Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

Natural spirocyclic alkaloids and polyphenols as multi target dementia leads

(2021) Helmut M. Hügel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

(2020) Carolina S. Marques et al.   BIOORGANIC CHEMISTRY

Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes

(2020) Emmanuelle Lautié et al.   Frontiers in Pharmacology

Bioavailability enhancement of EGCG by structural modification and nano-delivery: A review

(2019) Wenzhong Dai et al.   Journal of Functional Foods

Recent advances in the neurobiology and neuropharmacology of Alzheimer’s disease

(2018) Kushal Kumar et al.   BIOMEDICINE & PHARMACOTHERAPY

Rhynchophylline suppresses soluble Aβ 1-42 -induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors

(2018) Yang Yang et al.   NEUROPHARMACOLOGY

In Search of an Identity for Amyloid Plaques

(2018) Tien-Phat V. Huynh et al.   TRENDS IN NEUROSCIENCES

Enhanced oral bioavailability of EGCG using pH-sensitive polymeric nanoparticles: characterization and in vivo investigation on nephrotic syndrome rats

(2018) Guojuan Zhang et al.   Drug Design Development and Therapy

Nitro-Group-Containing Drugs

(2018) Kunal Nepali et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

(2017) Reisuke H. Takahashi et al.   PATHOLOGY INTERNATIONAL

Oxidized epigallocatechin gallate inhibited lysozyme fibrillation more strongly than the native form

(2017) Ting-Ting An et al.   Redox Biology

Certain (−)-epigallocatechin-3-gallate (EGCG) auto-oxidation products (EAOPs) retain the cytotoxic activities of EGCG

(2016) Yaqing Wei et al.   FOOD CHEMISTRY

Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

(2016) Andreas Gollner et al.   JOURNAL OF MEDICINAL CHEMISTRY

A convenient and rapid microwave-assisted synthesis of spirooxindoles in aqueous medium and their antimicrobial activities

(2016) Prakash R. Mali et al.   NEW JOURNAL OF CHEMISTRY

Spiroindole Alkaloids and Spiroditerpenoids from Aspergillus duricaulis and Their Potential Neuroprotective Effects

(2015) Jaeyoung Kwon et al.   JOURNAL OF NATURAL PRODUCTS

Polyphenols for the prevention and treatment of dementia diseases

(2015) HelmutM Hügel et al.   Neural Regeneration Research

Rhynchophylline Protects Against the Amyloid β-Induced Increase of Spontaneous Discharges in the Hippocampal CA1 Region of Rats

(2015) Hui Shao et al.   NEUROCHEMICAL RESEARCH

Determination of protein-unbound rhynchiphylline brain distribution by microdialysis and ultra-performance liquid chromatography with tandem mass spectrometry

(2014) Chia-Jung Lee et al.   BIOMEDICAL CHROMATOGRAPHY

What does the aromatic ring number mean for drug design?

(2014) Simon E Ward et al.   Expert Opinion on Drug Discovery

A brief overview of amyloids and Alzheimer's disease

(2014) Sian-Yang Ow et al.   PROTEIN SCIENCE

A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole–pyrrolizine–piperidine hybrids

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Regio- and stereoselective synthesis of spirooxindole 1′-nitro pyrrolizidines with five concurrent stereocenters under aqueous medium and their bioprospection using the zebrafish (Danio rerio) embryo model

(2013) Carlos E. Puerto Galvis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Enantioselective synthesis of the spirotryprostatin A scaffold

(2011) Andrey P. Antonchick et al.   TETRAHEDRON

Antimycobacterial activity of spirooxindolo-pyrrolidine, pyrrolizine and pyrrolothiazole hybrids obtained by a three-component regio- and stereoselective 1,3-dipolar cycloaddition

(2011) Stephen Michael Rajesh et al.   MedChemComm

Antihypertensive and neuroprotective activities of rhynchophylline: The role of rhynchophylline in neurotransmission and ion channel activity

(2010) Jiyin Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Safety and Tolerability of Donepezil, Rivastigmine and Galantamine for Patients with Alzheimer’s Disease: Systematic Review of the ‘Real-World’ Evidence

(2009) I.A. Lockhart et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’

(2009) Fernando de Sa Alves et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

(2008) Govindasami Periyasami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

On the binding of Thioflavin-T to HET-s amyloid fibrils assembled at pH 2

(2008) Raimon Sabaté et al.   JOURNAL OF STRUCTURAL BIOLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY