Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases

Erectile Dysfunction Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study in Olmsted County

(2019) Shemonti Hasan et al.   Parkinsons Disease

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease

(2019) Sangjune Kim et al.   NEURON

Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies

(2018) Ivan Martinez-Valbuena et al.   ACTA NEUROPATHOLOGICA

RAGE binds preamyloid IAPP intermediates and mediates pancreatic β cell proteotoxicity

(2018) Andisheh Abedini et al.   JOURNAL OF CLINICAL INVESTIGATION

Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease

(2018) Annekatrin König et al.   Journal of Parkinsons Disease

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

(2018) Jessika C. Bridi et al.   Frontiers in Neuroscience

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease

(2018) Qian-Qian Chen et al.   Translational Neurodegeneration

Is constipation in Parkinson's disease caused by gut or brain pathology?

(2018) Per Borghammer   PARKINSONISM & RELATED DISORDERS

Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study

(2018) Ga Eun Nam et al.   PLOS MEDICINE

Introduction: Standards of Medical Care in Diabetes—2019

(2018)   DIABETES CARE

Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys

(2017) Feng Yue et al.   EXPERIMENTAL GERONTOLOGY

Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism

(2017) Abhisek Mukherjee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

(2017) Dilan Athauda et al.   LANCET

Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease

(2017) Chong-Bin Zhong et al.   Neuroscience Bulletin

The Synucleinopathies: Twenty Years On

(2017) Michel Goedert et al.   Journal of Parkinsons Disease

Diabetic Neuropathy and Gait: A Review

(2017) Uazman Alam et al.   Diabetes Therapy

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Diabetic Neuropathy and Gait: A Review

(2017) Uazman Alam et al.   Diabetes Therapy

Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections

(2016) Ayse Ulusoy et al.   ACTA NEUROPATHOLOGICA

Imaging Systemic Dysfunction in Parkinson’s Disease

(2016) Per Borghammer et al.   Current Neurology and Neuroscience Reports

Alpha-synuclein structure, functions, and interactions

(2016) FatemehNouri Emamzadeh   Journal of Research in Medical Sciences

Age- and sex-related changes in fasting plasma glucose and lipoprotein in cynomolgus monkeys

(2016) Feng Yue et al.   Lipids in Health and Disease

Risk of Parkinson Disease in Diabetes Mellitus

(2016) Xuejing Yue et al.   MEDICINE

Cross-talk between amyloidogenic proteins in type-2 diabetes and Parkinson’s disease

(2016) Istvan Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin-degrading enzyme is activated by the C-terminus of α-synuclein

(2015) Sandeep K. Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Insulin Resistance andAPOEε4

(2015) Auriel A. Willette et al.   JAMA Neurology

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Risk Factors Contributing to Type 2 Diabetes and Recent Advances in the Treatment and Prevention

(2014) Yanling Wu et al.   International Journal of Medical Sciences

System-based approaches to decode the molecular links in Parkinson's disease and diabetes

(2014) Jose A. Santiago et al.   NEUROBIOLOGY OF DISEASE

Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons

(2014) Domingo Afonso-Oramas et al.   Frontiers in Neuroanatomy

Alpha-synuclein biology in Lewy body diseases

(2014) Woojin Scott Kim et al.   Alzheimers Research & Therapy

One year of sitagliptin treatment protects against islet amyloid-associated β-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice

(2013) Kathryn Aston-Mourney et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lessons from two prevalent amyloidoses—what amylin and Aβ have in common

(2013) Jürgen Götz et al.   Frontiers in Aging Neuroscience

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes

(2013) Karen Pillay et al.   Biomed Research International

Beta Cell Dysfunction and Insulin Resistance

(2013) Marlon E. Cerf   Frontiers in Endocrinology

The prion hypothesis in Parkinson's disease: Braak to the future

(2013) Naomi P Visanji et al.   Acta Neuropathologica Communications

Parkinson's disease, insulin resistance and novel agents of neuroprotection

(2012) Iciar Aviles-Olmos et al.   BRAIN

Diabetes and Hypertension: Is There a Common Metabolic Pathway?

(2012) Bernard M. Y. Cheung et al.   Current Atherosclerosis Reports

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort

(2012) Mark L. Wahlqvist et al.   PARKINSONISM & RELATED DISORDERS

Short-Term Intensive Therapy in Newly Diagnosed Type 2 Diabetes Partially Restores Both Insulin Sensitivity and β-Cell Function in Subjects With Long-Term Remission

(2011) Yun Hu et al.   DIABETES CARE

Obesity, diabetes, and risk of Parkinson's disease

(2011) Natalia Palacios et al.   MOVEMENT DISORDERS

α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion

(2010) Xuehui Geng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lysophosphatidic Acid Inhibits CC Chemokine Ligand 5/RANTES Production by Blocking IRF-1-Mediated Gene Transcription in Human Bronchial Epithelial Cells

(2010) S. Matsuzaki et al.   JOURNAL OF IMMUNOLOGY

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Diagnosis and Classification of Diabetes Mellitus

(2009)   DIABETES CARE

Diabetes preceding Parkinson's disease onset. A case–control study

(2009) Marco D'Amelio et al.   PARKINSONISM & RELATED DISORDERS

Neuropathology of non-motor features of Parkinson disease

(2009) Dennis W. Dickson et al.   PARKINSONISM & RELATED DISORDERS

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

(2008) Jia-Yi Li et al.   NATURE MEDICINE