Attenuation of peripheral serotonin inhibits tumor growth and enhances immune checkpoint blockade therapy in murine tumor models

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

(2019) Lorna A. Farrelly et al.   NATURE

Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance

(2019) Daisuke Muraoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial

(2018) Marianne Pavel et al.   ENDOCRINE-RELATED CANCER

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

(2018) Mirjana Efremova et al.   Nature Communications

Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas

(2018) Enrica Saponara et al.   JOURNAL OF PATHOLOGY

Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin

(2018) Marcel André Schneider et al.   ANNALS OF SURGERY

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

(2017) Shu-Heng Jiang et al.   GASTROENTEROLOGY

Telotristat Ethyl, a Tryptophan Hydroxylase Inhibitor for the Treatment of Carcinoid Syndrome

(2017) Matthew H. Kulke et al.   JOURNAL OF CLINICAL ONCOLOGY

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective portal vein injection for the design of syngeneic models of liver malignancy

(2016) Perparim Limani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

What does PD-L1 positive or negative mean?

(2016) Antoni Ribas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

Serotonin transporter antagonists target tumor-initiating cells in a transgenic mouse model of breast cancer

(2016) Robin M. Hallett et al.   Oncotarget

Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery

(2016) Suzanne I.S. Mosely et al.   Cancer Immunology Research

Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results

(2015) Mumtahena Rahman et al.   BIOINFORMATICS

Serotonin and Cancer: What Is the Link?

(2015) D. Sarrouilhe et al.   CURRENT MOLECULAR MEDICINE

Releasing the Brakes on Cancer Immunotherapy

(2015) Antoni Ribas   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of serotonin and its receptors in activation of immune responses and inflammation

(2014) M. S. Shajib et al.   Acta Physiologica

Platelets and cancer: a casual or causal relationship: revisited

(2014) David G. Menter et al.   CANCER AND METASTASIS REVIEWS

Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice

(2014) Christian E. Oberkofler et al.   HEPATOLOGY

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

Acute Fluoxetine Treatment Induces Slow Rolling of Leukocytes on Endothelium in Mice

(2014) Nadine Herr et al.   PLoS One

Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine

(2013) Kara Gross Margolis et al.   GUT

Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection

(2013) Johannes vom Berg et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

(2013) M. de las Casas-Engel et al.   JOURNAL OF IMMUNOLOGY

Immunogenicity of Murine Solid Tumor Models as a Defining Feature of In Vivo Behavior and Response to Immunotherapy

(2013) Melissa G. Lechner et al.   JOURNAL OF IMMUNOTHERAPY

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Life without Peripheral Serotonin: Insights from Tryptophan Hydroxylase 1 Knockout Mice Reveal the Existence of Paracrine/Autocrine Serotonergic Networks

(2012) Pascal Amireault et al.   ACS Chemical Neuroscience

A Dialogue between the Immune System and Brain, Spoken in the Language of Serotonin

(2012) Nicole L. Baganz et al.   ACS Chemical Neuroscience

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

(2012) D. Duerschmied et al.   BLOOD

Expression of Serotonin Receptors in Human Hepatocellular Cancer

(2012) C. Soll et al.   CLINICAL CANCER RESEARCH

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Measurement of Platelet-Poor Plasma Serotonin:A Systematic Review of Prior Reports and Recommendations for Improved Analysis

(2011) T. Brand et al.   CLINICAL CHEMISTRY

A novel Ly6C/Ly6G-based strategy to analyze the mouse splenic myeloid compartment

(2011) Shawn Rose et al.   CYTOMETRY PART A

Oral administration of fluoxetine alters the proliferation/apoptosis balance of lymphoma cells and up-regulates T cell immunity in tumor-bearing mice

(2011) Luciana Romina Frick et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The platelet contribution to cancer progression

(2010) N. M. BAMBACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Molecular Mechanisms of SERT in Platelets: Regulation of Plasma Serotonin Levels

(2010) C. P. Mercado et al.   MOLECULAR INTERVENTIONS

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Serotonin promotes tumor growth in human hepatocellular cancer

(2009) Christopher Soll et al.   HEPATOLOGY

Peritoneal Colorectal Carcinomatosis Treated With Surgery and Perioperative Intraperitoneal Chemotherapy: Retrospective Analysis of 523 Patients From a Multicentric French Study

(2009) Dominique Elias et al.   JOURNAL OF CLINICAL ONCOLOGY

Antidepressant use and colorectal cancer risk

(2009) Patricia F. Coogan et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

(2009) Nils Paulmann et al.   PLOS BIOLOGY

Inhibitory effect of fluoxetine on lymphoma growth through the modulation of antitumor T-cell response by serotonin-dependent and independent mechanisms

(2008) Luciana Romina Frick et al.   BIOCHEMICAL PHARMACOLOGY

Serotonin Regulates Macrophage-Mediated Angiogenesis in a Mouse Model of Colon Cancer Allografts

(2008) A. Nocito et al.   CANCER RESEARCH

The role of platelet activation in tumor metastasis

(2008) Lubor Borsig   Expert Review of Anticancer Therapy

Discovery and Characterization of Novel Tryptophan Hydroxylase Inhibitors That Selectively Inhibit Serotonin Synthesis in the Gastrointestinal Tract

(2008) Q. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Serotonin: a review

(2008) L. F. MOHAMMAD-ZADEH et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Aggravation of viral hepatitis by platelet-derived serotonin

(2008) Philipp A Lang et al.   NATURE MEDICINE