The neuroscience of cancer

Glioblastoma remodelling of human neural circuits decreases survival

(2023) Saritha Krishna et al.   NATURE

Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression

(2022) De Huang et al.   NATURE CELL BIOLOGY

Brain motor and fear circuits regulate leukocytes during acute stress

(2022) Wolfram C. Poller et al.   NATURE

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

(2022) Pengxiang Chen et al.   NATURE

Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1

(2022) Corina Anastasaki et al.   Nature Communications

Glioma progression is shaped by genetic evolution and microenvironment interactions

(2022) Frederick S. Varn et al.   CELL

Glioblastoma hijacks neuronal mechanisms for brain invasion

(2022) Varun Venkataramani et al.   CELL

Nociceptor neurons affect cancer immunosurveillance

(2022) Mohammad Balood et al.   NATURE

Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies

(2022) Yu Zhang et al.   Cell Metabolism

Autonomous rhythmic activity in glioma networks drives brain tumour growth

(2022) David Hausmann et al.   NATURE

The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

(2022) Ilon Liu et al.   NATURE GENETICS

K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

(2022) Selin Jessa et al.   NATURE GENETICS

Adrenergic regulation of the vasculature impairs leukocyte interstitial migration and suppresses immune responses

(2021) Sapna Devi et al.   IMMUNITY

Microenvironmental interactions of oligodendroglial cells

(2021) Belgin Yalçın et al.   DEVELOPMENTAL CELL

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

(2021) Yuan Pan et al.   NATURE

Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models

(2021) Marcel André Schneider et al.   Science Translational Medicine

Insular cortex neurons encode and retrieve specific immune responses

(2021) Tamar Koren et al.   CELL

B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity

(2021) Baihao Zhang et al.   NATURE

Postoperative oscillatory brain activity as an add-on prognostic marker in diffuse glioma

(2020) Vera Belgers et al.   JOURNAL OF NEURO-ONCOLOGY

Activity Shapes Neural Circuit Form and Function: A Historical Perspective

(2020) Yuan Pan et al.   JOURNAL OF NEUROSCIENCE

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

(2020) Kwanha Yu et al.   NATURE

Preservation of a remote fear memory requires new myelin formation

(2020) Simon Pan et al.   NATURE NEUROSCIENCE

Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model

(2020) Asante Hatcher et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-dependent myelination: A glial mechanism of oscillatory self-organization in large-scale brain networks

(2020) Rabiya Noori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth

(2020) Xiaofan Guo et al.   Nature Communications

Cell Lineage-Based Stratification for Glioblastoma

(2020) Zilai Wang et al.   CANCER CELL

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

(2020) Siyi Huang et al.   CELL

GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner

(2019) Shu-Heng Jiang et al.   GUT

Progenitors from the central nervous system drive neurogenesis in cancer

(2019) Philippe Mauffrey et al.   NATURE

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment

(2019) Anna C. Geraghty et al.   NEURON

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

(2019) Cyril Neftel et al.   CELL

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

(2019) Atsunori Kamiya et al.   NATURE NEUROSCIENCE

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation

(2019) G. A. Weiner et al.   Nature Communications

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

Stress–glucocorticoid–TSC22D3 axis compromises therapy-induced antitumor immunity

(2019) Heng Yang et al.   NATURE MEDICINE

Pre-operative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a Phase II randomized trial

(2019) Jonathan G Hiller et al.   CLINICAL CANCER RESEARCH

Paralytic, the Drosophila voltage-gated sodium channel, regulates proliferation of neural progenitors

(2019) Beverly J. Piggott et al.   GENES & DEVELOPMENT

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

(2019) Hemn Mohammadpour et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Monosynaptic tracing maps brain-wide afferent oligodendrocyte precursor cell connectivity

(2019) Christopher W Mount et al.   eLife

Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State

(2019) Surya Nagaraja et al.   MOLECULAR CELL

Seizures and Tumor Progression in Glioma Patients with Uncontrollable Epilepsy Treated with Perampanel

(2018) SHUICHI IZUMOTO et al.   ANTICANCER RESEARCH

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Athymic mice reveal a requirement for T-cell–microglia interactions in establishing a microenvironment supportive ofNf1low-grade glioma growth

(2018) Yuan Pan et al.   GENES & DEVELOPMENT

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

(2018) Ethan G. Hughes et al.   NATURE NEUROSCIENCE

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

(2018) Robert A. Hill et al.   NATURE NEUROSCIENCE

Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

(2018) Chiaki Ohtaka-Maruyama et al.   SCIENCE

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

(2018) Mariella G. Filbin et al.   SCIENCE

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

(2018) Stanislaw Mitew et al.   Nature Communications

Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response

(2018) Guanxi Qiao et al.   Frontiers in Immunology

Oscillatory brain activity associates with neuroligin-3 expression and predicts progression free survival in patients with diffuse glioma

(2018) Jolanda Derks et al.   JOURNAL OF NEURO-ONCOLOGY

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies

(2017) G David Batty et al.   BMJ-British Medical Journal

Psychological distress in relation to site specific cancer mortality: pooling of unpublished data from 16 prospective cohort studies

(2017) G David Batty et al.   BMJ-British Medical Journal

Signalling through AMPA receptors on oligodendrocyte precursors promotes myelination by enhancing oligodendrocyte survival

(2017) Eleni Kougioumtzidou et al.   eLife

Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells

(2017) Maki Kotaka et al.   Scientific Reports

Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer

(2016) Mercedes J. Szpunar et al.   BRAIN BEHAVIOR AND IMMUNITY

Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes

(2016) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes

(2015) Sheila R. Alcantara Llaguno et al.   CANCER CELL

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

(2015) Shelby C. Peterson et al.   Cell Stem Cell

Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer

(2015) Jay Pundavela et al.   Molecular Oncology

Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission

(2014) Danielle V Bower et al.   BMC BIOLOGY

Chronic stress accelerates pancreatic cancer growth and invasion: A critical role for beta-adrenergic signaling in the pancreatic microenvironment

(2014) Corina Kim-Fuchs et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

(2014) Rachelle E. Stopczynski et al.   CANCER RESEARCH

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Parasympathetic Innervation Regulates Tubulogenesis in the Developing Salivary Gland

(2014) Pavel I. Nedvetsky et al.   DEVELOPMENTAL CELL

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

(2014) Susan L. Campbell et al.   GLIA

Nerve Fibers in Breast Cancer Tissues Indicate Aggressive Tumor Progression

(2014) Di Huang et al.   MEDICINE

Identification of distinct ChAT+ neurons and activity-dependent control of postnatal SVZ neurogenesis

(2014) Patricia Paez-Gonzalez et al.   NATURE NEUROSCIENCE

Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multistep reactivation process

(2014) Rui Pedro Galvao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Denervation suppresses gastric tumorigenesis

(2014) C.-M. Zhao et al.   Science Translational Medicine

Non-canonical functions of the peripheral nerve

(2013) Markéta Kaucká et al.   EXPERIMENTAL CELL RESEARCH

Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cell Proliferation

(2013) A. W. Wong et al.   JOURNAL OF NEUROSCIENCE

Interaction of the Sympathetic Nerve with Pancreatic Cancer Cells Promotes Perineural Invasion through the Activation of STAT3 Signaling

(2013) K. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

(2013) Lowry A. Kirkby et al.   NEURON

Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling

(2013) Kaylene M. Young et al.   NEURON

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Characterization of the autonomic innervation of mammary gland in lactating rats studied by retrograde transynaptic virus labeling and immunohistochemistry

(2012) Katalin Köves et al.   ACTA PHYSIOLOGICA HUNGARICA

Human glioma cells induce hyperexcitability in cortical networks

(2012) Susan L. Campbell et al.   EPILEPSIA

Neuronal Serotonin Regulates Growth of the Intestinal Mucosa in Mice

(2012) Erica R. Gross et al.   GASTROENTEROLOGY

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Sexually Dimorphic BDNF Signaling Directs Sensory Innervation of the Mammary Gland

(2012) Y. Liu et al.   SCIENCE

Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes

(2011) Daniel Albo et al.   CANCER

Pancreatitis-Induced Inflammation Contributes to Pancreatic Cancer by Inhibiting Oncogene-Induced Senescence

(2011) Carmen Guerra et al.   CANCER CELL

Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice

(2011) J.-P. Raufman et al.   CARCINOGENESIS

Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma

(2011) Chong Liu et al.   CELL

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Diffusion tensor imaging of white matter tract evolution over the lifespan

(2011) C. Lebel et al.   NEUROIMAGE

Intestinal Epithelial Stem/Progenitor Cells Are Controlled by Mucosal Afferent Nerves

(2011) Ove Lundgren et al.   PLoS One

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma

(2011) M. Monje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NF-κB and AP-1

(2010) Dong Zhang et al.   CANCER BIOLOGY & THERAPY

The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer

(2010) E. K. Sloan et al.   CANCER RESEARCH

NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network

(2010) Jean-Claude Platel et al.   NEURON

Parasympathetic Innervation Maintains Epithelial Progenitor Cells During Salivary Organogenesis

(2010) S. M. Knox et al.   SCIENCE

Gap junctions are involved in cell migration in the early postnatal subventricular zone

(2009) Mônica Marins et al.   Developmental Neurobiology

Perineural Invasion Is an Independent Predictor of Outcome in Colorectal Cancer

(2009) Catherine Liebig et al.   JOURNAL OF CLINICAL ONCOLOGY

Traveling waves in developing cerebellar cortex mediated by asymmetrical Purkinje cell connectivity

(2009) Alanna J Watt et al.   NATURE NEUROSCIENCE

Mechanisms underlying spontaneous patterned activity in developing neural circuits

(2009) Aaron G. Blankenship et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF

(2009) G. C. O'Keeffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Ablation of M3 Muscarinic Receptors Attenuates Murine Colon Epithelial Cell Proliferation and Neoplasia

(2008) J.-P. Raufman et al.   CANCER RESEARCH

Distribution and neurochemical identification of pancreatic afferents in the mouse

(2008) Kenneth E. Fasanella et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE