RAD21 is a driver of chromosome 8 gain in Ewing sarcoma to mitigate replication stress

Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells

(2020) Marc El Beaino et al.   BMC CANCER

WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion

(2020) Bente Benedict et al.   DEVELOPMENTAL CELL

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

(2020) John Michael Replogle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

(2019) Gourish Mondal et al.   Nature Communications

Inhibition of the ATR–CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2

(2019) Stacia L. Koppenhafer et al.   MOLECULAR CANCER RESEARCH

MRX Increases Chromatin Accessibility at Stalled Replication Forks to Promote Nascent DNA Resection and Cohesin Loading

(2019) Axel Delamarre et al.   MOLECULAR CELL

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

(2018) Panagiotis Kotsantis et al.   Cancer Discovery

Ewing sarcoma

(2018) Thomas G. P. Grünewald et al.   Nature Reviews Disease Primers

Epigenome editing of microsatellite repeats defines tumor-specific enhancer functions and dependencies

(2018) Gaylor Boulay et al.   GENES & DEVELOPMENT

EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma

(2018) Aparna Gorthi et al.   NATURE

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

(2018) Nathaniel D. Anderson et al.   SCIENCE

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

(2016) Uri Ben-David et al.   Nature Communications

Efficacy of ATR inhibitors as single agents in Ewing sarcoma

(2016) Maria Nieto-Soler et al.   Oncotarget

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

(2015) Alyssa L. Kennedy et al.   Oncotarget

The Genomic Landscape of Pediatric Ewing Sarcoma

(2014) B. D. Crompton et al.   Cancer Discovery

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of STAG2 and TP53 Mutations

(2014) F. Tirode et al.   Cancer Discovery

The Genomic Landscape of the Ewing Sarcoma Family of Tumors Reveals Recurrent STAG2 Mutation

(2014) Andrew S. Brohl et al.   PLoS Genetics

OpenComet: An automated tool for comet assay image analysis

(2014) Benjamin M. Gyori et al.   Redox Biology

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

The many sides of CIN

(2013) Kristin A. Knouse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of a Heteromeric Complex That Promotes DNA Replication Origin Firing in Human Cells

(2013) D. Boos et al.   SCIENCE

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter

(2012) T. Abe et al.   DEVELOPMENT

Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

(2012) Silvia Remeseiro et al.   EMBO JOURNAL

Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl

(2012) N. Wu et al.   GENES & DEVELOPMENT

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

(2012) G. Ha et al.   GENOME RESEARCH

Cohesin Association to Replication Sites Depends on Rad50 and Promotes Fork Restart

(2012) Mireille Tittel-Elmer et al.   MOLECULAR CELL

Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks

(2012) Pierre Caron et al.   PLoS Genetics

The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation

(2010) Xiaodong Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chromatin Loading of E2F-MLL Complex by Cancer-Associated Coregulator ANCCA via Reading a Specific Histone Mark

(2010) A. S. Revenko et al.   MOLECULAR AND CELLULAR BIOLOGY

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Rad21-Cohesin Haploinsufficiency Impedes DNA Repair and Enhances Gastrointestinal Radiosensitivity in Mice

(2010) Huiling Xu et al.   PLoS One

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive Tumors

(2009) M. Ciro et al.   CANCER RESEARCH

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

EWS-FLI-1 Expression Triggers a Ewing's Sarcoma Initiation Program in Primary Human Mesenchymal Stem Cells

(2008) N. Riggi et al.   CANCER RESEARCH

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

The cohesin complex and its roles in chromosome biology

(2008) J.-M. Peters et al.   GENES & DEVELOPMENT