Synthesis and anti-Cancer Activity of a New Hybrid Based Spirooxindole-Pyrrolidine -Thiochromene Scaffolds via [3 + 2] Cycloaddition Reaction: Computational Investigation

Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds

(2021) Shima Nasri et al.   Topics in Current Chemistry

Microwave-assisted rapid synthesis of spirooxindole-pyrrolizidine analogues and their activity as anti-amyloidogenic agents

(2021) Nilamuni H. de Silva et al.   BIOORGANIC CHEMISTRY

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes

(2021) Vojtěch Dočekal et al.   JOURNAL OF ORGANIC CHEMISTRY

Regio- and Stereoselective Synthesis of a New Series of Spirooxindole Pyrrolidine Grafted Thiochromene Scaffolds as Potential Anticancer Agents

(2021) Assem Barakat et al.   Symmetry-Basel

Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators

(2021) Gehad Lotfy et al.   BIOORGANIC CHEMISTRY

Dispirooxindole-pyrrolothiazoles: Synthesis, anti-cancer activity, molecular docking and green chemistry metrics evaluation

(2021) Narayanasamy Nivetha et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel preparation of chiral 3,2′-pyrrolidinyl spirooxindole from an enantioselective Michael addition between 3-(diphenylmethylene)-amino-oxindole and acrolein catalyzed by a cinchona alkaloid

(2021) Zhi-Cheng Huang et al.   TETRAHEDRON LETTERS

Diastereodivergent synthesis of fully disubstituted spiro[indoline-3,2′-pyrrolidin]-2-ones via tuneable Lewis base/Brønsted base-promoted (3 + 2) cycloadditions

(2021) Ke Li et al.   Organic Chemistry Frontiers

Efficient enantioselective synthesis of CF2H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s via organocatalytic cycloaddition

(2021) Yabo Deng et al.   Organic Chemistry Frontiers

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation

(2021) Yasmine M. Abdel Aziz et al.   Frontiers in Chemistry

Unveiling the Reactivity of Cyclic Azomethine Ylides in [3+2] Cycloaddition Reactions within the Molecular Electron Density Theory

(2020) Luis R. Domingo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

In the triple-negative breast cancer MDA-MB-231 cell line, sulforaphane enhances the intracellular accumulation and anticancer action of doxorubicin encapsulated in liposomes

(2019) Lidia Mielczarek et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Molecular structure, Hirshfeld surface analysis, spectroscopic (FT-IR, Laser-Raman, UV–vis. and NMR), HOMO-LUMO and NBO investigations on N -(12-amino-9,10-dihydro-9,10-ethanoanthracen-11-yl)-4-methylbenzenesulfonamide

(2018) Can Alaşalvar et al.   JOURNAL OF MOLECULAR STRUCTURE

Molecular docking, Hirshfeld surface, structural, spectroscopic, electronic, NLO and thermodynamic analyses on novel hybrid compounds containing pyrazole and coumarin cores

(2018) Yusuf Sert et al.   JOURNAL OF MOLECULAR STRUCTURE

Unravelling the Mysteries of [3+2] Cycloaddition Reactions

(2018) Mar Ríos-Gutiérez et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Applications of the Conceptual Density Functional Theory Indices to Organic Chemistry Reactivity

(2016) Luis Domingo et al.   MOLECULES

Molecular Electron Density Theory: A Modern View of Reactivity in Organic Chemistry

(2016) Luis Domingo   MOLECULES

Synthesis and biological evaluation of 3-phenyl-3-aryl carboxamido propanoic acid derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26A1)

(2015) Dongmei Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular diversity of spirooxindoles. Synthesis and biological activity

(2015) Tetyana L. Pavlovska et al.   MOLECULAR DIVERSITY

A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

(2015) Abdulrahman Almansour et al.   MOLECULES

A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies

(2015) Saoussen Haddad et al.   NEW JOURNAL OF CHEMISTRY

SHELXT– Integrated space-group and crystal-structure determination

(2015) George M. Sheldrick   Acta Crystallographica A-Foundation and Advances

Crystal structure refinement withSHELXL

(2015) George M. Sheldrick   Acta Crystallographica Section C-Structural Chemistry

Novel spirooxindole–pyrrolidine compounds: Synthesis, anticancer and molecular docking studies

(2014) Y. Arun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel dispiropyrrolothiazoles by three-component 1,3-dipolar cycloaddition and evaluation of their antimycobacterial activity

(2014) Saoussen Haddad et al.   RSC Advances

A new C–C bond formation model based on the quantum chemical topology of electron density

(2014) Luis R. Domingo   RSC Advances

Understanding the local reactivity in polar organic reactions through electrophilic and nucleophilic Parr functions

(2012) Luis R. Domingo et al.   RSC Advances

ShelXle: a Qt graphical user interface forSHELXL

(2011) Christian B. Hübschle et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Total synthesis of (±)-coerulescine and (±)-horsfiline

(2010) Mukund G Kulkarni et al.   Beilstein Journal of Organic Chemistry

Understanding the High Reactivity of the Azomethine Ylides in [3 + 2] Cycloaddition Reactions

(2010) Luis R. Domingo et al.   LETTERS IN ORGANIC CHEMISTRY

Understanding the Reactivity of Captodative Ethylenes in Polar Cycloaddition Reactions. A Theoretical Study†

(2008) Luis R. Domingo et al.   JOURNAL OF ORGANIC CHEMISTRY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA