Biomimetic tumor microenvironment on a microfluidic platform

Quantitative Study of the Dynamic Tumor–Endothelial Cell Interactions through an Integrated Microfluidic Coculture System

(2012) Chunhong Zheng et al.   ANALYTICAL CHEMISTRY

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

(2012) Shawn P. Carey et al.   BIOMATERIALS

Growth factor signaling in metastasis: current understanding and future opportunities

(2012) Frank J. Lowery et al.   CANCER AND METASTASIS REVIEWS

Tumor microenvironment: a main actor in the metastasis process

(2012) Daniela Spano et al.   CLINICAL & EXPERIMENTAL METASTASIS

Probing the role of mesenchymal stem cells in salivary gland cancer on biomimetic microdevices

(2012) Huipeng Ma et al.   Integrative Biology

Anastomosis of endothelial sprouts forms new vessels in a tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   Integrative Biology

Breast tumour initiating cell fate is regulated by microenvironmental cues from an extracellular matrix

(2012) Sharmistha Saha et al.   Integrative Biology

A microfluidic-based device for study of transendothelial invasion of tumor aggregates in realtime

(2012) Qian Zhang et al.   LAB ON A CHIP

High Interstitial Fluid Pressure Is Associated with Tumor-Line Specific Vascular Abnormalities in Human Melanoma Xenografts

(2012) Trude G. Simonsen et al.   PLoS One

Independent regulation of tumor cell migration by matrix stiffness and confinement

(2012) A. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels

(2011) Tony Chen et al.   Biomechanics and Modeling in Mechanobiology

A microfluidic membrane device to mimic critical components of the vascular microenvironment

(2011) Suthan Srigunapalan et al.   Biomicrofluidics

Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

(2011) Ioannis K. Zervantonakis et al.   Biomicrofluidics

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Cell self-patterning on uniform PDMS-surfaces with controlled mechanical cues

(2011) Ilaria E. Palamà et al.   Integrative Biology

Migration dynamics of breast cancer cells in a tunable 3D interstitial flow chamber

(2011) Ulrike Haessler et al.   Integrative Biology

A computational study of bifunctional oxygen electrode in air-breathing reversible microfluidic fuel cells

(2011) Jin Xuan et al.   INTERNATIONAL JOURNAL OF HYDROGEN ENERGY

An in vitro correlation of metastatic capacity, substrate rigidity, and ECM composition

(2011) Indrajyoti Indra et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Integration of intra- and extravasation in one cell-based microfluidic chip for the study of cancer metastasis

(2011) Min Kyeong Shin et al.   LAB ON A CHIP

Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip

(2011) Tsi-Hsuan Hsu et al.   LAB ON A CHIP

Fabrication of Substrates with Defined Mechanical Properties and Topographical Features for the Study of Cell Migration

(2011) Jonathan M. Charest et al.   MACROMOLECULAR BIOSCIENCE

Cell-matrix adhesions in 3D

(2011) Jill S. Harunaga et al.   MATRIX BIOLOGY

Heparan Sulfate Proteoglycans Mediate Interstitial Flow Mechanotransduction Regulating MMP-13 Expression and Cell Motility via FAK-ERK in 3D Collagen

(2011) Zhong-Dong Shi et al.   PLoS One

Interstitial flow influences direction of tumor cell migration through competing mechanisms

(2011) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recreating the perivascular niche ex vivo using a microfluidic approach

(2010) Bita Carrion et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors

(2010) Christopher A Hamm et al.   BMC CANCER

Microfluidic gradient platforms for controlling cellular behavior

(2010) Bong Geun Chung et al.   ELECTROPHORESIS

Characterization of the interaction between fibroblasts and tumor cells on a microfluidic co-culture device

(2010) Huipeng Ma et al.   ELECTROPHORESIS

Hallmarks of cancer: Interactions with the tumor stroma

(2010) Kristian Pietras et al.   EXPERIMENTAL CELL RESEARCH

Determinants of leader cells in collective cell migration

(2010) Antoine A. Khalil et al.   Integrative Biology

Biological applications of microfluidic gradient devices

(2010) Sudong Kim et al.   Integrative Biology

Transition to invasion in breast cancer: a microfluidic in vitro model enables examination of spatial and temporal effects

(2010) Kyung Eun Sung et al.   Integrative Biology

An integrated microfluidic system for studying cell-microenvironmental interactions versatilely and dynamically

(2010) Wenming Liu et al.   LAB ON A CHIP

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Impact of Tumor Cell Cytoskeleton Organization on Invasiveness and Migration: A Microchannel-Based Approach

(2010) Claudio G. Rolli et al.   PLoS One

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

(2010) Robert W. Tilghman et al.   PLoS One

Optical Oxygen Sensors for Applications in Microfluidic Cell Culture

(2010) Samantha M. Grist et al.   SENSORS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix

(2009) Tingjiao Liu et al.   ELECTROPHORESIS

Cancer associated fibroblasts (CAFs) in tumor microenvironment

(2009) Fei Xing   Frontiers in Bioscience-Landmark

Spontaneous migration of cancer cells under conditions of mechanical confinement

(2009) Daniel Irimia et al.   Integrative Biology

Cellular observations enabled by microculture: paracrine signaling and population demographics

(2009) Maribella Domenech et al.   Integrative Biology

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

(2009) Carlos P. Huang et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

An in-vitro tumour microenvironment model using adhesion to type I collagen reveals Akt-dependent radiation resistance in renal cancer cells

(2009) Lina Krasny et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

(2009) Jonathan W. Song et al.   PLoS One

Microfluidic single-cell analysis of intracellular compounds

(2008) T.-C. Chao et al.   Journal of the Royal Society Interface

A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment

(2008) Vinay V. Abhyankar et al.   LAB ON A CHIP

Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates

(2008) Hirokazu Kaji et al.   LAB ON A CHIP

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Biomolecular gradients in cell culture systems

(2007) Thomas M. Keenan et al.   LAB ON A CHIP