The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

(2022) Ting Zhang et al.   NATURE

Landscape of adenosine-to-inosine RNA recoding across human tissues

(2022) Orshay Gabay et al.   Nature Communications

ADAR1 mutation causes ZBP1-dependent immunopathology

(2022) Nicholas W. Hubbard et al.   NATURE

ADAR1 averts fatal type I interferon induction by ZBP1

(2022) Huipeng Jiao et al.   NATURE

To “Z” or not to “Z”: Z-RNA, self-recognition, and the MDA5 helicase

(2021) Alan Herbert   PLoS Genetics

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain

(2021) Jung In Kim et al.   PLoS Genetics

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

(2021) Megan Maurano et al.   IMMUNITY

Mutations in the adenosine deaminase ADAR1 that prevent endogenous Z-RNA binding induce Aicardi-Goutières-syndrome-like encephalopathy

(2021) Taisuke Nakahama et al.   IMMUNITY

Adenosine-to-inosine editing of endogenous Z-form RNA by the deaminase ADAR1 prevents spontaneous MAVS-dependent type I interferon responses

(2021) Qiannan Tang et al.   IMMUNITY

Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain

(2021) Xinfeng Guo et al.   Journal of Neuroinflammation

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation

(2021) Richard de Reuver et al.   Cell Reports

Deciphering the Biological Significance of ADAR1–Z-RNA Interactions

(2021) Taisuke Nakahama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Aicardi-Goutières Syndrome–Causative Point Mutation in Adar1 Gene Invokes Multiorgan Inflammation and Late-Onset Encephalopathy in Mice

(2021) Maal Inoue et al.   JOURNAL OF IMMUNOLOGY

Recognizing limits of Z‐nucleic acid binding protein (ZBP1/DAI/DLM1) function

(2020) Heather S. Koehler et al.   FEBS Journal

An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype

(2020) Prajakta Bajad et al.   NUCLEIC ACIDS RESEARCH

A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

(2020) Pedro Henrique Costa Cruz et al.   RNA

Tximeta: Reference sequence checksums for provenance identification in RNA-seq

(2020) Michael I. Love et al.   PLoS Computational Biology

Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

(2020) Ting Zhang et al.   CELL

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

ADAR-deficiency perturbs the global splicing landscape in mouse tissues

(2020) Utkarsh Kapoor et al.   GENOME RESEARCH

eIF2B activator prevents neurological defects caused by a chronic integrated stress response

(2019) Yao Liang Wong et al.   eLife

Mendelian disease caused by variants affecting recognition of Z-DNA and Z-RNA by the Zα domain of the double-stranded RNA editing enzyme ADAR

(2019) Alan Herbert   EUROPEAN JOURNAL OF HUMAN GENETICS

A high resolution A-to-I editing map in the mouse identifies editing events controlled by pre-mRNA splicing

(2019) Konstantin Licht et al.   GENOME RESEARCH

Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity

(2019) Shalom Hillel Roth et al.   NATURE METHODS

OUP accepted manuscript

(2018)   BIOINFORMATICS

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

(2018) Hachung Chung et al.   CELL

A-to-I RNA editing — immune protector and transcriptome diversifier

(2018) Eli Eisenberg et al.   NATURE REVIEWS GENETICS

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss

(2018) Huayang Liu et al.   NATURE MEDICINE

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150

(2018) Christian K. Pfaller et al.   PLOS BIOLOGY

Dynamic landscape and regulation of RNA editing in mammals

(2017) Meng How Tan et al.   NATURE

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Genetic, Phenotypic, and Interferon Biomarker Status in ADAR1-Related Neurological Disease

(2017) Gillian Rice et al.   NEUROPEDIATRICS

RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure

(2017) Oz Solomon et al.   Nature Communications

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis

(2016) Brian J. Liddicoat et al.   EXPERIMENTAL HEMATOLOGY

Structural and functional studies of a large winged Z-DNA-binding domain ofDanio rerioprotein kinase PKZ

(2016) Vinod Kumar Subramani et al.   FEBS LETTERS

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

RIPK1 inhibits ZBP1-driven necroptosis during development

(2016) Kim Newton et al.   NATURE

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

Goldmine integrates information placing genomic ranges into meaningful biological contexts

(2016) Jeffrey M. Bhasin et al.   NUCLEIC ACIDS RESEARCH

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Profiling RNA editing in human tissues: towards the inosinome Atlas

(2015) Ernesto Picardi et al.   Scientific Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

(2015) Brian J. Liddicoat et al.   Wiley Interdisciplinary Reviews-RNA

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis

(2014) Monique F. Smeets et al.   JOURNAL OF CLINICAL INVESTIGATION

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome

(2014) Yishay Pinto et al.   GENOME BIOLOGY

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

A type I interferon signature identifies bilateral striatal necrosis due to mutations inADAR1

(2013) John H Livingston et al.   JOURNAL OF MEDICAL GENETICS

Quantifying RNA allelic ratios by microfluidic multiplex PCR and sequencing

(2013) Rui Zhang et al.   NATURE METHODS

Identifying RNA editing sites using RNA sequencing data alone

(2013) Gokul Ramaswami et al.   NATURE METHODS

Quantitative set analysis for gene expression: a method to quantify gene set differential expression including gene-gene correlations

(2013) Gur Yaari et al.   NUCLEIC ACIDS RESEARCH

RADAR: a rigorously annotated database of A-to-I RNA editing

(2013) Gokul Ramaswami et al.   NUCLEIC ACIDS RESEARCH

Global regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR)

(2013) O. Solomon et al.   RNA

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

The UCSC Genome Browser database: extensions and updates 2013

(2012) Laurence R. Meyer et al.   NUCLEIC ACIDS RESEARCH

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

(2011) S. Singbrant et al.   BLOOD

ADAR1 isoform involvement in embryonic lethality

(2011) R. A. Steinman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY