Article
Anesthesiology
Dominique Vodovar, Lucie Chevillard, Fabien Caille, Patricia Risede, Geraldine Pottier, Sylvain Auvity, Bruno Megarbane, Nicolas Tournier
Summary: The study examined the respiratory effects of buprenorphine, diazepam, and their combination in rats, finding that the combination induced sedation and respiratory depression. While diazepam did not affect buprenorphine kinetics in the brain or its binding to opioid receptors, the respiratory depression induced by the combination was due to a pharmacodynamic interaction on ventilatory parameters.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Multidisciplinary Sciences
Youyi Zhang, Fei Ye, Tongtong Zhang, Shiyun Lv, Liping Zhou, Daohai Du, He Lin, Fei Guo, Cheng Luo, Shujia Zhu
Summary: Ketamine, as a non-competitive channel blocker of NMDA receptors, can produce rapid and long-lasting antidepressant effects. The S-ketamine enantiomer is found to be the more active antidepressant, with its binding pocket in the NMDA receptor involving key amino acids for interaction.
Article
Environmental Sciences
Diogo Ferreira Bicca, Cristiano Chiapinotto Spiazzi, Juliana Bernera Ramalho, Melina Bucco Soares, Francielli Weber Santos Cibin
Summary: The study revealed that subchronic low dose of GBH could affect behavior and oxidative stress in mouse hippocampus. Quercetin treatment partly or fully improved these effects, but caution is needed regarding the potential independent effects of continuous quercetin supplementation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Abhishek G. Sathe, Ellen Underwood, Lisa D. Coles, Jordan J. Elm, Robert Silbergleit, James M. Chamberlain, Jaideep Kapur, Hannah R. Cock, Nathan B. Fountain, Shlomo Shinnar, Daniel H. Lowenstein, Eric S. Rosenthal, Robin A. Conwit, Thomas P. Bleck, James C. Cloyd
Summary: This study aimed to describe patterns of benzodiazepine use as first-line treatment of status epilepticus (SE) and found that benzodiazepines, particularly midazolam and lorazepam, are frequently underdosed throughout the United States. The study confirmed that underdosing is pervasive and difficult to remediate.
Article
Substance Abuse
T. MacDonald, A. T. Gallo, G. Basso-Hulse, K. S. Bennett, G. K. Hulse
Summary: Low-dose subcutaneous flumazenil may help reduce BZD use and withdrawal symptoms in participants taking daily diazepam equivalent doses greater than or equal to the therapeutic maximum (>30 mg) by reducing the need for diazepam.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Neurosciences
Orsolya Huzian, Judith Baka, Eszter Csakvari, Nikoletta Dobos, Csaba Leranth, Laszlo Siklos, Ronald S. Duman, Tamas Farkas, Tibor Hajszan
Summary: The study found that promoting stress resilience can prevent helpless behavior in rats in the learned helplessness paradigm, while preserving spine synapses in the hippocampus. For the treatment of depression, hippocampal synaptoprotection may be as important as synaptic generation.
Article
Behavioral Sciences
Brenno Bozi, Jeane Rodrigues, Monica Lima-Maximino, Diogenes Henrique de Siqueira-Silva, Marta Candeias Soares, Caio Maximino
Summary: The study of zebrafish revealed that subordinate males and females exhibited higher levels of anxiety-like behavior, indicating a conservation of subordination stress across vertebrates.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Congyue Xu, Qi Xiong, Xiang Tian, Wei Liu, Binlian Sun, Qin Ru, Xiji Shu
Summary: This study found that ferroptosis plays an important role in the mediation of alcohol-induced depressive and anxiety-like behaviors. Alcohol exposure led to neuron damage and reduced levels of synapse-related proteins in mice. It also increased the number of iron-positive staining cells. The ferroptosis inhibitor prevented alcohol-induced neuron damage and enhanced the expression of certain proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Zhi-Heng Zheng, Jiang-Long Tu, Xiao-Han Li, Qing Hua, Wei-Zhu Liu, Yu Liu, Bing-Xing Pan, Ping Hu, Wen -Hua Zhang
Summary: Excessive inflammatory responses are linked to psychiatric diseases, affecting neural plasticity in the amygdala and leading to anxiety and depression symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Review
Neurosciences
Syed Umar Hasan, Alina Pervez, Shaheen Bhatty, Shifa Shamim, Aaima Naeem, Muhammad Wahdan Naseeb
Summary: This network meta-analysis compares different benzodiazepines and their routes of administration on the treatment of seizures. The results show that intramuscular midazolam has the best efficacy in successful seizure cessation, while intranasal midazolam has the best performance in total time for cessation. Intravenous lorazepam is more promising for patients with an established intravenous line, while intranasal midazolam should be the first-line treatment for patients presenting in the emergency room without an intravenous line.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jiahao Zhou, Yao Ma, Jinfeng Chen, Dan Yao, Caixia Feng, Yankai Dong, Yating Ren, Hengyu Ma, Zhifei Wang, Ge Li, Hui Li, Zhongliang Zhu
Summary: This study found that prenatal stress can lead to depression-like behavior in offspring rats, which is associated with elevated expression of RhoA and ROCK1/2 in the hippocampus and prefrontal cortex. Administration of the RhoA inhibitor simvastatin reduces the expression of RhoA and ROCK2, alleviating depression-like behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lihong Ye, Jiayi Wu, Zuyi Liu, Di Deng, Shasha Bai, Lei Yang, Yao Xuan, Zehao Liu, Yafei Shi, Zhongqiu Liu, Rong Zhang, Jinlan Zhao
Summary: This study found that the Si-Ni-San formula (SNS) can alleviate adolescent depression caused by early life stress (ELS), and exert its antidepressant effects by modulating Rac1 activity and spine plasticity in the nucleus accumbens (NAc).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Clinical Neurology
Eric B. Segal, Daniel Tarquinio, Ian Miller, James W. Wheless, Dennis Dlugos, Victor Biton, Gregory D. Cascino, Jay Desai, R. Edward Hogan, Kore Liow, Michael R. Sperling, Blanca Vazquez, David F. Cook, Adrian L. Rabinowicz, Enrique Carrazana
Summary: The study findings show a similar safety profile of diazepam nasal spray in patients with and without concomitant benzodiazepines, consistent with the established profile for diazepam. The results suggest the effectiveness of diazepam nasal spray in patients regardless of concomitant benzodiazepine use, with high study retention rates. These results support the safety and effectiveness of diazepam nasal spray in patients with concomitant benzodiazepine use.
Article
Multidisciplinary Sciences
M. Hibicke, C. D. Nichols
Summary: Psilocybin has demonstrated strong and long-lasting antidepressant effects in human clinical trials and rodent models. This study validates the use of the fly forced swim test (FST) as a cost-effective and high-throughput method for evaluating potential antidepressants. Methamphetamine and DL-alpha-methyltyrosine had no impact on immobility measures in the FST, while chronic citalopram decreased immobility in both male and female flies. High and low doses of psilocybin significantly reduced immobility measures in male flies, with the low dose having a similar effect to chronic citalopram and the high dose having approximately twice the effect size.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Di Deng, Yongfei Cui, Shu Gan, Zedan Xie, Sainan Cui, Kerun Cao, Shanshan Wang, Guoqi Shi, Lei Yang, Shasha Bai, Yafei Shi, Zhongqiu Liu, Jinlan Zhao, Rong Zhang
Summary: This study investigates the mechanism by which Sinisan (SNS) improves depression symptoms. The results show that SNS can alleviate depression-like behaviors by regulating mitochondrial function and synaptic plasticity, reducing the risk of depression induced by early life stress.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)