Recent advances in ZBP1-derived PANoptosis against viral infections

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

(2022) Daniel S. Simpson et al.   IMMUNITY

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic Pathways

(2022) Hussin A. Rothan et al.   Pathogens

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

(2022) Ting Zhang et al.   NATURE

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation

(2022) Sharath Basavaraju et al.   mBio

ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection

(2022) Rajendra Karki et al.   Science Immunology

ADAR1 mutation causes ZBP1-dependent immunopathology

(2022) Nicholas W. Hubbard et al.   NATURE

ADAR1 averts fatal type I interferon induction by ZBP1

(2022) Huipeng Jiao et al.   NATURE

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

(2022) Richard de Reuver et al.   NATURE

ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1

(2021) Hayley I. Muendlein et al.   Nature Communications

ASC-dependent inflammasomes contribute to immunopathology and mortality in herpes simplex encephalitis

(2021) Cooper K. Hayes et al.   PLoS Pathogens

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

(2021) Min Zheng et al.   NATURE IMMUNOLOGY

Cytokine Storm: The Primary Determinant for the Pathophysiological Evolution of COVID-19 Deterioration

(2021) Ruirong Chen et al.   Frontiers in Immunology

Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis

(2021) Heather Koehler et al.   Cell Host & Microbe

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

(2021) SangJoon Lee et al.   NATURE

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

(2021) Jerzy A. Woznicki et al.   Cell Death & Disease

Influenza Viruses: Innate Immunity and mRNA Vaccines

(2021) SangJoon Lee et al.   Frontiers in Immunology

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes

(2021) SangJoon Lee et al.   JCI Insight

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

Viral Z-RNA triggers ZBP1-dependent cell death

(2021) Siddharth Balachandran et al.   Current Opinion in Virology

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

The Science Underlying COVID-19: Implications for the Cardiovascular System

(2020) Peter P. Liu et al.   CIRCULATION

The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development

(2020) Sannula Kesavardhana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PB1‐F2 protein of highly pathogenic influenza A (H7N9) virus selectively suppresses RNA‐induced NLRP3 inflammasome activation through inhibition of MAVS‐NLRP3 interaction

(2020) Pak‐Hin Hinson Cheung et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

(2020) Matthew Hackbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)

(2020) Shelbi Christgen et al.   Frontiers in Cellular and Infection Microbiology

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

(2020) Min Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

The COVID-19 Cytokine Storm; What We Know So Far

(2020) Dina Ragab et al.   Frontiers in Immunology

SARS-Coronavirus-2 Nsp13 Possesses NTPase and RNA Helicase Activities That Can Be Inhibited by Bismuth Salts

(2020) Ting Shu et al.   VIROLOGICA SINICA

Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

(2020) SangJoon Lee et al.   TRENDS IN IMMUNOLOGY

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

(2020) Yoriyuki Konno et al.   Cell Reports

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

PANoptosis in microbial infection

(2020) David E Place et al.   CURRENT OPINION IN MICROBIOLOGY

ZBP1 mediates interferon-induced necroptosis

(2019) Daowei Yang et al.   Cellular & Molecular Immunology

Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC

(2019) Kam-Leung Siu et al.   FASEB JOURNAL

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1

(2019) Justin P. Ingram et al.   JOURNAL OF IMMUNOLOGY

Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved caspase-1 and IL-1β

(2019) Xiao-Qian Li et al.   NEUROPHARMACOLOGY

Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium

(2019) SangJoon Lee et al.   Science Immunology

Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity–independent pyroptosis, apoptosis, necroptosis, and inflammatory disease

(2019) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFN operates pyroptosis and necroptosis during multidrug-resistant A. baumannii infection

(2018) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection

(2018) Teneema Kuriakose et al.   JOURNAL OF IMMUNOLOGY

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

ZBP1: Innate Sensor Regulating Cell Death and Inflammation

(2018) Teneema Kuriakose et al.   TRENDS IN IMMUNOLOGY

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

(2018) Rachael Barry et al.   Nature Communications

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

(2018) Anukriti Mathur et al.   Nature Microbiology

ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death

(2017) Sannula Kesavardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

(2017) Heather Koehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermins: Effectors of Pyroptosis

(2017) Stephen B. Kovacs et al.   TRENDS IN CELL BIOLOGY

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells

(2016) Janne Tynell et al.   JOURNAL OF GENERAL VIROLOGY

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis

(2016) Prajwal Gurung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitric oxide-mediated apoptosis of neutrophils through caspase-8 and caspase-3-dependent mechanism

(2016) Megha Dubey et al.   Cell Death & Disease

Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses

(2016) Huib H. Rabouw et al.   PLoS Pathogens

Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

(2016) Chan-Ki Min et al.   Scientific Reports

Herpes Simplex Virus Suppresses Necroptosis in Human Cells

(2015) Hongyan Guo et al.   Cell Host & Microbe

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

(2015) Shinya Omoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

(2015) Hin Chu et al.   JOURNAL OF INFECTIOUS DISEASES

The inflammasome NLRP3 plays a protective role against a viral immunopathological lesion

(2015) Fernanda Gimenez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

High Secretion of Interferons by Human Plasmacytoid Dendritic Cells upon Recognition of Middle East Respiratory Syndrome Coronavirus

(2015) Vivian A. Scheuplein et al.   JOURNAL OF VIROLOGY

Influenza A Virus Panhandle Structure Is Directly Involved in RIG-I Activation and Interferon Induction

(2015) GuanQun Liu et al.   JOURNAL OF VIROLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF- B Activation via the DNA-Dependent Activator of IFN Regulatory Factors

(2014) W. J. Kaiser et al.   JOURNAL OF IMMUNOLOGY

SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome

(2014) Chong-Shan Shi et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling

(2013) Michaela Weber et al.   Cell Host & Microbe

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment

(2013) S. K. P. Lau et al.   JOURNAL OF GENERAL VIROLOGY

Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis

(2013) Jie Zhou et al.   JOURNAL OF INFECTIOUS DISEASES

DNA Sensing-Independent Inhibition of Herpes Simplex Virus 1 Replication by DAI/ZBP1

(2013) T. H. Pham et al.   JOURNAL OF VIROLOGY

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

(2013) Zhenyu Cai et al.   NATURE CELL BIOLOGY

DAI/ZBP1/DLM-1 Complexes with RIP3 to Mediate Virus-Induced Programmed Necrosis that Is Targeted by Murine Cytomegalovirus vIRA

(2012) Jason W. Upton et al.   Cell Host & Microbe

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

Severe Acute Respiratory Syndrome Coronavirus Protein nsp1 Is a Novel Eukaryotic Translation Inhibitor That Represses Multiple Steps of Translation Initiation

(2012) K. G. Lokugamage et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity

(2012) Bénédicte F. Py et al.   MOLECULAR CELL

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Cutting Edge: Proteolytic Inactivation of Poly(ADP-Ribose) Polymerase 1 by the Nlrp3 and Nlrc4 Inflammasomes

(2010) R. K. S. Malireddi et al.   JOURNAL OF IMMUNOLOGY

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferons and viral infections

(2009) Volker Fensterl et al.   BIOFACTORS

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-κB

(2009) Manuele Rebsamen et al.   EMBO REPORTS

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell Death

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

Molecular Determinants for Subcellular Localization of the Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame 3b Protein

(2009) E. C. Freundt et al.   JOURNAL OF VIROLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

(2008) Mohamed Lamkanfi et al.   MOLECULAR & CELLULAR PROTEOMICS

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE