Propagative isatin in organic synthesis of spirooxindoles through catalysis

Synthesis, characterization and application of magnetic biochar sulfonic acid as a highly efficient recyclable catalyst for preparation of spiro-pyrazolo[3,4-b]pyridines

(2022) Li-Na Dong et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Novel cellulose supported 1,2-bis(4-aminophenylthio)ethane Ni(ii) complex (NiII(BAPTE)(NO3)2-Cell) as an efficient nanocatalyst for the synthesis of spirooxindole derivatives

(2022) Raziyeh Keshavarz et al.   RSC Advances

Synthesis and anti-Cancer Activity of a New Hybrid Based Spirooxindole-Pyrrolidine -Thiochromene Scaffolds via [3 + 2] Cycloaddition Reaction: Computational Investigation

(2022) Assem Barakat et al.   POLYCYCLIC AROMATIC COMPOUNDS

Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

(2021) Nilamuni H. de Silva et al.   BIOORGANIC CHEMISTRY

Design, green synthesis, antioxidant activity screening, and evaluation of protective effect on cerebral ischemia reperfusion injury of novel monoenone monocarbonyl curcumin analogs

(2021) Wenfei He et al.   BIOORGANIC CHEMISTRY

Regio- and stereoselective synthesis of spiro-heterocycles bearing the pyrazole scaffold via [3+2] cycloaddition reaction

(2021) Mohammad Shahidul Islam et al.   JOURNAL OF MOLECULAR STRUCTURE

Dispirooxindole-pyrrolothiazoles: Synthesis, anti-cancer activity, molecular docking and green chemistry metrics evaluation

(2021) Narayanasamy Nivetha et al.   JOURNAL OF MOLECULAR STRUCTURE

Design and characterization of Fe 3 O 4 /GO/Au‐Ag nanocomposite as an efficient catalyst for the green synthesis of spirooxindole‐dihydropyridines

(2020) Sara Kavyani et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Regioselectivity of (3+2) cycloaddition of azomethine ylides to activated olefins in the synthesis of spiro[oxindole-3,2′-pyrrolidine] derivatives

(2020) Alexei N. Izmest’ev et al.   Chemistry of Heterocyclic Compounds

Spirofused tetrahydroisoquinoline-oxindole hybrids as a novel class of fast acting antimalarial agents with multiple modes of action

(2020) Noella M. Efange et al.   Scientific Reports

Broad spectrum antimicrobial activity of dispirooxindolopyrrolidine fused acenaphthenone heterocyclic hybrid against healthcare associated microbial pathogens (HAMPs)

(2020) Abdulrahman I. Almansour et al.   Journal of Infection and Public Health

Advances in the Synthesis of Benzo‐Fused Spiro Nitrogen Heterocycles: New Approaches and Modification of Old Strategies

(2020) Rail R. Gataullin   HELVETICA CHIMICA ACTA

Kinetic Resolution of Tertiary Alcohols by Chiral DMAP Derivatives: Enantioselective Access to 3-Hydroxy-3-substituted 2-Oxindoles

(2020) Hiroki Mandai et al.   ORGANIC LETTERS

The application of isatin-based multicomponent-reactions in the quest for new bioactive and druglike molecules

(2020) Pedro Brandão et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Acoustic Droplet Ejection Enabled Automated Reaction Scouting

(2019) Yuanze Wang et al.   ACS Central Science

Synthesis of Spiropyrazolines via a Pseudo-Six Component Reaction

(2019) Atieh Rezvanian et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Green Fabrication of Cobalt NPs using Aqueous Extract of Antioxidant Rich Zingiber and Their Catalytic Applications for the Synthesis of Pyrano[2,3-c]pyrazoles

(2019) Robabeh Sabaghi Mianai et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Highly efficient and green approach for the synthesis of spirooxindole derivatives in the presence of novel Brønsted acidic ionic liquids incorporated in UiO‐66 nanocages

(2019) Boshra Mirhosseini‐Eshkevari et al.   APPLIED ORGANOMETALLIC CHEMISTRY

An efficiently and quickly synthesized NiO@g-C3N4 nanocomposite-catalyzed green synthesis of spirooxindole derivatives

(2019) Zahra Amini Moqadam et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Chameleon-Like Activating Nature of the Spirooxindole Group in Donor–Acceptor Cyclopropanes

(2019) Andrey A. Akaev et al.   ORGANIC LETTERS

Expression of miR-133a-5p and ROCK2 in Heart in Methamphetamine-Induced Rats and Intervention of Rhynchophylline

(2019) Yuting Zhou et al.   PHARMACOLOGY

Nine-step total synthesis of (−)-strychnofoline

(2018) Qingzhen Yu et al.   CHEMICAL COMMUNICATIONS

Microwave Assisted Synthesis of Spiro Heterocyclic Systems: A Review

(2018) Pankaj Khanna et al.   CURRENT ORGANIC CHEMISTRY

Synthesis, characterisation, and evaluation of core–shell Fe3O4/SiO2/polypyrrole composite nanoparticles

(2018) Bei Li et al.   Micro & Nano Letters

Combining C-H functionalisation and flow photochemical heterocyclic metamorphosis (FP-HM) for the synthesis of benzo[1,3]oxazepines

(2018) Jasraj S. Babra et al.   TETRAHEDRON

Regio- and diastereoselective synthesis of anticancer spirooxindoles derived from tryptophan and histidine via three-component 1,3-dipolar cycloadditions in an ionic liquid

(2018) Natarajan Arumugam et al.   TETRAHEDRON

Merging metathesis and photochemical Csp 3 -H activation: Access to masked β-formyl hexanolides and their rearrangement to furofuranones

(2018) Quentin Glenadel et al.   TETRAHEDRON

Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

(2018) Assem Barakat et al.   RSC Advances

A Novel Preyssler-Based Nanocomposite as a Magnetic Photocatalyst: Synthesis, Characterization and its Photocatalytic Activity for Decolirazation of Rodamine B

(2018) Fatemeh F. Bamoharram et al.   Micro & Nano Letters

Remote Control of Axial Chirality: Synthesis of Spirooxindole–Urazoles via Desymmetrization of ATAD

(2018) Lin-Lin Zhang et al.   ORGANIC LETTERS

Borax Catalysed Domino Synthesis of Highly Functionalised Spirooxindole and Chromenopyridine Derivatives: X-Ray Structure, Hirshfeld Surface Analysis and Molecular Docking Studies

(2018) Aniruddha Molla et al.   ChemistrySelect

One-pot synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors

(2018) Hany S Ibrahim et al.   Future Medicinal Chemistry

Iodine‐Catalyzed One‐Pot Four‐Component Synthesis of Spiro[indoline‐3,4′‐pyrano‐pyrazole] Derivatives

(2018) Atieh Rezvanian et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis of Spiro[indoline‐3,4′‐pyrano[3,2‐ c ]chromene]diones

(2018) Sakineh Ghadiri et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

γ‐Valerolactone as a Promising Bio‐Compatible Media for One‐Pot Synthesis of Spiro[indoline‐3,4'‐pyrano[3,2‐ c ]chromene Derivatives

(2018) Furqan Diwan et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Organocatalytic Asymmetric Synthesis of Spiro-Bridged and Spiro-Fused Heterocyclic Compounds Containing Chromane, Indole, and Oxindole Moieties

(2018) Zhi-Hao You et al.   ORGANIC LETTERS

IAA producing fungal endophyte Penicillium roqueforti Thom., enhances stress tolerance and nutrients uptake in wheat plants grown on heavy metal contaminated soils

(2018) Muhammad Ikram et al.   PLoS One

Utility of the Ditopic Nature of Magnetically Recyclable NiFe2 O4 Nano-Catalyst for the Green Synthesis of Two Different Spiro[indoline-pyrrolizine] Scaffolds

(2018) Soumyadip Basu et al.   ChemistrySelect

Potential role of lycopene in targeting proprotein convertase subtilisin/kexin type-9 to combat hypercholesterolemia

(2017) Sahir Sultan Alvi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats

(2017) Xin Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Synthesis and Antibacterial Evaluation of Novel Spiro[indole-pyrimidine]ones

(2017) Maryam Pourshab et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Spiro[4H -2,3-dihydropyran-3,3′-oxindoles] derived from 1,2,3,4-tetrahydroquinoline

(2017) Bahman Ebrahimi Saatluo et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2–p53 Interaction

(2017) Ming-Cheng Yang et al.   ORGANIC LETTERS

Novel visible-light driven Mn 0.8 Cd 0.2 S/g-C 3 N 4 composites: Preparation and efficient photocatalytic hydrogen production from water without noble metals

(2016) Hong Liu et al.   APPLIED CATALYSIS A-GENERAL

Gold catalyzed double condensation reaction: Synthesis, antimicrobial and cytotoxicity of spirooxindole derivatives

(2016) K. Parthasarathy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Three-component reaction for synthesis of functionalized spiro[indoline-3,4′-pyrano[3,2-h]quinolines]

(2016) Rong-Guo Shi et al.   CHINESE CHEMICAL LETTERS

Spiroindolone NITD609 is a novel antimalarial drug that targets the P-type ATPase PfATP4

(2016) Helen Turner   Future Medicinal Chemistry

Microwave Heated Flow Synthesis of Spiro-oxindole Dihydroquinazolinone Based IRAP Inhibitors

(2014) Karin Engen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Nano-ZnO Catalyzed Multicomponent One-Pot Synthesis of Novel Spiro(indoline-pyranodioxine) Derivatives

(2014) Harshita Sachdeva et al.   TheScientificWorldJOURNAL

Brønsted acidic ionic liquids: Green, efficient and reusable catalyst for synthesis of fluorinated spiro [indole-thiazinones/thiazolidinones] as antihistamic agents

(2012) Kapil Arya et al.   JOURNAL OF FLUORINE CHEMISTRY

Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer

(2008) Sanjeev Shangary et al.   MOLECULAR CANCER THERAPEUTICS