term survival
- (2010) Isaac Yang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Osteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
- (2010) Mansoor Ahmed et al. Molecular Cancer
- Immunotherapy coming of age: What will it take to make it standard of care for glioblastoma?
- (2010) A. B. Heimberger et al. NEURO-ONCOLOGY
- Glioma cancer stem cells induce immunosuppressive macrophages/microglia
- (2010) Adam Wu et al. NEURO-ONCOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens
- (2009) Steven M. Pollard et al. Cell Stem Cell
- Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes
- (2009) Thomas S Jacques et al. EMBO JOURNAL
- Stat3 inhibition activates tumor macrophages and abrogates glioma growth in mice
- (2009) Leying Zhang et al. GLIA
- Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model
- (2009) Virginie Lamour et al. INTERNATIONAL JOURNAL OF CANCER
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Incidence and Prognostic Impact of FoxP3+ Regulatory T Cells in Human Gliomas
- (2008) A. B. Heimberger et al. CLINICAL CANCER RESEARCH
- The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
- (2008) Thomas Weichhart et al. IMMUNITY
- Possible involvement of the M2 anti-inflammatory macrophage phenotype in growth of human gliomas
- (2008) Y Komohara et al. JOURNAL OF PATHOLOGY
- p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
- (2008) Hongwu Zheng et al. NATURE
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