Dispirooxindole-pyrrolothiazoles: Synthesis, anti-cancer activity, molecular docking and green chemistry metrics evaluation

Regio- and stereoselective synthesis of new spirooxindoles via 1,3-dipolar cycloaddition reaction: Anticancer and molecular docking studies

(2018) Gehad Lotfy et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

(2016) Andreas Gollner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole againstCandida albicans

(2015) Ilandari Dewage Udara Anulal Premachandra et al.   ChemMedChem

Molecular diversity of spirooxindoles. Synthesis and biological activity

(2015) Tetyana L. Pavlovska et al.   MOLECULAR DIVERSITY

Rational design, synthesis and molecular modeling studies of novel anti-oncological alkaloids against melanoma

(2015) Adel S. Girgis et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent advances in the synthesis of biologically active spirooxindoles

(2014) Maria M.M. Santos   TETRAHEDRON

Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors

(2013) Yalda Kia et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

(2013) Yujun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Diastereomeric Spirooxindoles as Highly Potent and Efficacious MDM2 Inhibitors

(2013) Yujun Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molar Efficiency: A Useful Metric To Gauge Relative Reaction Efficiency in Discovery Medicinal Chemistry

(2013) Fiona I. McGonagle et al.   ACS Sustainable Chemistry & Engineering

Ultrasound-promoted regioselective and stereoselective synthesis of novel spiroindanedionepyrrolizidines by multicomponent 1,3-dipolar cycloaddition of azomethine ylides

(2012) Elangovann Chandralekha et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Ultrasound promoted one-pot synthesis of 2-amino-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile scaffolds in aqueous media: A complementary ‘green chemistry’ tool to organic synthesis

(2012) Sayed Hossein Banitaba et al.   ULTRASONICS SONOCHEMISTRY

Contributions of organic electrosynthesis to green chemistry

(2011) Hans J. Schäfer   COMPTES RENDUS CHIMIE

An efficient one-pot three-component reaction for synthesis of spirooxindole derivatives in water media under catalyst-free condition

(2011) Li-Qin Zhao et al.   HETEROATOM CHEMISTRY

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Regiospecific synthesis and biological evaluation of spirooxindolopyrrolizidines via [3+2] cycloaddition of azomethine ylide

(2010) Arumugam Thangamani   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

(2010) Alessia Millemaggi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

(2010) Bryan K. S. Yeung et al.   JOURNAL OF MEDICINAL CHEMISTRY

A facile synthesis and antimycobacterial evaluation of novel spiro-pyrido-pyrrolizines and pyrrolidines

(2009) Raju Ranjith Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vivo antidiabetic activity of novel dispiropyrrolidines through [3+2] cycloaddition reactions with thiazolidinedione and rhodanine derivatives

(2009) Ramalingam Murugan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel three-component domino reactions of ketones, isatin and amino acids: Synthesis and discovery of antimycobacterial activity of highly functionalised novel dispiropyrrolidines

(2009) Raju Suresh Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a New Class of Potent, Selective, and Orally Bioavailable CRTH2 (DP2) Receptor Antagonists for the Treatment of Allergic Inflammatory Diseases#

(2008) Stefano Crosignani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Antimycobacterial Spiro-piperidin-4-ones: An Atom Economic, Stereoselective Synthesis, and Biological Intervention

(2008) Raju Ranjith Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY