Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium

Recent advances in inflammasome biology

(2018) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Eurasian Avian-Like Swine Influenza A Viruses Escape Human MxA Restriction through Distinct Mutations in Their Nucleoprotein

(2018) Dominik Dornfeld et al.   JOURNAL OF VIROLOGY

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein

(2017) Christoph M. Deeg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Influenza A viruses escape from MxA restriction at the expense of efficient nuclear vRNP import

(2016) Veronika Götz et al.   Scientific Reports

Respiratory epithelial cells orchestrate pulmonary innate immunity

(2015) Jeffrey A Whitsett et al.   NATURE IMMUNOLOGY

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA

(2014) David Riegger et al.   JOURNAL OF VIROLOGY

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

(2013) Han Xiao et al.   JOURNAL OF VIROLOGY

Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

(2013) J. Verhelst et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

(2013) Benjamin Mänz et al.   PLoS Pathogens

Structure of Myxovirus Resistance Protein A Reveals Intra- and Intermolecular Domain Interactions Required for the Antiviral Function

(2011) Song Gao et al.   IMMUNITY

Stalk Domain of the Dynamin-like MxA GTPase Protein Mediates Membrane Binding and Liposome Tubulation via the Unstructured L4 Loop

(2011) Alexander von der Malsburg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Expression of NLRP3 among Hematopoietic Cells

(2011) G. Guarda et al.   JOURNAL OF IMMUNOLOGY

The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses

(2011) P. Zimmermann et al.   JOURNAL OF VIROLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human MxA Protein: An Interferon-Induced Dynamin-Like GTPase with Broad Antiviral Activity

(2010) Otto Haller et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Structural basis of oligomerization in the stalk region of dynamin-like MxA

(2010) Song Gao et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Influenza virus activates inflammasomes via its intracellular M2 ion channel

(2010) Takeshi Ichinohe et al.   NATURE IMMUNOLOGY

Interferon-inducedSus scrofaMx1 blocks endocytic traffic of incoming influenza A virus particles

(2010) Mélanie Palm et al.   VETERINARY RESEARCH

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens