Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

Deep learning predicts chromosomal instability from histopathology images

(2021) Zhuoran Xu et al.   iScience

Chromosomal copy number heterogeneity predicts survival rates across cancers

(2021) Erik van Dijk et al.   Nature Communications

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

(2020) Anand Vasudevan et al.   DEVELOPMENTAL CELL

Acquisition of chromosome instability is a mechanism to evade oncogene addiction

(2020) Lorena Salgueiro et al.   EMBO Molecular Medicine

Chromosome arm aneuploidies shape tumour evolution and drug response

(2020) Ankit Shukla et al.   Nature Communications

Morphology-predicted large scale transition number in circulating tumor cells identifies a chromosomal instability biomarker associated with poor outcome in castration-resistant prostate cancer

(2020) Joseph D. Schonhoft et al.   CANCER RESEARCH

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

(2020) John Michael Replogle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Enables Cross-Adaptation to Unrelated Drugs

(2019) Feng Yang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Molecular design and anticancer activities of small-molecule monopolar spindle 1 inhibitors: A Medicinal chemistry perspective

(2019) Shutao Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

(2018) Jianfang Liu et al.   CELL

Quantitative proteomic and phosphoproteomic comparison of human colon cancer DLD-1 cells differing in ploidy and chromosome stability

(2018) Cristina Viganó et al.   MOLECULAR BIOLOGY OF THE CELL

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis

(2018) Joan C Smith et al.   eLife

Patient-derived xenografts undergo mouse-specific tumor evolution

(2017) Uri Ben-David et al.   NATURE GENETICS

Modeling Genomic Instability and Selection Pressure in a Mouse Model of Melanoma

(2017) Lawrence N. Kwong et al.   Cell Reports

Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

(2016) Laura C. Funk et al.   DEVELOPMENTAL CELL

SMASH, a fragmentation and sequencing method for genomic copy number analysis

(2016) Zihua Wang et al.   GENOME RESEARCH

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Targeting the Adaptability of Heterogeneous Aneuploids

(2015) Guangbo Chen et al.   CELL

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

(2015) Anastasia Y Kuznetsova et al.   CELL CYCLE

Aneuploidy-induced cellular stresses limit autophagic degradation

(2015) Stefano Santaguida et al.   GENES & DEVELOPMENT

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

(2015) Hui Gao et al.   NATURE MEDICINE

Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells

(2015) Akihiro Ohashi et al.   Nature Communications

Unique features of the transcriptional response to model aneuploidy in human cells

(2014) Milena Dürrbaum et al.   BMC GENOMICS

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

(2014) H. Rizos et al.   CLINICAL CANCER RESEARCH

HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells

(2014) N. Donnelly et al.   EMBO JOURNAL

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

A Transcriptional and Metabolic Signature of Primary Aneuploidy Is Present in Chromosomally Unstable Cancer Cells and Informs Clinical Prognosis

(2013) J. M. Sheltzer   CANCER RESEARCH

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

Resistance to BRAF-targeted therapy in melanoma

(2013) Ryan J. Sullivan et al.   EUROPEAN JOURNAL OF CANCER

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy

(2012) A. Kathleen McClendon et al.   CELL CYCLE

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

Cancer chromosomal instability: therapeutic and diagnostic challenges

(2012) Nicholas McGranahan et al.   EMBO REPORTS

Aneuploidy causes proteotoxic stress in yeast

(2012) A. B. Oromendia et al.   GENES & DEVELOPMENT

Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells

(2012) Silvia Stingele et al.   Molecular Systems Biology

Hsp90 stress potentiates rapid cellular adaptation through induction of aneuploidy

(2012) Guangbo Chen et al.   NATURE

Genome-wide copy number analysis of single cells

(2012) Timour Baslan et al.   Nature Protocols

Causes and consequences of aneuploidy in cancer

(2012) David J. Gordon et al.   NATURE REVIEWS GENETICS

Transcriptional consequences of aneuploidy

(2012) J. M. Sheltzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

The aneuploidy paradox: costs and benefits of an incorrect karyotype

(2011) Jason M. Sheltzer et al.   TRENDS IN GENETICS

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acquisition of Aneuploidy Provides Increased Fitness during the Evolution of Antifungal Drug Resistance

(2009) Anna M. Selmecki et al.   PLoS Genetics

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1

(2008) Anna Selmecki et al.   MOLECULAR MICROBIOLOGY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE