Targeted Programming of the Lymph Node Environment Causes Evolution of Local and Systemic Immunity

Intrinsic immunogenicity of rapidly-degradable polymers evolves during degradation

(2016) James I. Andorko et al.   Acta Biomaterialia

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Neo approaches to cancer vaccines

(2015) L. Delamarre et al.   SCIENCE

Harnessing Biomaterials to Engineer the Lymph Node Microenvironment for Immunity or Tolerance

(2014) James I. Andorko et al.   AAPS Journal

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

(2014) Rajkumar Noubade et al.   NATURE

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

Rational design of small molecules as vaccine adjuvants

(2014) T. Y.- H. Wu et al.   Science Translational Medicine

Reprogramming antitumor immunity

(2014) Joseph G. Crompton et al.   TRENDS IN IMMUNOLOGY

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation

(2013) Janine K. Tom et al.   CHEMICAL COMMUNICATIONS

Blueprints of Signaling Interactions between Pattern Recognition Receptors: Implications for the Design of Vaccine Adjuvants

(2013) Kim Timmermans et al.   Clinical and Vaccine Immunology

Deciphering and Reversing Tumor Immune Suppression

(2013) Greg T. Motz et al.   IMMUNITY

Uncoupling T-cell expansion from effector differentiation in cell-based immunotherapy

(2013) Joseph G. Crompton et al.   IMMUNOLOGICAL REVIEWS

Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy?

(2013) Marianne Witten et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

(2013) A. de Titta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trial Watch

(2013) Erika Vacchelli et al.   OncoImmunology

Differential functional effects of biomaterials on dendritic cell maturation

(2012) Jaehyung Park et al.   Acta Biomaterialia

Characterizing the antitumor response in mice treated with antigen-loaded polyanhydride microparticles

(2012) Vijaya B. Joshi et al.   Acta Biomaterialia

Localized Mucosal Response to Intranasal Live Attenuated Influenza Vaccine in Adults

(2012) Maria Ines Barría et al.   JOURNAL OF INFECTIOUS DISEASES

Ten years of progress in vaccination against cancer: the need to counteract cancer evasion by dual targeting in future therapies

(2011) Yeranddy A. Alpizar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intra-Lymph Node Prime-Boost Vaccination against Melan A and Tyrosinase for the Treatment of Metastatic Melanoma: Results of a Phase 1 Clinical Trial

(2011) A. Ribas et al.   CLINICAL CANCER RESEARCH

Determinants of Successful CD8 + T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice

(2011) Christopher A. Klebanoff et al.   CLINICAL CANCER RESEARCH

Adjuvant effect of cationic liposomes and CpG depends on administration route

(2011) Bram Slütter et al.   JOURNAL OF CONTROLLED RELEASE

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

In situ engineering of the lymph node microenvironment via intranodal injection of adjuvant-releasing polymer particles

(2011) C. M. Jewell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation

(2010) Sachiko Hirosue et al.   VACCINE

Intralymphatic immunotherapy

(2009) Gabriela Senti et al.   Current Opinion in Allergy and Clinical Immunology

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

(2009) Fiona A. Sharp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen kinetics determines immune reactivity

(2008) Pål Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA