CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

(2019) Joseph A. Flores-Toro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

(2018) Saskia Roesch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IFNAR1 Controls Autocrine Type I IFN Regulation of PD-L1 Expression in Myeloid-Derived Suppressor Cells

(2018) Wei Xiao et al.   JOURNAL OF IMMUNOLOGY

Microvascular Mural Cell Organotypic Heterogeneity and Functional Plasticity

(2018) Annegret Holm et al.   TRENDS IN CELL BIOLOGY

Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion

(2018) Flávia Castro et al.   Frontiers in Immunology

The roles of microglia macrophages in tumor progression of brain cancer and metastatic disease

(2017) Shih-Ying Wu   Frontiers in Bioscience-Landmark

Myeloid cells expressing high level of CD45 are associated with a distinct activated phenotype in glioma

(2017) Susan Brandenburg et al.   IMMUNOLOGIC RESEARCH

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome

(2017) Hashem O. Alsaab et al.   Frontiers in Pharmacology

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Blocking the CCL2–CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model

(2016) Kun-Yu Teng et al.   MOLECULAR CANCER THERAPEUTICS

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Macrophage and Cancer Cell Cross-talk via CCR2 and CX3CR1 Is a Fundamental Mechanism Driving Lung Cancer

(2015) Anja Schmall et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PD-L1 expression and prognostic impact in glioblastoma

(2015) Edjah K. Nduom et al.   NEURO-ONCOLOGY

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

(2015) Frank Szulzewsky et al.   PLoS One

CCR2 inhibition sequesters multiple subsets of leukocytes in the bone marrow

(2015) Naoki Fujimura et al.   Scientific Reports

CNS macrophages and peripheral myeloid cells in brain tumours

(2014) Rainer Glass et al.   ACTA NEUROPATHOLOGICA

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Resident microglia, and not peripheral macrophages, are the main source of brain tumor mononuclear cells

(2014) Annett Müller et al.   INTERNATIONAL JOURNAL OF CANCER

Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis

(2013) D. E. Sanford et al.   CLINICAL CANCER RESEARCH

Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia

(2013) Aleksandra Ellert-Miklaszewska et al.   GLIA

Vascular remodeling in cancer

(2013) R H Farnsworth et al.   ONCOGENE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Importance of direct macrophage - Tumor cell interaction on progression of human glioma

(2012) Yoshihiro Komohara et al.   CANCER SCIENCE

Dissecting the Autocrine and Paracrine Roles of the CCR2-CCL2 Axis in Tumor Survival and Angiogenesis

(2012) Liat Izhak et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Monocyte-Derived Cells of the Brain and Malignant Gliomas: The Double Face of Janus

(2012) Sergiy V. Kushchayev et al.   World Neurosurgery

A dialog between glioma and microglia that promotes tumor invasiveness through the CCL2/CCR2/interleukin-6 axis

(2011) J. Zhang et al.   CARCINOGENESIS

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Microglia in the CNS: Immigrants from another world

(2010) Marco Prinz et al.   GLIA

Microglia/macrophages promote glioma progression

(2010) Haiyan Zhai et al.   GLIA

CD13 is dispensable for normal hematopoiesis and myeloid cell functions in the mouse

(2010) B. Winnicka et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

(2010) Xinmei Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

(2009) Randy L. Jensen   JOURNAL OF NEURO-ONCOLOGY

BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas

(2009) T. R. Burton et al.   JOURNAL OF NEUROSCIENCE

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

(2008) Naoki Umemura et al.   JOURNAL OF LEUKOCYTE BIOLOGY