Design, green synthesis, antioxidant activity screening, and evaluation of protective effect on cerebral ischemia reperfusion injury of novel monoenone monocarbonyl curcumin analogs

Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification

(2020) Jun Wan Shin et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats

(2020) Lujing Wang et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Curcumin analog A13 alleviates oxidative stress by activating Nrf2/ARE pathway and ameliorates fibrosis in the myocardium of high-fat-diet and streptozotocin-induced diabetic rats

(2020) Lanting Xiang et al.   Diabetology & Metabolic Syndrome

Resolving Binding Events on the Multifunctional Human Serum Albumin

(2020) Lea Wenskowsky et al.   ChemMedChem

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

(2019) Jiabing Wang et al.   Acta Pharmaceutica Sinica B

Clinical Effects of Early Edaravone Use in Acute Ischemic Stroke Patients Treated by Endovascular Reperfusion Therapy

(2019) Masaya Enomoto et al.   STROKE

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –

(2019) Ting Mei et al.   BIOMATERIALS

Curcumin analogues attenuate Aβ25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways

(2019) Jialin Xu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Association between urban green space and the risk of cardiovascular disease: A longitudinal study in seven Korean metropolitan areas

(2019) Sumin Seo et al.   ENVIRONMENT INTERNATIONAL

Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI)

(2019) Jianchang Qian et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

(2019) Senna Staessens et al.   HAEMATOLOGICA

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

(2019) Henry Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Role of a Cysteine Precursor, OTC, in Ischemic Stroke Is Mediated by Improved Proteostasis in Mice

(2019) Yanying Liu et al.   Translational Stroke Research

Antioxidant and anti‐inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline‐induced right ventricular hypertrophy

(2019) Nikola Hadzi‐Petrushev et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart

(2019) Pallavi Mishra et al.   Scientific Reports

Design, Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-reperfusion Injury

(2019) Ge Li et al.   ACS Chemical Neuroscience

Sequential Two‐Step Stereoselective Amination of Allylic Alcohols through Combination of Laccases and Amine Transaminases

(2019) Jesús Albarrán-Velo et al.   CHEMBIOCHEM

Intrathecal Administration of Nanoclusters for Protecting Neurons against Oxidative Stress in Cerebral Ischemia/Reperfusion Injury

(2019) Shiyong Li et al.   ACS Nano

Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury

(2019) Milad Ashrafizadeh et al.   CURRENT MOLECULAR MEDICINE

A short review on chemical properties, stability and nano-technological advances for curcumin delivery

(2019) Layal Slika et al.   Expert Opinion on Drug Delivery

Inhibition Of JNK Phosphorylation By Curcumin Analog C66 Protects LPS-Induced Acute Lung Injury

(2019) Zhongxiang Xiao et al.   Drug Design Development and Therapy

Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-κB pathway inhibition

(2018) Liping Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and evaluation of NDGA analogues as potential anti-ischemic stroke agents

(2018) Lili Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and QSAR study of novel isatin analogues inspired Michael acceptor as potential anticancer compounds

(2018) Jiabing Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Steroid-Type Antioxidant Targeting the Keap1/Nrf2/ARE Signaling Pathway from the Soft Coral Dendronephthya gigantea

(2018) Jianzhang Wu et al.   JOURNAL OF NATURAL PRODUCTS

An access to α, β-unsaturated ketones via dual cooperative catalysis

(2018) Lakshmi V.R. Babu Syamala et al.   TETRAHEDRON LETTERS

Synthesis and evaluation of asymmetric curcuminoid analogs as potential anticancer agents that downregulate NF-κB activation and enhance the sensitivity of gastric cancer cell lines to irinotecan chemotherapy

(2017) Peihong Qiu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The potential of natural products for targeting PPAR α

(2017) Daniela Rigano et al.   Acta Pharmaceutica Sinica B

The modification of natural products for medical use

(2017) Zongru Guo   Acta Pharmaceutica Sinica B

Bringing Curcumin to the Clinic in Cancer Prevention: a Review of Strategies to Enhance Bioavailability and Efficacy

(2016) Rama I. Mahran et al.   AAPS Journal

Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of α,β-Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols

(2016) Venkati Bethi et al.   JOURNAL OF ORGANIC CHEMISTRY

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents

(2016) Girish A. Hampannavar et al.   ACS Medicinal Chemistry Letters

Promotion of behavior and neuronal function by reactive oxygen species in C. elegans

(2016) Guang Li et al.   Nature Communications

Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention

(2015) Yan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis, cytotoxicity against human oral cancer KB cells and structure–activity relationship studies of trienone analogues of curcuminoids

(2014) Thipphawan Chuprajob et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents

(2013) Jianzhang Wu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Palladium-Catalyzed Decarboxylative Arylation of Benzoylacrylic Acids toward the Synthesis of Chalcones

(2013) Yuto Unoh et al.   JOURNAL OF ORGANIC CHEMISTRY

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

(2013) Esther Parada et al.   JOURNAL OF PINEAL RESEARCH

Synthesis of 3,5-Disubstituted Cyclohex-2-en-1-one via a Five-Step Domino Reaction Catalyzed by Secondary Amines: Formation of (E)-α,β-Unsaturated Methyl Ketones

(2013) Manas K. Ghorai et al.   Asian Journal of Organic Chemistry

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

(2012) Romeo Romagnoli et al.   Letters in Drug Design & Discovery

Evaluation and Discovery of Novel Synthetic Chalcone Derivatives as Anti-Inflammatory Agents

(2011) Jianzhang Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-Pressure Diels−Alder Cycloadditions between Benzylideneacetones and 1,3-Butadienes: Application to the Synthesis of (R,R)-(−)- and (S,S)-(+)-Δ8-Tetrahydrocannabinol

(2010) Eleonora Ballerini et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure–activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof

(2009) Hiroyuki Yamakoshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY