Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability

Consequences of epigenetic derepression in facioscapulohumeral muscular dystrophy

(2020) Anna Greco et al.   CLINICAL GENETICS

Yeast Genome Maintenance by the Multifunctional PIF1 DNA Helicase Family

(2020) Julius Muellner et al.   Genes

CRISPR/Cas Derivatives as Novel Gene Modulating Tools: Possibilities and In Vivo Applications

(2020) Xingbo Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

(2019) Grégoire Cullot et al.   Nature Communications

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

(2019) Benjamin P. Kleinstiver et al.   NATURE BIOTECHNOLOGY

Transcription-mediated replication hindrance: a major driver of genome instability

(2019) Belén Gómez-González et al.   GENES & DEVELOPMENT

DNA Copy Number Variations as Markers of Mutagenic Impact

(2019) Galina Hovhannisyan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nuclease dead Cas9 is a programmable roadblock for DNA replication

(2019) Kelsey S. Whinn et al.   Scientific Reports

NanoPack: visualizing and processing long-read sequencing data

(2018) Wouter De Coster et al.   BIOINFORMATICS

Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

(2018) Michael Kosicki et al.   NATURE BIOTECHNOLOGY

Rad52-Rad51 association is essential to protect Rad51 filaments against Srs2, but facultative for filament formation

(2018) Emilie Ma et al.   eLife

Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3′-overhang

(2018) Su Bin Moon et al.   Nature Communications

R-loop formation by dCas9 is mutagenic in Saccharomyces cerevisiae

(2018) Marian F Laughery et al.   NUCLEIC ACIDS RESEARCH

Properties of Mitotic and Meiotic Recombination in the Tandemly-RepeatedCUP1Gene Cluster in the YeastSaccharomyces cerevisiae

(2017) Ying Zhao et al.   GENETICS

Ctf4 Prevents Genome Rearrangements by Suppressing DNA Double-Strand Break Formation and Its End Resection at Arrested Replication Forks

(2017) Mariko Sasaki et al.   MOLECULAR CELL

Mechanism of tandem duplication formation in BRCA1-mutant cells

(2017) Nicholas A. Willis et al.   NATURE

Environmental change drives accelerated adaptation through stimulated copy number variation

(2017) Ryan M. Hull et al.   PLOS BIOLOGY

Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication

(2017) Carl A Morrow et al.   eLife

Properties of Mitotic and Meiotic Recombination in the Tandemly-RepeatedCUP1Gene Cluster in the YeastSaccharomyces cerevisiae

(2017) Ying Zhao et al.   GENETICS

More than 10% of yeast genes are related to genome stability and influence cellular senescence via rDNA maintenance

(2016) Kimiko Saka et al.   NUCLEIC ACIDS RESEARCH

Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

(2016) Sarah R Hengel et al.   eLife

Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers

(2015) Gurushankar Chandramouly et al.   CHEMISTRY & BIOLOGY

The 100-genomes strains, anS. cerevisiaeresource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen

(2015) Pooja K. Strope et al.   GENOME RESEARCH

Extrachromosomal circular DNA is common in yeast

(2015) Henrik D. Møller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

(2014) Yuki Naito et al.   BIOINFORMATICS

The Escherichia coli Tus–Ter replication fork barrier causes site-specific DNA replication perturbation in yeast

(2014) Nicolai B. Larsen et al.   Nature Communications

Structures of Naturally Evolved CUP1 Tandem Arrays in Yeast Indicate That These Arrays Are Generated by Unequal Nonhomologous Recombination

(2014) Ying Zhao et al.   G3-Genes Genomes Genetics

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

(2013) Baohui Chen et al.   CELL

CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes

(2013) Luke A. Gilbert et al.   CELL

Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein

(2013) W. Kagawa et al.   NUCLEIC ACIDS RESEARCH

Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

(2013) James E. DiCarlo et al.   NUCLEIC ACIDS RESEARCH

Competition, collaboration and coordination - determining how cells bypass DNA damage

(2012) J. E. Sale   JOURNAL OF CELL SCIENCE

Amplification of the CUP1 gene is associated with evolution of copper tolerance in Saccharomyces cerevisiae

(2012) G. M. Adamo et al.   MICROBIOLOGY-SGM

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

(2011) Takehiko Kobayashi   CELLULAR AND MOLECULAR LIFE SCIENCES

Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae

(2011) R. Scott McIsaac et al.   MOLECULAR BIOLOGY OF THE CELL

Repetitive DNA and next-generation sequencing: computational challenges and solutions

(2011) Todd J. Treangen et al.   NATURE REVIEWS GENETICS

Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery

(2011) Jonathan Houseley et al.   NUCLEIC ACIDS RESEARCH

OriDB, the DNA replication origin database updated and extended

(2011) C. C. Siow et al.   NUCLEIC ACIDS RESEARCH

An improved method for whole protein extraction from yeast Saccharomyces cerevisiae

(2011) Tingting Zhang et al.   YEAST

Origin-Dependent Inverted-Repeat Amplification: A Replication-Based Model for Generating Palindromic Amplicons

(2011) Bonita J. Brewer et al.   PLoS Genetics

Loss of DNA Replication Control Is a Potent Inducer of Gene Amplification

(2010) B. M. Green et al.   SCIENCE

Role of the Rad52 Amino-terminal DNA Binding Activity in DNA Strand Capture in Homologous Recombination

(2009) Idina Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Histone Code for Chromatin Assembly

(2008) Jeffrey Fillingham et al.   CELL

Interaction with RPA Is Necessary for Rad52 Repair Center Formation and for Its Mediator Activity

(2008) Iben Plate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY