Post-Column Denaturation-Assisted Native Size-Exclusion Chromatography–Mass Spectrometry for Rapid and In-Depth Characterization of High Molecular Weight Variants in Therapeutic Monoclonal Antibodies

Photoinduced cross-linking of formulation buffer amino acids to monoclonal antibodies

(2021) Thomas Powell et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Analytical characterization of coformulated antibodies as combination therapy

(2020) Jun Kim et al.   mAbs

Versatile, Sensitive, and Robust Native LC–MS Platform for Intact Mass Analysis of Protein Drugs

(2020) Yuetian Yan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related products

(2018) Anthony Ehkirch et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Characterization of product-related low molecular weight impurities in therapeutic monoclonal antibodies using hydrophilic interaction chromatography coupled with mass spectrometry

(2018) Shunhai Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Mapping the Binding Interface in a Noncovalent Size Variant of a Monoclonal Antibody Using Native Mass Spectrometry, Hydrogen–Deuterium Exchange Mass Spectrometry, and Computational Analysis

(2017) Yuetian Yan et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs

(2016) Friederike Plath et al.   mAbs

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

(2015) Markus Haberger et al.   mAbs

New FDA Draft Guidance on Immunogenicity

(2014) Ashwin Parenky et al.   AAPS Journal

Characterization of Small Protein Aggregates and Oligomers Using Size Exclusion Chromatography with Online Detection by Native Electrospray Ionization Mass Spectrometry

(2014) Khaja Muneeruddin et al.   ANALYTICAL CHEMISTRY

Discovery and Characterization of a Photo-Oxidative Histidine-Histidine Cross-Link in IgG1 Antibody Utilizing 18O-Labeling and Mass Spectrometry

(2014) Min Liu et al.   ANALYTICAL CHEMISTRY

Therapeutic protein aggregation: mechanisms, design, and control

(2014) Christopher J. Roberts   TRENDS IN BIOTECHNOLOGY

Intermolecular interactions and conformation of antibody dimers present in IgG1 biopharmaceuticals

(2013) Takafumi Iwura et al.   JOURNAL OF BIOCHEMISTRY

Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements

(2013) Roxana E. Iacob et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of monoclonal antibody size variants containing extra light chains

(2013) Connie Lu et al.   mAbs

Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting

(2013) Galahad Deperalta et al.   mAbs

Structure and Function of Purified Monoclonal Antibody Dimers Induced by Different Stress Conditions

(2012) Rajsekhar Paul et al.   PHARMACEUTICAL RESEARCH

Classification of Protein Aggregates1

(2011) Linda O. Narhi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

(2011) Sarah Zölls et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Fragmentation of monoclonal antibodies

(2011) Josef Vlasak et al.   mAbs

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

(2011) Aming Zhang et al.   PHARMACEUTICAL RESEARCH

Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

(2011) Rebecca J. Rose et al.   STRUCTURE

A Multi-Tiered Analytical Approach For the Analysis and Quantitation of High-Molecular-Weight Aggregates in a Recombinant Therapeutic Glycoprotein

(2009) Heather Hughes et al.   AAPS Journal

Modern analytical ultracentrifugation in protein science: A tutorial review

(2002) Jacob Lebowitz et al.   PROTEIN SCIENCE