Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1

(2016) Michel Brahic et al.   ACTA NEUROPATHOLOGICA

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients

(2016) Morten Gersel Stokholm et al.   ANNALS OF NEUROLOGY

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation

(2016) Sara Breid et al.   JOURNAL OF VIROLOGY

Assessment of α-synuclein in submandibular glands of patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study

(2016) Dolores Vilas et al.   LANCET NEUROLOGY

Pathology: The prion principle

(2016) Simon Makin   NATURE

Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum

(2016) D. F. Sharrad et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cell Biology of Prions and Prionoids: A Status Report

(2016) Adriano Aguzzi et al.   TRENDS IN CELL BIOLOGY

Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases

(2016) Heiko Braak et al.   Cold Spring Harbor Perspectives in Biology

Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson’s Disease

(2016) Giorgio Vivacqua et al.   PLoS One

A new dopaminergic nigro-olfactory projection

(2015) Günter U. Höglinger et al.   ACTA NEUROPATHOLOGICA

Vagotomy and subsequent risk of Parkinson's disease

(2015) Elisabeth Svensson et al.   ANNALS OF NEUROLOGY

Alteration of Upstream Autophagy-Related Proteins (ULK1, ULK2, Beclin1, VPS34 and AMBRA1) in Lewy Body Disease

(2015) Yasuo Miki et al.   BRAIN PATHOLOGY

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Neuropathology of α-synuclein propagation and braak hypothesis

(2015) Heather McCann et al.   MOVEMENT DISORDERS

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis

(2015) Jennifer T. Lamberts et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

(2015) Iban Aldecoa et al.   NEUROSCIENCE LETTERS

Propagation of prions causing synucleinopathies in cultured cells

(2015) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets

(2015) Rita Marreiros et al.   VIRUS RESEARCH

Editorial: Parkinson's disease: cell vulnerability and disease progression

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

(2015) Hiroyuki Sumikura et al.   Acta Neuropathologica Communications

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Formaldehyde-fixed brain tissue from spontaneously ill α-synuclein transgenic mice induces fatal α-synucleinopathy in transgenic hosts

(2014) Manuel Schweighauser et al.   ACTA NEUROPATHOLOGICA

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Under-reporting of Parkinson's disease on death certificates: A population-based study (NEDICES)

(2014) Julián Benito-León et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes

(2014) Laura A. Volpicelli-Daley et al.   MOLECULAR BIOLOGY OF THE CELL

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

(2014) Anke A. Dijkstra et al.   MOVEMENT DISORDERS

Neuropathology of prodromal Lewy body disease

(2014) Alex Iranzo et al.   MOVEMENT DISORDERS

In vivo gastric detection of α-synuclein inclusions in Parkinson's disease

(2014) Álvaro Sánchez-Ferro et al.   MOVEMENT DISORDERS

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Imaging prodromal Parkinson disease: The Parkinson Associated Risk Syndrome Study

(2014) D. Jennings et al.   NEUROLOGY

Olfactory dysfunction in incidental Lewy body disease and Parkinson's disease

(2014) Erika Driver-Dunckley et al.   PARKINSONISM & RELATED DISORDERS

Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients

(2014) Alex Iranzo et al.   PLoS One

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys

(2013) Ariadna Recasens et al.   ANNALS OF NEUROLOGY

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

Caudo-rostral brain spreading of α-synuclein through vagal connections

(2013) Ayse Ulusoy et al.   EMBO Molecular Medicine

Risk factors and prodromal markers and the development of Parkinson’s disease

(2013) Stefanie Lerche et al.   JOURNAL OF NEUROLOGY

Idiopathic REM sleep behaviour disorder in the development of Parkinson's disease

(2013) Bradley F Boeve   LANCET NEUROLOGY

Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study

(2013) Alex Iranzo et al.   LANCET NEUROLOGY

Parkinson's Disease: “Braak” to the future

(2013) Javier Blesa   MOVEMENT DISORDERS

Lysosomal impairment in Parkinson's disease

(2013) Benjamin Dehay et al.   MOVEMENT DISORDERS

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Adenosine-Mediated Enteric Neuromuscular Function Is Affected during Herpes Simplex Virus Type 1 Infection of Rat Enteric Nervous System

(2013) Chiara Zoppellaro et al.   PLoS One

Viruses and neurodegeneration

(2013) Li Zhou et al.   Virology Journal

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

(2013) Amanda N Sacino et al.   Acta Neuropathologica Communications

Spinal cord lesions in sporadic Parkinson’s disease

(2012) Kelly Del Tredici et al.   ACTA NEUROPATHOLOGICA

Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease?

(2012) Glenda Halliday et al.   Expert Review of Neurotherapeutics

Activity-dependent secretion of alpha-synuclein by enteric neurons

(2012) Sébastien Paillusson et al.   JOURNAL OF NEUROCHEMISTRY

Thalamic noradrenaline in Parkinson's disease: Deficits suggest role in motor and non-motor symptoms

(2012) Christian Pifl et al.   MOVEMENT DISORDERS

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome study

(2012) Andrew Siderowf et al.   MOVEMENT DISORDERS

Lewy pathology and neurodegeneration in premotor Parkinson's disease

(2012) Kelly Del Tredici et al.   MOVEMENT DISORDERS

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

The significance of defining preclinical or prodromal Parkinson's disease

(2012) C. Warren Olanow et al.   MOVEMENT DISORDERS

Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines

(2012) Irene Litvan et al.   MOVEMENT DISORDERS

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system

(2012) Ali Reza Noorian et al.   NEUROBIOLOGY OF DISEASE

Neuropathologic analysis of Lewy-related α-synucleinopathy in olfactory mucosa

(2012) Sayaka Funabe et al.   NEUROPATHOLOGY

Alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism

(2012) Judith Navarro-Otano et al.   PARKINSONISM & RELATED DISORDERS

Alpha-Synuclein Cell-to-Cell Transfer and Seeding in Grafted Dopaminergic Neurons In Vivo

(2012) Elodie Angot et al.   PLoS One

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Beyond α-synuclein transfer: pathology propagation in Parkinson's disease

(2012) Christian Hansen et al.   TRENDS IN MOLECULAR MEDICINE

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice

(2012) Francisco Pan-Montojo et al.   Scientific Reports

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

A critical appraisal of the premotor symptoms of Parkinson's disease: Potential usefulness in early diagnosis and design of neuroprotective trials

(2011) Anthony E. Lang   MOVEMENT DISORDERS

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

(2011) Anne-Laure Mougenot et al.   NEUROBIOLOGY OF AGING

Progression of monoaminergic dysfunction in Parkinson's disease: A longitudinal 18F-dopa PET study

(2011) Nicola Pavese et al.   NEUROIMAGE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder

(2011) B. N. Dugger et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Patterns of alpha-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

(2011) Wilma D.J. van de Berg et al.   PARKINSONISM & RELATED DISORDERS

Can Parkinson's disease pathology be propagated from one neuron to another?

(2011) Christopher J.R. Dunning et al.   PROGRESS IN NEUROBIOLOGY

Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

(2010) Brittany N. Dugger et al.   ACTA NEUROPATHOLOGICA

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

(2010) Kunikazu Tanji et al.   ACTA NEUROPATHOLOGICA

When Does Parkinson Disease Start?

(2010) Rodolfo Savica et al.   ARCHIVES OF NEUROLOGY

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

(2010) Karin M. Danzer et al.   FASEB JOURNAL

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

(2010) Carine Karachi et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence in favor of Braak staging of Parkinson's disease

(2010) Dennis W. Dickson et al.   MOVEMENT DISORDERS

Missing pieces in the Parkinson's disease puzzle

(2010) Jose A Obeso et al.   NATURE MEDICINE

Cell-to-cell transmission of non-prion protein aggregates

(2010) Seung-Jae Lee et al.   Nature Reviews Neurology

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

The propagation of prion-like protein inclusions in neurodegenerative diseases

(2010) Michel Goedert et al.   TRENDS IN NEUROSCIENCES

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

(2009) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

Staging/typing of Lewy body related α-synuclein pathology: a study of the BrainNet Europe Consortium

(2009) Irina Alafuzoff et al.   ACTA NEUROPATHOLOGICA

Parkinson's Disease

(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Mild cognitive impairment associated with limbic and neocortical lewy body disease: a clinicopathological study

(2009) Jennifer Molano et al.   BRAIN

Lewy Body Pathology in Normal Elderly Subjects

(2009) William R. Markesbery et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

(2009) Philipp A Jaeger et al.   Molecular Neurodegeneration

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Incidental Lewy body disease: Do some cases represent a preclinical stage of dementia with Lewy bodies?

(2009) Roberta Frigerio et al.   NEUROBIOLOGY OF AGING

Neuropathology of non-motor features of Parkinson disease

(2009) Dennis W. Dickson et al.   PARKINSONISM & RELATED DISORDERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-localization of tau and α-synuclein in the olfactory bulb in Alzheimer’s disease with amygdala Lewy bodies

(2008) Hiroshige Fujishiro et al.   ACTA NEUROPATHOLOGICA

Cardiac sympathetic denervation in Parkinson’s disease linked to SNCA duplication

(2008) Satoshi Orimo et al.   ACTA NEUROPATHOLOGICA

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease

(2008) Dennis W. Dickson et al.   ACTA NEUROPATHOLOGICA

The progression of pathology in longitudinally followed patients with Parkinson’s disease

(2008) Glenda Halliday et al.   ACTA NEUROPATHOLOGICA

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

(2008) Richard L. Doty   ANNALS OF NEUROLOGY

Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb

(2008) Renpei Sengoku et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

(2008) Hiroshige Fujishiro et al.   MOVEMENT DISORDERS

Olfactory pathogenesis of idiopathic Parkinson disease revisited

(2008) Alicja Lerner et al.   MOVEMENT DISORDERS

Neural control of the gastrointestinal tract: Implications for Parkinson disease

(2008) Maria G. Cersosimo et al.   MOVEMENT DISORDERS

Transplanted dopaminergic neurons develop PD pathologic changes: A second case report

(2008) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Bowel movement frequency in late-life and substantia nigra neuron density at death

(2008) Helen Petrovitch et al.   MOVEMENT DISORDERS

Assessing fetal nerve cell grafts in Parkinson's disease

(2008) Heiko Braak et al.   NATURE MEDICINE

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Patterns and stages of  -synucleinopathy: Relevance in a population-based cohort

(2008) J. Zaccai et al.   NEUROLOGY

Invited Article: Nervous system pathology in sporadic Parkinson disease

(2008) H. Braak et al.   NEUROLOGY

Alpha-synuclein-immunopositive myenteric neurons and vagal preganglionic terminals: Autonomic pathway implicated in Parkinson's disease?

(2008) R.J. Phillips et al.   NEUROSCIENCE

Axonal  -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

(2007) S. Orimo et al.   BRAIN