Causes and consequences of micronuclei

Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence

(2020) Xiaojuan Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT-III–mediated membrane fusion drives chromosome fragments through nuclear envelope channels

(2020) Brandt Warecki et al.   JOURNAL OF CELL BIOLOGY

Selective autophagy degrades nuclear pore complexes

(2020) Chia-Wei Lee et al.   NATURE CELL BIOLOGY

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

(2020) Saara Hämälistö et al.   Nature Communications

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

(2020) Steven Lohard et al.   Nature Communications

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Supernumerary B chromosomes of Aegilops speltoides undergo precise elimination in roots early in embryo development

(2020) Alevtina Ruban et al.   Nature Communications

Comprehensive Chromosome End Remodeling during Programmed DNA Elimination

(2020) Jianbin Wang et al.   CURRENT BIOLOGY

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation

(2020) Joanne Wei Kay Ku et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Basis of Tight Nuclear Tethering and Inactivation of cGAS

(2020) Baoyu Zhao et al.   NATURE

Structural basis for sequestration and autoinhibition of cGAS by chromatin

(2020) Sebastian Michalski et al.   NATURE

Structural mechanism of cGAS inhibition by the nucleosome

(2020) Ganesh R. Pathare et al.   NATURE

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

(2020) Baptiste Guey et al.   SCIENCE

Structural basis for the inhibition of cGAS by nucleosomes

(2020) Tomoya Kujirai et al.   SCIENCE

Structural basis of nucleosome-dependent cGAS inhibition

(2020) Joshua A. Boyer et al.   SCIENCE

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

(2019) Anne Margriet Heijink et al.   Nature Communications

PrimPol is required for the maintenance of efficient nuclear and mitochondrial DNA replication in human cells

(2019) Laura J Bailey et al.   NUCLEIC ACIDS RESEARCH

Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements

(2019) Peter Ly et al.   NATURE GENETICS

Female-biased embryonic death from inflammation induced by genomic instability

(2019) Adrian J. McNairn et al.   NATURE

Autophagic cell death restricts chromosomal instability during replicative crisis

(2019) Joe Nassour et al.   NATURE

MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis

(2019) Pia-Amata Leimbacher et al.   MOLECULAR CELL

Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase

(2019) Cindy L. Fonseca et al.   JOURNAL OF CELL BIOLOGY

Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne

(2019) Thomas Bonacci et al.   CELL CYCLE

Bloom syndrome protein restrains innate immune sensing of micronuclei by cGAS

(2019) Matthieu Gratia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

(2019) Sofie Traynor et al.   NUCLEIC ACIDS RESEARCH

The modular mechanism of chromocenter formation in Drosophila

(2019) Madhav Jagannathan et al.   eLife

ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage

(2019) Jessica Willan et al.   Oncogenesis

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

(2019) Christian Zierhut et al.   CELL

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

(2019) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability

(2019) David Pladevall-Morera et al.   NUCLEIC ACIDS RESEARCH

KHDC3L mutation causes recurrent pregnancy loss by inducing genomic instability of human early embryonic cells

(2019) Weidao Zhang et al.   PLOS BIOLOGY

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

(2019) Maja Kneissig et al.   eLife

SMC 5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability

(2019) Francesco Rossi et al.   EMBO REPORTS

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

(2019) Hannah E Volkman et al.   eLife

Nuclear envelope rupture: little holes, big openings

(2018) Emily M .Hatch   CURRENT OPINION IN CELL BIOLOGY

Chromosomes trapped in micronuclei are liable to segregation errors

(2018) Mar Soto et al.   JOURNAL OF CELL SCIENCE

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

The programmed DNA elimination and formation of micronuclei in germ line cells of the natural hybridogenetic water frog Pelophylax esculentus

(2018) Magdalena Chmielewska et al.   Scientific Reports

A conserved function for pericentromeric satellite DNA

(2018) Madhav Jagannathan et al.   eLife

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

(2018) Alessio De Magis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus

(2015) Keisuke Mochida et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

A chromosome separation checkpoint

(2014) Helder Maiato et al.   BIOESSAYS

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

Autophagic removal of micronuclei

(2012) Santiago Rello-Varona et al.   CELL CYCLE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS