Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody

CD3 Target Affinity Chromatography Mass Spectrometry as a New Tool for Function–Structure Characterization of T-Cell Engaging Bispecific Antibody Proteoforms and Product-Related Variants

(2023) Steffen Lippold et al.   Analytical Chemistry

Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts

(2022) Yvette M. C. A. Luijkx et al.   MOLECULES

Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry

(2021) Markus Haberger et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Bispecific antibodies poised to deliver wave of cancer therapies

(2021) Cormac Sheridan   NATURE BIOTECHNOLOGY

The state of the art of bispecific antibodies for treating human malignancies

(2021) Shuhang Wang et al.   EMBO Molecular Medicine

Comparative Analysis of Antibodies and Heavily Glycosylated Macromolecular Immune Complexes by Size-Exclusion Chromatography Multi-Angle Light Scattering, Native Charge Detection Mass Spectrometry, and Mass Photometry

(2021) Maurits A. den Boer et al.   ANALYTICAL CHEMISTRY

Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies

(2021) Yuetian Yan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Pushing the limits of native MS: Online SEC-native MS for structural biology applications

(2020) Evolène Deslignière et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

A review of bispecific antibodies and antibody constructs in oncology and clinical challenges

(2019) Frans V. Suurs et al.   PHARMACOLOGY & THERAPEUTICS

Bispecific antibodies: a mechanistic review of the pipeline

(2019) Aran F. Labrijn et al.   NATURE REVIEWS DRUG DISCOVERY

Bioanalytical methods for therapeutic monoclonal antibodies and antibody–drug conjugates: A review of recent advances and future perspectives

(2019) Kenichiro Todoroki et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry

(2019) Christoph Gstöttner et al.   mAbs

Quantitative mass imaging of single biological macromolecules

(2018) Gavin Young et al.   SCIENCE

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

(2018) Aaron O. Bailey et al.   mAbs

Comprehensive characterisation of the heterogeneity of adalimumab via charge variant analysis hyphenated on-line to native high resolution Orbitrap mass spectrometry

(2018) Florian Füssl et al.   mAbs

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Rapid and improved characterization of therapeutic antibodies and antibody related products using IdeS digestion and subunit analysis

(2016) Jonathan Sjögren et al.   ANALYST

Characterization of Chain Pairing Variants of Bispecific IgG Expressed in a Single Host Cell by High-Resolution Native and Denaturing Mass Spectrometry

(2016) Luis Schachner et al.   ANALYTICAL CHEMISTRY

Engineering antibody therapeutics

(2016) Mark L Chiu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs

(2016) Friederike Plath et al.   mAbs

The use of CrossMAb technology for the generation of bi- and multispecific antibodies

(2016) Christian Klein et al.   mAbs

CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors

(2016) Marina Bacac et al.   OncoImmunology

Functional assessment of antibody oxidation by native mass spectrometry

(2015) Markus Haberger et al.   mAbs

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

(2015) Markus Haberger et al.   mAbs

Analysis of Monoclonal Antibody Sequence and Post-translational Modifications by Time-controlled Proteolysis and Tandem Mass Spectrometry

(2015) Lichao Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Detailed mass analysis of structural heterogeneity in monoclonal antibodies using native mass spectrometry

(2014) Sara Rosati et al.   Nature Protocols

Characterization of monoclonal antibody size variants containing extra light chains

(2013) Connie Lu et al.   mAbs

Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry

(2013) Natalie J Thompson et al.   mAbs

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

(2013) Sara Rosati et al.   mAbs

Biosimilar, Biobetter, and Next Generation Antibody Characterization by Mass Spectrometry

(2012) Alain Beck et al.   ANALYTICAL CHEMISTRY

Dual targeting strategies with bispecific antibodies

(2012) Roland Kontermann   mAbs

A sub-two minutes method for monoclonal antibody-aggregate quantification using parallel interlaced size exclusion high performance liquid chromatography

(2011) Patrick Diederich et al.   JOURNAL OF CHROMATOGRAPHY A

Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography

(2010) Başak Kükrer et al.   PHARMACEUTICAL RESEARCH