One-pot synthesis of spiro(indoline-3,4′-pyrazolo[3,4-b]pyridine)-5′-carbonitriles as p53-MDM2 interaction inhibitors

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation

(2018) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards colon cancer

(2018) Wagdy M. Eldehna et al.   BIOORGANIC CHEMISTRY

One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells

(2017) Wagdy M. Eldehna et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Three-Component Synthesis of Spiro[indoline-3,4′-pyrazolo[3,4-b ]pyridines] under Microwave Irradiation

(2017) Xia Gao et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Natural Product-Derived Spirooxindole Fragments Serve as Privileged Substructures for Discovery of New Anticancer Agents

(2016) Bin Yu et al.   Anti-Cancer Agents in Medicinal Chemistry

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives

(2016) Wagdy M. Eldehna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation

(2016) Sahar M. Abou-Seri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Review of synthesis and various biological activities of spiro heterocyclic compounds comprising oxindole and pyrrolidine moities

(2016) Pankaj Saraswat et al.   SYNTHETIC COMMUNICATIONS

Therapeutic Potential of Spirooxindoles as Antiviral Agents

(2016) Na Ye et al.   ACS Infectious Diseases

SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma

(2015) K. L. J. Bill et al.   CLINICAL CANCER RESEARCH

Spirooxindoles: Promising scaffolds for anticancer agents

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular diversity of spirooxindoles. Synthesis and biological activity

(2015) Tetyana L. Pavlovska et al.   MOLECULAR DIVERSITY

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy

(2014) Zhuming Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The use of spirocyclic scaffolds in drug discovery

(2014) Yajun Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Abstract LB-204: Highly potent and optimized small-molecule inhibitors of MDM2 achieve complete tumor regression in animal models of solid tumors and leukemia.

(2014) S. Wang et al.   CANCER RESEARCH

Phosphine-catalyzed asymmetric [4+1] annulation of activated α,β-unsaturated ketones with Morita–Baylis–Hillman carbonates: enantioselective synthesis of spirooxindoles containing two adjacent quaternary stereocenters

(2014) Fang-Le Hu et al.   CHEMICAL COMMUNICATIONS

Small-Molecule Inhibitors of the MDM2–p53 Protein–Protein Interaction (MDM2 Inhibitors) in Clinical Trials for Cancer Treatment

(2014) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Chemically Stable, Potent, and Efficacious MDM2 Inhibitors That Exploit the Retro-Mannich Ring-Opening-Cyclization Reaction Mechanism in Spiro-oxindoles

(2014) Angelo Aguilar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

(2010) Grzegorz M. Popowicz et al.   CELL CYCLE

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

When analoging is not enough: scaffold discovery in medicinal chemistry

(2010) Hongyu Zhao et al.   Expert Opinion on Drug Discovery

Novel, One-Pot, Three-Component Route to Indol-3-yl Substituted Spirooxindole Derivatives

(2010) Tao Chen et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

An efficient one-pot synthesis of N-(1,3-diphenyl-1H-pyrazol- 5-yl)amides

(2010) Wei-Nien Su et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

(2009) Ikyon Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-molecule inhibitors of MDM2 as new anticancer therapeutics

(2009) Michael P. Dickens et al.   SEMINARS IN CANCER BIOLOGY