Article
Biochemistry & Molecular Biology
Ying Zhao, Guibin Mei, Feng Zhou, Bingxuan Kong, Li Chen, Huimin Chen, Lili Wang, Yuhan Tang, Ping Yao
Summary: Vitamin D has been identified as a potential candidate for the intervention of type 2 diabetes. The study reveals that vitamin D may have a protective role in reducing iron deposition in the pancreas of diabetic individuals through the NF-kappa B-DMT1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Joong-Seok Woo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Gi-Hwan Jung, Ji-Youn Jung
Summary: OA treatment leads to induction of apoptosis in melanoma cells through increased apoptotic bodies and decreased expression of antiapoptotic proteins such as Bcl-2.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biotechnology & Applied Microbiology
Farzaneh Hasanian-Langroudi, Asghar Ghasemi, Mehdi Hedayati, Seyed Davar Siadat, Maryam Tohidi
Summary: Type 2 diabetes mellitus is a common disorder worldwide, and the existing treatments have not been satisfactory. Therefore, researchers are seeking treatment options with low toxicity and few adverse effects. The role of gut microbiota in the development of type 2 diabetes mellitus has led to the interest in probiotic supplementation, which is cost-effective, reliable, and safe.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Oncology
Yang Lyu, Bowen Duan, Ziming Liu, Fan Yang, Chen Chen, Xuejiao Jiang, Xiang Liu
Summary: This study found that Sparstolonin B inhibits the growth and induces apoptosis of pancreatic cancer cells through the NFxB signaling pathway, making it a potential novel drug for pancreatic cancer treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Reda F. A. Abdelhameed, Amany K. Ibrahim, Mahmoud A. Elfaky, Eman S. Habib, Mayada Mahamed, Eman T. Mehanna, Khaled M. Darwish, Dina M. Khodeer, Safwat A. Ahmed, Sameh S. Elhady
Summary: Cynanchum acutum L. is a climbing vine in the Apocynaceae family, and seven compounds were isolated from its methanolic extract, including six flavonoids with anti-inflammatory and antioxidant properties. Among them, quercetin-3-O-galactoside and quercetin demonstrated superior anti-inflammatory activity compared to other bioactive metabolites.
Article
Medicine, Research & Experimental
Mohamed Sadek Abdel-Bakky, Abdulmajeed Alqasoumi, Waleed Mohammad Altowayan, Elham Amin, Mostafa Assem Darwish
Summary: The study investigated the roles of ADAM10 and ADAM17 in T1DM, and the protective effects of SIM in STZ-induced T1DM. The results showed that SIM could reduce pancreatic inflammation and cell apoptosis, and decrease the expression of key proteins, alleviating the pathological damage of T1DM.
Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yang Lu, Ping Li, Yuandong Zhou, Jian Zhang
Summary: This study found that PKMYT1 is highly expressed in osteosarcoma and is associated with poor prognosis. It promotes the malignant progression of MG63 cells through negatively regulating the NF-κB pathway, suggesting that PKMYT1 may be a potential molecular therapeutic target for the treatment of osteosarcoma.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying-Ya Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-Na Wu, Li-Li Wu, Kai Song, Wei-Hua Lu, Jian-Bo Yu
Summary: This study reveals the protective role of PLK1 in maintaining intestinal barrier integrity during sepsis. The PLK1/TANK/NF-kappa B axis plays a crucial role in sepsis-induced intestinal barrier dysfunction by regulating mitochondrial dynamics and apoptosis in the intestinal epithelium, and may serve as a potential therapeutic target.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Maha H. Sharawy, Dalia H. El-Kashef, Ahmed A. Shaaban, Dina S. El-Agamy
Summary: This study demonstrated the hepatoprotective activity of sitagliptin against Con A-induced hepatic fibrosis, potentially through enhancement of the Nrf2 signaling pathway and inhibition of NF-Kappa B. Sitagliptin may be a new candidate for suppressing hepatitis-associated fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Neurosciences
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a traumatic central nervous system injury that can lead to severe nerve damage. Inflammatory response plays a crucial role in secondary injury. Prolonged inflammation can worsen the injured site's microenvironment, resulting in neural function deterioration. Understanding the NF-kappa B pathway and its regulation of inflammation after SCI is crucial for developing new therapies. Inhibiting the NF-kappa B pathway improves the inflammatory microenvironment and enhances neural function recovery, making it a potential therapeutic target for SCI.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Fouad M. F. Elshaghabee, Namita Rokana
Summary: Multi-drug resistant microbes pose a serious threat to health security and the economy. This review focuses on the use of probiotics, prebiotics, and synbiotics as alternative drugs to improve immunity and reduce infections and antimicrobial resistance. These approaches rely on different mechanisms, including colonization interference, antimicrobial activity, restoration of mucosal barrier function, immunomodulation, and maintaining intestinal homeostasis.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Review
Biotechnology & Applied Microbiology
Vishu Chaudhary, Priya Katyal, Anuj Kumar Poonia, Jaspreet Kaur, Anil Kumar Puniya, Harsh Panwar
Summary: The advantages of natural colorant over synthetic one are highlighted in this review, with a focus on the fermentation parameters that can improve the productivity of Monascus pigment. Natural colors have become a preference in the food industry due to their aesthetic value and non-toxicity, while synthetic colors have been banned due to their toxicity and carcinogenicity. Microbial pigments, such as those from Monascus, are considered a viable option due to scalability, easier production, cheaper raw materials, and easier extraction.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Review
Food Science & Technology
Brij Pal Singh, Sneh Punia Bangar, Munira Alblooshi, Feyisola Fisayo Ajayi, Priti Mudgil, Sajid Maqsood
Summary: The development of plant proteins as sustainable alternatives to traditional animal proteins is a major challenge in the agri-food industry. Plant proteins not only serve as a sustainable source of protein, but also have functional and health-promoting properties due to active peptides. This review comprehensively discusses the importance of plant-based proteins, their production and characterization, and the bioactivities and bioavailability of plant protein-derived bioactive peptides.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Vishu Chaudhary, Priya Katyal, Harsh Panwar, Jaspreet Kaur, Rotimi E. Aluko, Anil Kumar Puniya, Anuj Kumar Poonia
Summary: This study evaluated the therapeutic potential of a red biopigment extracted from Monascus purpureus using solid-state fermentation on human prostate LNCaP cells. The biopigment demonstrated strong antioxidant and anti-inflammatory effects, as well as cytotoxicity against cancer cells, making it a promising supplement for the treatment of inflammatory-related diseases.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Microbiology
Kirankumar Nalla, Naresh Kumar Manda, Harmeet Singh Dhillon, Santosh R. Kanade, Namita Rokana, Matthias Hess, Anil Kumar Puniya
Summary: Studies have shown that probiotics can modulate the microbial community composition in the gastrointestinal tract and improve the productivity of dairy animals. However, detailed changes on the molecular and metabolic level prompted by probiotic feed additives are still not understood.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Food Science & Technology
Priti Mudgil, Munira Alblooshi, Brij Pal Singh, Aarthi Rekha Devarajan, Sajid Maqsood
Summary: This study found that pearl millet protein hydrolysates have multiple bioactive properties and potential anti-diabetic, anti-lipidemic, and anti-oxidant activities.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Munira Alblooshi, Aarthi Rekha Devarajan, Brij Pal Singh, Preethi Ramakrishnan, Hussein Mostafa, Hina Kamal, Priti Mudgil, Sajid Maqsood
Summary: Colocynth, a traditional Chinese herbal medicine, has potential applications as a nutraceutical and functional food ingredient. Enzymatic hydrolysis of colocynth seed protein using proteolytic enzymes (alcalase, bromelain, and chymotrypsin) resulted in the highest degree of hydrolysis (87.82%) after 9 hours of chymotrypsin treatment. The hydrolysates showed superior antioxidant activity and inhibition of enzymes related to diabetes and hyperlipidemia.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Anamika Singh, Rachael Terumbur Duche, Arundhati Ganesh Wandhare, Jaspreet Kaur Sian, Brij Pal Singh, Manvesh Kumar Sihag, Kumar Siddharth Singh, Vikas Sangwan, Shreya Talan, Harsh Panwar
Summary: The growing consumer awareness towards healthy and safe food has led to a reform in food processing strategies. Milk, with its rich source of functional peptides, is being explored as a natural and safe substitute to enhance the shelf life of food products.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Infectious Diseases
Brij Pal Singh, K. M. Manju, Rohit Sharma, Bharat Bhushan, Sougata Ghosh, Gunjan Goel
Summary: In recent years, the expansion of the food industry and processed food products has led to increased attention towards microbial food safety and the development of novel preservation methods. Food-derived antimicrobial peptides (F-AMPs) are emerging as a pragmatic alternative for extending the shelf-life of food products, with their wide spectrum antimicrobial efficacy and low propensity for antibiotic resistance. However, their direct application in food is limited and the development of nanocarriers for their conjugation and distribution could greatly enhance their bioactivity.
Article
Food Science & Technology
Vishu Chaudhary, Priya Katyal, Anil Kumar Puniya, Harsh Panwar, Maninder Arora, Jaspreet Kaur, Namita Rokana, Nitin Wakchaure, Antonio Raposo, Dele Raheem, Anuj Kumar Poonia
Summary: This study successfully produced natural red bio-pigment at a pilot-scale by optimizing fermenter type and bio-pigment extraction parameters. The tray-type fermenter outperformed other types for bio-pigment production. The high yield of bio-pigment was extracted with 60% ethanol at 60°C for 80 min. The study also found three color forms of bio-pigment in the extract, namely red, orange, and yellow. The extracted red bio-pigment exhibited sensitivity to UV, sunlight, and pH > 10, but could withstand high temperature and low concentrations of food preservatives.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Review
Cell Biology
Naresh Kumar Manda, Upendarrao Golla, Kishore Sesham, Parth Desai, Shrushti Joshi, Satyam Patel, Sharada Nalla, Susmitha Kondam, Lakhwinder Singh, Deepak Dewansh, Hemalatha Manda, Namita Rokana
Summary: The organization of eukaryotic genome in the nucleus is complex and dynamic, and its morphology and size have significant impact on nuclear mechanics, chromatin organization, gene expression, cell functionality, and disease development. Abnormal nuclear envelope morphologies are implicated in human disorders. However, our knowledge about the molecular mechanisms regulating nuclear morphology and cell functionality during health and illness is limited. This review discusses the essential components governing nuclear organization and the functional consequences associated with nuclear morphometric aberrations, as well as recent developments with diagnostic and therapeutic implications for nuclear morphology.
Article
Food Science & Technology
Rusli Fidriyanto, Brij Pal Singh, K. M. Manju, Yantyati Widyastuti, Gunjan Goel
Summary: In recent years, there has been an increasing interest in diets rich in fibers for their documented health benefits, leading to the exploration of novel dietary fibers from different sources. This study focused on extracting insoluble dietary fibers from apple pomace, an industrial waste rich in fibers, and evaluating the effect of different extraction methods on their physico-chemical, structural, functional, and prebiotic properties. The results showed that hot water extraction resulted in the highest yield of dietary fibers and the acid-extracted fraction exhibited the highest water and oil holding capacity. The hot water-extracted fibers also showed the maximum increase in viable cell count of probiotic strains, indicating their potential as prebiotic substrates. These findings suggest that hot water-extracted dietary fibers can be used to improve the textural, functional, and bioactive properties of foods.
FOOD PRODUCTION PROCESSING AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Keval Chopada, Bethsheba Basaiawmoit, Amar A. Sakure, Ruchika Maurya, Mahendra Bishnoi, Kanthi Kiran Kondepudi, Divyang Solanki, B. P. Singh, Srichandan Padhi, Amit Kumar Rai, Zhenbin Liu, B. K. Mishra, Subrota Hati
Summary: The objective of this research was to purify and characterize novel ACE-inhibitory and antioxidant peptides from fermented whey protein concentrate produced by Lactobacillus paracasei and Saccharomyces cerevisiae. Through various experiments and analyses, bioactive peptides were discovered and their anti-inflammatory activities were investigated. These findings may contribute to the design of pharmacologically active ingredients for health applications in the future.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2023)
Review
Biotechnology & Applied Microbiology
Vishu Chaudhary, Priya Katyal, Anuj Kumar Poonia, Jaspreet Kaur, Anil Kumar Puniya, Harsh Panwar
Summary: This review highlights the advantages of using natural colorants in the food industry over synthetic ones. Natural colorants not only enhance the aesthetic value and attractiveness of food, but also have nutritional and therapeutic significance. Microbial pigments, such as those produced by Monascus, are considered a viable option due to scalability, easier production, cheaper raw materials, and easier extraction. However, there are challenges in pilot-scale production and stabilization of the pigments, which are being addressed through various methods.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
